Navigation Links
Pioneering research succeeds in producing industrially vital chemical through engineered bacteria
Date:8/26/2009

e putrescine exporter, which allows excretion of intracellularly made putrescine, was engineered while a global regulator was engineered to further increase the concentration of putrescine. The final result of this process was an engineered E. coli strain which produced 24.2 g of putrescine per litre.

However, as it was believed that putrescine is toxic to microorganisms the team had to study putrescine tolerance in E. coli before it could be engineered to overproduce the chemical to the levels needed for industrial production.

The results revealed that E. coli can tolerate at least 0.5 M of putrescine, which is tenfold higher than the usual concentration in the cell. This level of tolerance was an important surprise as it means that E. coli can be engineered to overproduce putrescine to industrially competitive levels.

"The previously expected toxicity of putrescine may explain why its microbial production has been overlooked," said Lee. "Now a metabolically engineered E.coli strain has been developed which is capable of efficiently producing putrescine using renewable methods to an industrial level. This metabolic engineering framework should be useful for developing metabolically engineered microorganisms for the efficient production of other chemicals from renewable resources."


'/>"/>

Contact: Ben Norman
Benorman@wiley.com
44-012-437-70375
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Georgia Reproductive Specialists is First in Southeast to Offer Pioneering Test of Womens Biological Clock
2. NorthPoint Domain and Boston Medical Center Partner to Apply Advanced Patient Engagement Instruments to Pioneering Cardiac Robotic Surgery Program
3. Pioneering IVF Technique Produces Region's First Pregnancy
4. PAREXEL Expands Pioneering Asian Ethnobridging Expertise
5. Pioneering Cancer Center Introduces Advanced Varian RapidArc(TM) Treatments for Cancer Patients in Central Germany
6. Frost & Sullivan Recognizes Nanopoint for its Pioneering Cell Imaging Solution, the cellTRAY(R) Imaging System CT-2000
7. DNA Software, Inc. Awarded $2.5 M in NIH Funding to Develop Pioneering Nucleic Acid-based Technologies
8. Research Triangle Area Health Care Collaborative Launches Bridges to Excellence(R) Initiative to Improve Quality and Lower Costs
9. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
10. BioMarin Licenses Technology From Leading Cystic Fibrosis Research Laboratory at the University of California, San Francisco
11. IDM Pharma Names Dr. Jeffrey W. Sherman Chief Medical Officer and Senior Vice President of Research and Development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2015)... ... July 29, 2015 , ... Available in select spas and ... a nighttime-specific product that targets fat cells for extreme contouring action. During sleep ... fat cells, inhibiting the formation of new fat. Upon waking CHRONODIET breaks down ...
(Date:7/29/2015)... MA (PRWEB) , ... July 29, 2015 , ... Nearly ... of serious diseases. Yet few people realize that a rich source of these cells ... young adults, and teeth that need to be pulled to make room for braces. ...
(Date:7/28/2015)... INCLINE VILLAGE, Nev. , July 28, 2015 /PRNewswire/ ... PDLI ) today announced that the Company will release ... ended June 30, 2015, on Wednesday, August 5, 2015, ... call and webcast that day at 4:30 p.m. Eastern ... relating to the call will be available via the ...
(Date:7/28/2015)... 21, 2015 Research ... addition of the "Analysis of the Global ... offering. Globally, flow cytometry remains a ... proliferation, cancer, and stem cells. But the market ... because of demand from underdeveloped nations to quantitate ...
Breaking Biology Technology:Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 2Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 3Advanced Oral and Maxillofacial Surgery (AOMS) in Elmhurst, IL Partners with Provia Labs to make Store-A-Toothâ„¢ Dental Stem Cell Banking Available to their Patients 2PDL BioPharma to Announce Second Quarter 2015 Financial Results on August 5, 2015 2Analysis of the Global Flow Cytometry Market 2012-2018 with a 2014 Base Year and a 2015-2018 Forecast Period 2
... Inc., a,developer and manufacturer of specialized short-wavelength light ... that enables light sources to achieve extreme high ... The LDLS(TM) Laser-Driven,Light Source is embodied in the ... compact light products that can be used in ...
... Inc. (Nasdaq:,CEPH) announced today that the U.S. ... formulation patent for AMRIX(R) (Cyclobenzaprine,Hydrochloride Extended-Release Capsules). ... Inc., the developer of AMRIX, and expires ... an exclusive license from Eurand to,market AMRIX ...
... PAREXEL International,Corporation (Nasdaq: PRXL ), a ... it is expanding its clinical pharmacology,capabilities in ... PAREXEL,is enhancing existing services in early phase ... combining traditional pharmacodynamic,methods with relevant biomarkers, which ...
Cached Biology Technology:Energetiq's Laser-Driven Light Source Technology Enables Continuous Spectrum Light Sources, from Visible to Deep Ultraviolet 2Cephalon Announces Issuance of Patent for AMRIX 2Cephalon Announces Issuance of Patent for AMRIX 3PAREXEL Enhances Early Phase Clinical Development Offering for Central Nervous System Studies 2PAREXEL Enhances Early Phase Clinical Development Offering for Central Nervous System Studies 3PAREXEL Enhances Early Phase Clinical Development Offering for Central Nervous System Studies 4
(Date:7/21/2015)... July 21, 2015  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce ... announces that it has filed provisional patent 62/192218 ... This invention highlights next generation ... an account, but also the user using unique ...
(Date:7/13/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ... today announced sampling of ClearPad ® 4300, ... (TDDI) product targeting smartphones and tablets. This new ... , best-in-class touch controller IP and systems ... in the company,s Japan Design Center. TDDI enables ...
(Date:7/9/2015)... Research and Markets( ... "Biometrics for Banking; Market & Technology Analysis, ... their offering. The adoption for banking ... and the forecast is that by 2020 it ... involved in delivering biometric systems to the banking ...
Breaking Biology News(10 mins):NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3
... research at York has revealed so-called Jekyll and Hyde ... without using insecticides. Researchers at the University of ... bacteria that live in them and discovered an ... insects. In fact, many insects thrive on plant food ...
... poll to reflect the discovery reported internationally in November ... stem cells or their near equivalents. When asked about ... 10, or 63 percent, say that both embryonic and ... say this development means embryonic stem cell research is ...
... RFID FOR STOCK ... AND STORE FRONT SOLUTION, SAN JOSE, Calif., Dec. 18 ... provider announced today the launch of a new product tailor-made,for the ... purpose is to provide the retail industry a total solution for,efficient ...
Cached Biology News:Widespread support for nonembryonic stem cell research, VCU Life Sciences Survey shows 2Titanium Group Announces Launch of New Identification Solution Targeting High Growth Retail Sector 2Titanium Group Announces Launch of New Identification Solution Targeting High Growth Retail Sector 3
A robust formulation of Taq Polymerase supplied with a 10X colored reaction buffer which allows Direct Gel-Loading...
...
Borrelia Burgdorfen (IgG) -Ab EIA Sample Size: 100 l...
... inhibitor that noncovalently binds and inactivates neutral pancreatic ... RNase 1, T1, T2, H, U1, U2 or ... inhibitor in that it has a more robust ... RNase in the absence of DTT or other ...
Biology Products: