Navigation Links
Pinpoint precision: Delivering a biochemical payload to 1 cell
Date:7/7/2010

rk with Dr. Levchenko's group demonstrates just how extremely versatile a technique it is."

To test the system, the team cultured cervical cancer cells in a dish. Then, using electrical fields perpendicular to one another, they were able to zap the nanowires into a pre-set spot and plop them down in a precise location. "In this way, we can predetermine the path that the wires will travel and deliver a molecular payload to a single cell among many, and even to a specific part of the cell," Levchenko said.

During the course of this study, the team also established that the desired effect generated by the nanowire-delivered TNF-alpha was similar to that experienced by a cell in a living organism.

The team members envision many possibilities for this method of subcellular molecule delivery.

"For example, there are many other ways to trigger the release of the molecule from the wires: photo release, chemical release, temperature release. Furthermore, one could attach many molecules to the nanowires at the same time," Levchenko said. He added that the nanowires can be made much smaller, but said that for this study the wires were made large enough to see with optical microscopy.

Ultimately, Levchenko sees the nanowires becoming a useful tool for basic research.

"With these wires, we are trying to mimic the way that cells talk to each other," he said. "They could be a wonderful tool that could be used in fundamental or applied research." Drug delivery applications could be much further off. However,

Levchenko said, "If the wires retain their negative charge, electrical fields could be used to manipulate and maneuver their position in the living tissue."


'/>"/>

Contact: Mary Spiro
mspiro@jhu.edu
410-516-4802
Johns Hopkins University
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Low-cost DNA test to pinpoint risk of inherited diseases
2. PARI Respiratory to Present New Study Comparing Nebulizers Delivering Budesonide at CHEST 2008
3. OmniComm Systems, Inc. Is Fueled by Another Strong Quarter Delivering Electronic Data Capture (EDC) Solutions & Services
4. Dow AgroSciences Delivering Beyond Expectations
5. Inventigo and GridGain Systems Team Up on Delivering Cloud-Enabled High Performance XML Processing
6. Alberta companies delivering new products to the health & medical marketplace
7. Alberta companies delivering new products to the Conventional Energy marketplace
8. Syngenta and Metabolon Inc. in Collaborative Research Agreement for Biochemical Profiling Technology
9. Enerkem announces first commercial-scale biofuels and biochemicals plant is entering start-up phase
10. Blue Marble Energy and Bionavitas Announce Partnership to Produce Industrial Biochemicals from Microalgae
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSX.V: RP), a ... of autologous cell therapies, announced today the publication of ... conjunction with co-authors from Kyoto University and the University ... clinical research using dermal sheath cup (DSC) cells to ... paper entitled " Hair Follicle Dermal Stem Cells Regenerate ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 ... peer-reviewed publication of original research, reviews and editorials ... and clinical practice, today published a provocative article ... the development, progression and potential treatment of prostate ... endocrinology research and proposes the possibility that there ...
(Date:12/19/2014)... Charm Sciences is pleased to announce ... of Aflatoxin M1 in raw commingled milk is the ... validation. The peer reviewed report of the validation by ... Agricultural and Fisheries Research (ILVO-T&V) has been published by ... the most toxic aflatoxin and a known carcinogen, can ...
(Date:12/19/2014)... -- Bina Technologies, Inc. (Bina, Redwood City, ... been acquired by Roche (SIX: RO, ROG; OTCQX: RHHBY).  ... that provides a big data platform for centralized management ... the academic and translational research markets.  Bina will be ... to focus on development of their innovative genomic analysis ...
Breaking Biology Technology:Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... announces that a new market research report is ... Markets for Enzymes in Industrial Applications ... STUDY OBJECTIVES BCC,s ... an overview of the current and future characteristics ...
... a new Contract Research Organization (CRO), Agility Clinical, Inc., ... clinical research and consulting services to small and virtual ... Company was formed by David F. Hale, Chairman and ... to Hale, "Agility,s mission is to provide services to ...
... 2012  Auxilium Pharmaceuticals, Inc. (Nasdaq: AUXL ) today ... Global Healthcare Conference to be held June 4-7, 2012 at ... Chief Executive Officer and President, is scheduled to present an ... a.m. ET on Monday, June 4, 2012. A breakout session ...
Cached Biology Technology:Global Markets for Enzymes in Industrial Applications 2Global Markets for Enzymes in Industrial Applications 3Global Markets for Enzymes in Industrial Applications 4Global Markets for Enzymes in Industrial Applications 5Global Markets for Enzymes in Industrial Applications 6Global Markets for Enzymes in Industrial Applications 7Global Markets for Enzymes in Industrial Applications 8Global Markets for Enzymes in Industrial Applications 9Global Markets for Enzymes in Industrial Applications 10Global Markets for Enzymes in Industrial Applications 11Global Markets for Enzymes in Industrial Applications 12Global Markets for Enzymes in Industrial Applications 13Global Markets for Enzymes in Industrial Applications 14Global Markets for Enzymes in Industrial Applications 15Global Markets for Enzymes in Industrial Applications 16Global Markets for Enzymes in Industrial Applications 17Global Markets for Enzymes in Industrial Applications 18Global Markets for Enzymes in Industrial Applications 19Agility Clinical, Inc., a Specialty Contract Research Organization is Formed 2Auxilium Pharmaceuticals, Inc. to Present at the Jefferies 2012 Global Healthcare Conference 2Auxilium Pharmaceuticals, Inc. to Present at the Jefferies 2012 Global Healthcare Conference 3Auxilium Pharmaceuticals, Inc. to Present at the Jefferies 2012 Global Healthcare Conference 4
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research ... announced the addition of the "Global Facial ... http://photos.prnewswire.com/prnh/20130307/600769 ... the identification of individuals. Facial recognition system measures ... as nose, jaw edges, mouth, and the distance ...
(Date:12/11/2014)... PAUL, Minn. , Dec. 10, 2014 /PRNewswire/ ... wireless physiologic monitoring, has released a new series ... needs of preclinical toxicology researchers. M series, part ... help toxicologists collect the best possible physiologic data ... Adding functional endpoints to toxicology studies ...
(Date:12/10/2014)... Dec. 9, 2014 CIE San Diego has ... provides the connective tissue that enhances care coordination among ... easily share client-level information; earned a second $1 million ... organizations serving seniors aging in community and; will be ... December 11 th 4-6p. CIE San ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... Iowa - Some fisheries in the United States are ... to protect fish stocks, and Iowa State University researchers ... economic boon to the fishing industry., Quinn Weninger and ... costs under the old system and compared that to ...
... to the discovery of how to regenerate tissue damaged by ... PDGF as a key factor in the proliferation and transformation ... muscle and contributes to vessels. The study was published ... Proceedings of the National Academy of Sciences of ...
... computer gadgetry to monitor the ever-evolving landscape of our planet ... of a new knowledge exchange network being led by The ... by Dr Paul Aplin in the University,s School of Geography, ... Environment Research Council (NERC). It will focus on technology ...
Cached Biology News:New fisheries system will save about $20 million, Iowa State University researchers find 2New fisheries system will save about $20 million, Iowa State University researchers find 3Childrens Hospital LA discovers growth factor essential to epicardial cell function 2Keeping a watch on the world 2Keeping a watch on the world 3
LIVE/DEAD® Cell-Mediated Cytotoxicity Kit *for animal cells* *2000 assays*...
... The SlowFade Light Antifade Kit is an ... seen with fluorescent dyes. This formulation of ... AMCA and Cascade Blue fluorophores that is ... This kit is available with the blue-fluorescent ...
Human Xg Affinity Purified Polyclonal Ab Keywords: Xg glycoprotein, hereditary hemorrhagic telangiectasia Protein Family: ...
in vitro Translation, Accessory Products...
Biology Products: