Navigation Links
Pinpoint precision: Delivering a biochemical payload to 1 cell
Date:7/7/2010

which are metallic cylinders a few hundred nanometers or smaller in diameter. Just as the unsuspecting sports spectator would feel only a light touch from a toothpick being dropped on the head, the cell reacts only to the molecules released from the nanowire in one very precise place where the wire touches the cell's surface.

With contributions from Chia-Ling Chien, a professor of physics and astronomy in the Krieger School of Arts and Sciences, and Robert Cammarata, a professor of materials science and engineering in the Whiting School, the team developed nanowires coated with a molecule called tumor necrosis factor-alpha (TNF-alpha), a substance released by pathogen-gobbling macrophages, commonly called white blood cells. Under certain cellular conditions, the presence of TNF-alpha triggers cells to switch on genes that help fight infection, but TNF-alpha also is capable of blocking tumor growth and halting viral replication.

Exposure to too much TNF-alpha, however, causes an organism to go into a potentially lethal state called septic shock, Levchenko said.

Fortunately, TNF-alpha stays put once it is released from the wire to the cell surface, and because the effect of TNF-alpha is localized, the tiny bit delivered by the wire is enough to trigger the desired cellular response. Much the same thing happens when TNF-alpha is excreted by a white blood cell.

Additionally, the coating of TNF-alpha gives the nanowire a negative charge, making the wire easier to maneuver via the two perpendicular electrical fields of the "tweezer" device, a technique developed by Donglei Fan as part of her Johns Hopkins doctoral research in materials science and engineering.

"The electric tweezers were initially developed to assemble, transport and rotate nanowires in solution," Cammarata said. "Donglei then showed how to use the tweezers to produce patterned nanowire arrays as well as construct nanomotors and nano-oscillators. This new wo
'/>"/>

Contact: Mary Spiro
mspiro@jhu.edu
410-516-4802
Johns Hopkins University
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Low-cost DNA test to pinpoint risk of inherited diseases
2. PARI Respiratory to Present New Study Comparing Nebulizers Delivering Budesonide at CHEST 2008
3. OmniComm Systems, Inc. Is Fueled by Another Strong Quarter Delivering Electronic Data Capture (EDC) Solutions & Services
4. Dow AgroSciences Delivering Beyond Expectations
5. Inventigo and GridGain Systems Team Up on Delivering Cloud-Enabled High Performance XML Processing
6. Alberta companies delivering new products to the health & medical marketplace
7. Alberta companies delivering new products to the Conventional Energy marketplace
8. Syngenta and Metabolon Inc. in Collaborative Research Agreement for Biochemical Profiling Technology
9. Enerkem announces first commercial-scale biofuels and biochemicals plant is entering start-up phase
10. Blue Marble Energy and Bionavitas Announce Partnership to Produce Industrial Biochemicals from Microalgae
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... (PRWEB) January 15, 2014 The Pittcon Organizing ... of Food Safety Tech , an e-Journal and producer ... an agreement for the second year for the co-location of ... 2014. The partnership provides that the registration fee to attend ...
(Date:1/15/2014)... SAN JOSE, California , January 15, 2014 ... for cancer, today announced the appointment of Thomas C Reynolds ... over 20 years, development experience gained in the biotechnology industry, ... "I am delighted to welcome Tom at this transformative ...
(Date:1/15/2014)... More than 5 million Americans are ... 3 seniors will die with Alzheimer’s or another dementia, ... have shocked many Americans into looking for ways to ... tragic age-related cognitive disorders. Jonathan Weisman, president of Biohack ...
(Date:1/15/2014)... 2013 was a banner year of continued ... saw continued independent research led by the team at ... $1 million grant from the Susanne Marcus Collins Foundation, ... peer reviewed journal, Amy Grant highlighted Brainwave Optimization® in ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... Tornado-Torn ... Health Care Facility, MALVERN, Pa., Jan. ... a devastating 2007 tornado,Siemens has announced that, as part of its ... new MAGNETOM ESSENZA, worth,approximately $800,000., Siemens took notice of Sumter,s ...
... talent and investors to state, TOPEKA, Kan., ... announced today a "Come Home to Kansas" initiative ... investors to Kansas. Partners in this project include ... the Kansas,Bioscience Organization and the KTEC PIPELINE., ...
... Inc.,(Nasdaq: CRDC ) today reported financial results ... and six months ended December 31, 2007., ... over 1,000,C-Port systems shipped in the past quarter ... to enable minimally-invasive cardiac surgery and,substantial advancement for ...
Cached Biology Technology:A Magnetic Gift: Sumter Regional Hospital Receives New MRI as Charitable Donation From Siemens 2'Come Home to Kansas' Announced by KTEC 2Cardica Announces Fiscal 2008 Second Quarter Financial Results and Business Progress 2Cardica Announces Fiscal 2008 Second Quarter Financial Results and Business Progress 3Cardica Announces Fiscal 2008 Second Quarter Financial Results and Business Progress 4Cardica Announces Fiscal 2008 Second Quarter Financial Results and Business Progress 5Cardica Announces Fiscal 2008 Second Quarter Financial Results and Business Progress 6Cardica Announces Fiscal 2008 Second Quarter Financial Results and Business Progress 7
(Date:4/18/2014)... emergency contraceptive pills in Peru found that 28 ... substandard quality or falsified. Many pills released the ... active ingredient. One batch had no active ingredient ... drugs, researchers at the Georgia Institute of Technology ... quickly assess suspected counterfeit drugs and then characterize ...
(Date:4/18/2014)... Ancient DNA adds a twist to the story of how ... published April 21 in the journal Proceedings of the ... bones of chickens that lived 200-2300 years ago in Europe, ... chickens may have looked far different from the chickens we ... traits we associate with modern domestic chickens -- such as ...
(Date:4/17/2014)... 17 In the most densely forested and most ... two centuries of human needs, values and practices. Disturbances ... forests for agriculture and development, have set the stage ... Forest Service study reports. , The report Five ... management needs in the Northern United States ...
Breaking Biology News(10 mins):Counterfeit contraceptives found in South America 2Counterfeit contraceptives found in South America 3Ancient DNA offers clues to how barnyard chickens came to be 2Five anthropogenic factors that will radically alter northern forests in 50 years 2Five anthropogenic factors that will radically alter northern forests in 50 years 3
... MANHATTAN, Kan. -- If cats really had nine lives, one ... of diseases that threaten feline health. Yunjeong Kim, a ... Kansas State University, has developed a research approach that tackles ... work is being supported by a $156,342 award from the ...
... ensure that the benefits of genetic resources are shared in ... the Convention on Biological Diversity, though questions remain about how ... new report from the Synthetic Biology Project at the Woodrow ... may affect U.S. researchers working in the field of synthetic ...
... (4 November 2013) The Population Council, an international ... development issues, will present findings from more than 40 ... Addis Ababa, Ethiopia (November 12-15, 2013). Notable ... in programs that strengthen gender equity; improve financing mechanisms ...
Cached Biology News:College of Veterinary Medicine researcher doubles down on deadly, infectious cat diseases 2College of Veterinary Medicine researcher doubles down on deadly, infectious cat diseases 3Population Council to present more than 40 studies at International Conference on Family Planning 2Population Council to present more than 40 studies at International Conference on Family Planning 3Population Council to present more than 40 studies at International Conference on Family Planning 4
MOUSE ANTI RAT RT1Bu Immunogen: Rat thymocyte membrane glycoproteins...
RABBIT ANTI HUMAN CYTOCHROME P450 1A1/2 Immunogen: Purified human CYP1A2 expressed in E.Coli ...
RABBIT ANTI HUMAN APP (KP1 DOMAIN) Immunogen: Synthetic peptide composed of amino acids 292-312 from the KPI domain of human APP....
... The Light Diagnostics Cytomegalovirus (CMV) pp65 Antigenemia ... qualitative identification of lower matrix protein pp65 ... Kit Components: ... One bottle containing 220 mL of buffered ...
Biology Products: