Navigation Links
Pigs bred with cystic fibrosis provide model to mimic human disease
Date:9/25/2008

COLUMBIA, Mo. Cystic Fibrosis (CF) continues to be a lethal disease for humans despite the identification of the problematic gene two decades ago. Many humans born with CF the most common genetic disease in Caucasians - often die because of a lung disease developed later. Scientists have been unable to develop an animal model that develops the fatal lung disease. Now, a University of Missouri researcher is producing pigs born with cystic fibrosis that mimic the exact symptoms of a newborn with CF. The researchers are hopeful that these pigs will continue to mimic the human symptoms so the fatal lung disease can be studied and ultimately treated. The research appears in the journal Science.

"Right now, if you want to do experiments to find treatments or therapies for the lung disease that is fatal for people with CF, you would have to experiment on kids that have CF," said Randy Prather, distinguished professor of reproductive biotechnology in the MU College of Agriculture, Food and Natural Resources. "When the genetic mutation is introduced into mice, they do not display the symptoms of CF. That's why these new swine models are so important. We have been able to get them through the initial stages of the disease, which they display just like humans, and now we are just waiting for them to grow and potentially develop the lung disease so we can start experimenting in ways that have never been possible."

Prather collaborated with Michael Welsh from the Howard Hughes Medical Institute at the University of Iowa. To create the genetic defect in pigs, a team led by Welsh made genetic modifications in pig cells. Prather's group then generated the genetically modified pigs from the cells using a process known as nuclear transfer. The pigs called founder animals - that were produced carried only one copy of the mutated gene. Prather bred the pigs naturally and now many piglets have been born with CF.

Once a lit
'/>"/>

Contact: Jennifer Faddis
Faddisj@missouri.edu
573-882-6217
University of Missouri-Columbia
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. 40 High-Achieving Students with Cystic Fibrosis Receive $100,000 Total in Higher Education Scholarships From SolvayCARES(SM)
2. PTC124 Shows Promising Activity in Cystic Fibrosis; Phase 2 Proof-of-Concept Data Published in the Lancet
3. Cystic Fibrosis - Axentis Pharma Takes Over Patents and Continues Development of Innovative Platform Technology
4. Cystic Fibrosis Trial In Children Returns Positive Data
5. Study Confirms Anti-Infective ARIKACE(TM) Effectively Penetrates Mucus and Biofilm, and Kills Pseudomonas, a Bacteria Plaguing Cystic Fibrosis Patients
6. Genetic manipulation might model cystic fibrosis
7. Mpex Candidate, MP-376, Granted U.S. Orphan Drug Status for the Treatment of Cystic Fibrosis
8. Data show a decline in cystic fibrosis since introduction of prenatal carrier screening
9. Cystic Fibrosis: License Agreement Boosts Development of Therapy Against Lung Infections
10. PTC Therapeutics Announces Encouraging Additional Phase 2 Results of PTC124 in Cystic Fibrosis
11. GeneGo and the Cystic Fibrosis Foundation Collaborate to Advance Understanding of Cystic Fibrosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pigs bred with cystic fibrosis provide model to mimic human disease
(Date:3/25/2015)... market is one of the most attractive in the ... plus a growing economy and increasing government investment in ... The Russian market is set to grow at twice ... estimates around 10-15% annually reaching an approximate market value ... Cross Green Cross provides total healthcare solutions ...
(Date:3/25/2015)... (PRWEB) March 25, 2015 The ... of smartphones have fuelled social media growth, with ... currently engaged in social networking. Insurance companies are ... communicate with clients and promote a diversity of ... over are increasingly exploiting social networking services as ...
(Date:3/25/2015)... and REYKJAVIK, Iceland , March 25, 2015 ... the genome to create better medicine, today congratulated the scientists ... of whole-genome data yet undertaken. The studies ... – are built around the most comprehensive population-wide tally ... deCODE scientists led by Kari Stefansson , deCODE,s founder ...
(Date:3/25/2015)... 2015 Having added two International locations ... of 2014, ITRA Global proudly announced recently the organization’s ... Representative Alliance, based in the United States, is one ... occupiers of commercial real estate. , Saltwood International ... Poland that exclusively advises occupiers of office space, ensuring ...
Breaking Biology Technology:Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3Landmark deCODE Studies Demonstrate the Power of Truly Big Genomics for Improving Medicine Worldwide 2International Organization Expands its Global Reach to Warsaw, Poland 2
... a,biotechnology company translating the complexity of human biology to,develop ... manager of its Scientific Programs, was selected by Mass ... "We are proud to have a young, successful individual ... O. Elliston, president and CEO at,Genstruct. "She has been ...
... of Venous Thromboembolism -, LEXINGTON, Mass., Oct. ... US Food and Drug Administration (FDA) has,granted 510(k) ... D-Dimer HS,to exclude venous thromboembolism (VTE) in outpatients ... (PE), when used in conjunction,with a clinical pretest ...
... Oct. 9 A homegrown New Jersey company ... pedigree of pharmaceuticals everywhere. Secure Symbology, (http://www.securesymbology.com ), ... as an,Honored Finalist as Emerging Business of the ... for its vision to wipe out counterfeit drugs,worldwide. ...
Cached Biology Technology:Genstruct's Andrea Matthews Selected for Mass High Tech's 'People to Watch Under 30' 2Instrumentation Laboratory Receives FDA Clearance to Expand the Intended Use for HemosIL(R) D-Dimer HS Assay 2Secure Symbology: Making New Jersey Proud While Saving Lives 2
(Date:3/17/2015)... , March 17, 2015 MedNet ... specializing in clinical study management systems, is pleased ... attendance at ARENA,s Outsourcing in Clinical Trials Southeast ... event provides an excellent forum for MedNet to ... and affordable software-as-a-service (SaaS) eClinical technology platform. ...
(Date:3/16/2015)... Between 16 and 20 ... innovations in biometric identification at the CeBIT exhibition ...      (Photo: http://photos.prnewswire.com/prnh/20150316/735333 ) , ... at the forefront: the company,s all new BiometricGate ... Germany . BiometricGate is the first ...
(Date:3/12/2015)... , March 12, 2015 ... a standardized identity and access management (IAM) solution ... implementation schedule. With Beta System,s new IAM package, ... best practices gleaned from multiple IAM implementations across ... the software as well as any necessary services ...
Breaking Biology News(10 mins):Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2
... Virginia Key, Fla. -- Ronald Hoenig and Aaron ... Miami (UM) Rosenstiel School of Marine UM Rosenstiel ... 6th Rothschild Entrepreneurship Competitionand Atmospheric Science, won first ... years 6th Annual Leigh Rothschild Entrepreneurship Competition. ...
... at San Antonio will bring together energy leaders, industry ... hosts the inaugural UTSA North American Energy Summit (NAES) ... UTSA Downtown Campus. The summit will feature experts with ... addressing the energy needs for future generations. ...
... the latest American Chemical Society (ACS) News Service Weekly PressPac ... Engineering News.,Please credit the individual journal or the American Chemical ... IS FOR IMMEDIATE USE EXCEPT ARTICLE #5, which is embargoed ... ARTICLE #1 FOR IMMEDIATE RELEASE Study calls for ...
Cached Biology News:Aquaculture concept leaves judges 'goggle eyed' 2UTSA hosts North American Energy Summit May 1-2 2American Chemical Society's Weekly PressPac -- April 23, 2008 2American Chemical Society's Weekly PressPac -- April 23, 2008 3American Chemical Society's Weekly PressPac -- April 23, 2008 4American Chemical Society's Weekly PressPac -- April 23, 2008 5American Chemical Society's Weekly PressPac -- April 23, 2008 6American Chemical Society's Weekly PressPac -- April 23, 2008 7American Chemical Society's Weekly PressPac -- April 23, 2008 8
... FXP is the latest entry in the Biomek ... accuracy and increased robustness, it can meet the ... be configured with either one or two pipetting ... FXP sets the standard for flexible laboratory solutions ...
... FX P is the latest entry in ... greater positional accuracy and increased robustness, it can ... It can be configured with either one or ... the Biomek FX P sets the standard ...
... Simplify the process and you reduce ... built into the CEQ 8000. Developed using ... and leadership in capillary electrophoresis technology, the ... analysis system. This system automatically fills the ...
... a simple high performance method for removing ... without significant dilution of protein solution. ... Detergent-OUT Spin column and collect detergent free ... suitable for removing detergents from a 1.0 ...
Biology Products: