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Physical properties predict stem cell outcome
Date:5/21/2012

rmine whether filtering a sample by different mechanical characteristics could result in extracting a higher concentration of useful cells from tissue. They found that while yields using current methods of looking for molecular biomarkers are less than 1 percent, yields based on mechanical properties could increase to 3 percent for bone-making cells, 6 percent for cartilage, and 9 percent for fat.

Encouraged by the results, which he acknowledges are basic, Darling's group is already working toward a more practical realization of the discovery. After all, surgeons aren't going to bring atomic force microscopes into the operating room; those devices work too slowly to identify enough cells in a reasonable time.

"To actually apply this, we need some sort of high-throughput mechanical testing device," he said. "That is where the next stage is. That's something that my lab is working on right now."

So the idea is taking shape, like a stem cell striving to become fat, bone, or cartilage.


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Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

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