Navigation Links
Phosphagenics Announces Successful Phase 1 Transdermal Oxycodone Clinical Trial Results
Date:12/17/2007

MELBOURNE, Australia, Dec. 17 /PRNewswire-FirstCall/ -- Phosphagenics Limited ("Phosphagenics") (ASX: POH, AIM: PSG, OTCQX: PPGNY) today announced positive results of its Phase 1 clinical trial that showed its delivery technology, TPM, delivered leading pain-relief drug oxycodone through the skin without causing disruption or irritation of any kind.

These results support Phosphagenics' aims to be the first company to commercialize a sustained release oxycodone patch for the management of chronic pain.

"Oxycodone, with worldwide annual sales of more than $1 billion, is more potent than morphine with fewer adverse effects; however, oxycodone is not available transdermally due to serious issues relating to skin sensitization and irritation," said Dr. Esra Ogru, Executive Vice President of Research and Development at Phosphagenics. "Our trial results show that TPM can deliver oxycodone through the skin in a sustained release formulation without causing skin irritation."

This trial, which was conducted by CMAX (an independent clinical research organization located at the Royal Adelaide Hospital) was a single-centre, single-blinded, pharmacokinetic trial in 16 healthy subjects. The trial endpoints were to evaluate the safety and tolerability of the TPM/Oxycodone formulation and the ability of the TPM technology to deliver oxycodone into the body.

The oxycodone, administered as a single transdermal application, was safe with no adverse events reported. Oxycodone was detected in the subjects for at least 48 hours. The results demonstrate that the formulation is bioavailable and effective in delivering oxycodone into the body.

A collaborative program is now under way with a world leading patch development company to incorporate the current formulation into a patch system. Plans are also underway to undertake a pivotal clinical study in the first half of 2008.

"Developing our pain relief pipeline builds on the success of Phosph
'/>"/>

SOURCE Phosphagenics Limited
Copyright©2007 PR Newswire.
All rights reserved

1

GOOD

Page: 1 2 3

Related biology technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. YM BIOSCIENCES ANNOUNCES COMPLIANCE WITH AIM RULE 26
3. Emisphere Technologies, Inc. Announces Pricing of Registered Direct Offering
4. BioLife Solutions Announces Exclusive CryoStor(TM) Supply Agreement With the New England Cryogenic Center, Inc.
5. Carrington Announces Nasdaq Communication; Prepares for Shares to Be Quoted on the OTC Bulletin Board and Pink Sheets
6. China Kangtai Cactus Biotech Files 2nd Quarter 2007 10QSB and Announces Unaudited Quarterly Results
7. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
8. Advanced Life Sciences Announces Receipt of Nasdaq Staff Letter
9. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
10. Angiotech announces additional diameters of sutures to further expand its Quill(TM) SRS PDO product line
11. CNS Response Announces Fiscal Third Quarter 2007 Results

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2009)...e able to find explosive materials and persons who...hes, the National Institute of Standards and Techn...Homeland Security, has developed a new certified r...M) 2905, Trace Particulate Explosives. Compatible ...ill be helpful in calibrating, testing and develop...
(Date:11/18/2009)... Belfast are developing new sensors to detect chem...he fight against the threat of terrorist attacks. ...e, an individual or crime scene to gather a sample...hat can detect the presence of chemicals within se... be made in response to terrorist threats. , Th...
(Date:11/18/2009)... in data analysis combined with Bio-Rad,s Biot...urricula provide state-of-the-art solutions to bio... 18 Vernier Software & Technol... sensors, and software and Bio-Rad Laboratories, I...of life science research and clinical diagnostics ...
(Date:11/18/2009)...ssex, U.K. and CLEVELAND, Nov. 18 ...siness and premier provider of diagnostic systems ... has expanded its East Grinstead, U.K., manufactur...increasing global demand for its Sensititre® ... testing. The expanded facility has been fully val...
Breaking Biology Technology:New NIST trace explosives standard slated for homeland security duty 2New technology detects chemical weapons in seconds 2Vernier and Bio-Rad to Offer Enhanced Solutions for Biotechnology Education 2TREK Diagnostic Systems Opens New U.K. Facility in East Grinstead to Meet Expanded Customer Demand for Microbiology Products 2TREK Diagnostic Systems Opens New U.K. Facility in East Grinstead to Meet Expanded Customer Demand for Microbiology Products 3TREK Diagnostic Systems Opens New U.K. Facility in East Grinstead to Meet Expanded Customer Demand for Microbiology Products 4
...s to HistoRx AQUA(R) technology for ...ch 26 HistoRx, Inc. announced,today that it has s...mpany,(NYSE: LLY ) to make the HistoRx AQUA(R) te...lable to Lilly researchers and clinicians involved...ical development. The,agreement extends and signif...
...se I/II trial TSX symbo...- SemBioSys Genetics Inc.,(TSX: SBS), a biotechnol...proteins for metabolic and cardiovascular diseases...gy study in animals to demonstrate the safety and,... pharmaceutical grade,human insulin. This study is...
...RNewswire-FirstCall/,-- Evotec AG (Frankfurt Stock...WKN 566480) announced today that the U.S. Securiti...ctive Evotec,s Registration Statement on,Form F-4,...r transaction,with Renovis, Inc., a South San Fran...he discovery and development of drugs for major me...
Other Biology Technology:HistoRx and Lilly Extend, Expand AQUA(R) Analysis Partnership 2HistoRx and Lilly Extend, Expand AQUA(R) Analysis Partnership 3SemBioSys initiates toxicology study for safflower-produced insulin 2SemBioSys initiates toxicology study for safflower-produced insulin 3Evotec's Registration Statement in Connection With its Proposed Acquisition of Renovis Declared Effective 2Evotec's Registration Statement in Connection With its Proposed Acquisition of Renovis Declared Effective 3
(Date:11/22/2009)...tterfly,s proboscis looks like a straw -- long, sl...ike a paper towel, according to Konstantin Kornev ...ks of this piece of insect anatomy to make small p..., Kornev will present his work next week at the 6...y,s (APS) Division of Fluid Dynamics will take pla...
(Date:11/22/2009)...artnership of the University of British Columbia F...search Institute, have uncovered new information a...ing a stroke, as well as a possible way to mitigat...tly published online in Nature Medicine . , Fol...even after blood flow has been restored. Researche...
(Date:11/20/2009)...tific and technological frontiers. The National Sc...t totals nearly $4.3 million for the diverse effor...an Recovery and Reinvestment Act of 2009. , Fo...igation of solar phenomena. Philip R. Goode, disti...pabilities of NJIT,s Big Bear Solar Observatory wi...
Breaking Biology News(10 mins):New understanding about mechanism for cell death after stroke leads to possible therapy 2NJIT receives NSF funding to improve Big Bear Telescope, study solar energy 2Mesoone com Launches Official Portal With Access To Effective And Affordable Mesotherapy Products 58916 1Mesoone com Launches Official Portal With Access To Effective And Affordable Mesotherapy Products 58916 2Galenea Awarded RC1 Challenge Grant to Develop Predictive In Vivo Models of Cognition 58911 1Galenea Awarded RC1 Challenge Grant to Develop Predictive In Vivo Models of Cognition 58911 2Continuing racial differences in HIV prevalence in US 58907 1Continuing racial differences in HIV prevalence in US 58907 2Continuing racial differences in HIV prevalence in US 58907 3
... (ACS) News Service Weekly PressPac with news from...neering News.,Please credit the individual journal...r this information. , ALL CONTENT IS FOR IMMEDIAT...A. M., Eastern Time, Jan. 14, 2008. , , ARTICLE ... promise for monitoring pollutants from oil spills...
...y of 20,000 people found seven new genes that infl...heart disease, and confirmed 11 other genes previ...ternational study led by researchers from the Univ... to identify or confirm genetic variants that infl...variants were linked to the decreased or increased...
...eland,Security (DHS) announced today that it has b...national visitors arriving at Hartsfield-Jackson,A...nge is part of the,department,s upgrade from two- ...nd facilitate legitimate travel by more accurately...rs, identities., "Biometrics have revolutionized ...
Other Biology News:American Chemical Society's weekly PressPac -- Jan. 9, 2008 2American Chemical Society's weekly PressPac -- Jan. 9, 2008 3American Chemical Society's weekly PressPac -- Jan. 9, 2008 4American Chemical Society's weekly PressPac -- Jan. 9, 2008 5American Chemical Society's weekly PressPac -- Jan. 9, 2008 6American Chemical Society's weekly PressPac -- Jan. 9, 2008 7American Chemical Society's weekly PressPac -- Jan. 9, 2008 8American Chemical Society's weekly PressPac -- Jan. 9, 2008 9Study locates cholesterol genes; finds surprises about good, bad cholesterol 2DHS Begins Collecting 10 Fingerprints From International Visitors at Hartsfield-Jackson Atlanta International Airport 2
Dispensing Bins from Terra Universal, Inc.
7500 Series ICP-MS ChemStation Upgrade from Agilent Technologies
Safety Glasses Dispensers from Terra Universal, Inc.
Apparel Dispenser from Terra Universal, Inc.
Biology Products: