Navigation Links
Phosphagenics Announces Successful Phase 1 Transdermal Oxycodone Clinical Trial Results
Date:12/17/2007

MELBOURNE, Australia, Dec. 17 /PRNewswire-FirstCall/ -- Phosphagenics Limited ("Phosphagenics") (ASX: POH, AIM: PSG, OTCQX: PPGNY) today announced positive results of its Phase 1 clinical trial that showed its delivery technology, TPM, delivered leading pain-relief drug oxycodone through the skin without causing disruption or irritation of any kind.

These results support Phosphagenics' aims to be the first company to commercialize a sustained release oxycodone patch for the management of chronic pain.

"Oxycodone, with worldwide annual sales of more than $1 billion, is more potent than morphine with fewer adverse effects; however, oxycodone is not available transdermally due to serious issues relating to skin sensitization and irritation," said Dr. Esra Ogru, Executive Vice President of Research and Development at Phosphagenics. "Our trial results show that TPM can deliver oxycodone through the skin in a sustained release formulation without causing skin irritation."

This trial, which was conducted by CMAX (an independent clinical research organization located at the Royal Adelaide Hospital) was a single-centre, single-blinded, pharmacokinetic trial in 16 healthy subjects. The trial endpoints were to evaluate the safety and tolerability of the TPM/Oxycodone formulation and the ability of the TPM technology to deliver oxycodone into the body.

The oxycodone, administered as a single transdermal application, was safe with no adverse events reported. Oxycodone was detected in the subjects for at least 48 hours. The results demonstrate that the formulation is bioavailable and effective in delivering oxycodone into the body.

A collaborative program is now under way with a world leading patch development company to incorporate the current formulation into a patch system. Plans are also underway to undertake a pivotal clinical study in the first half of 2008.

"Developing our pain relief pipeline builds on the success of Phosph
'/>"/>

SOURCE Phosphagenics Limited
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. YM BIOSCIENCES ANNOUNCES COMPLIANCE WITH AIM RULE 26
3. Emisphere Technologies, Inc. Announces Pricing of Registered Direct Offering
4. BioLife Solutions Announces Exclusive CryoStor(TM) Supply Agreement With the New England Cryogenic Center, Inc.
5. Carrington Announces Nasdaq Communication; Prepares for Shares to Be Quoted on the OTC Bulletin Board and Pink Sheets
6. China Kangtai Cactus Biotech Files 2nd Quarter 2007 10QSB and Announces Unaudited Quarterly Results
7. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
8. Advanced Life Sciences Announces Receipt of Nasdaq Staff Letter
9. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
10. Angiotech announces additional diameters of sutures to further expand its Quill(TM) SRS PDO product line
11. CNS Response Announces Fiscal Third Quarter 2007 Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... September 30, 2014 The ... IACRN), a non-profit organization based in Pittsburgh, Pennsylvania, ... and Safety (ACRES), a Massachusetts non-profit charitable ... alliance agreement, setting the stage for multiple collaborative ... clinical research quality and safety through specialized nursing ...
(Date:9/29/2014)... Sept. 29, 2014 Research and Markets ... Market by Product & Services, End-User , Application - ... The global oligonucleotide synthesis market is ... million in 2014, growing at a CAGR of 9.8% ... is categorized on the basis of products and services, ...
(Date:9/29/2014)... 2014 According to ... Product (Modifying Enzymes, DNA Polymerase, Acetylase, Methyltransferase, ... Reagents), by Research Area (Developmental Biology, Oncology), ... 2019", published by MarketsandMarkets, provides a detailed ... current market trends, and strategies impacting the ...
(Date:9/29/2014)... , Sept. 29, 2014 /PRNewswire/ - SQI Diagnostics ... that develops and commercializes proprietary technologies and products for ... of Peter Winkley to Chairman of the ... .  Mr. Ricks will continue to serve as a ... leadership to the Company.  "We are ...
Breaking Biology Technology:IACRN and ACRES to Support Clinical Research Nurses 2IACRN and ACRES to Support Clinical Research Nurses 3Oligonucleotide Synthesis (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) Market - Global Forecast to 2019 2Oligonucleotide Synthesis (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) Market - Global Forecast to 2019 3Epigenetics Market Worth $783.17 Million by 2019 2Epigenetics Market Worth $783.17 Million by 2019 3Epigenetics Market Worth $783.17 Million by 2019 4SQI Diagnostics Announces New Chairman of Board of Directors 2
... By Julia Cino, PhD , ... Introduction , ... manipulate DNA to identify,excise, move and place genes into a variety of ... for many of these recombinant organisms is to produce,proteins. Since many proteins ...
... , ... , ... protocols for culturing cells in a BioFlo 110,benchtop fermentor/bioreactor system. ... control modules to enable growth of,a wide variety of cultures, including mammalian, ...
... , , ... This Application Report is part of a series documenting,culture growth in the ... well as mammalian,plant cells and insect cells., , ... , Pichia pastoris ...
Cached Biology Technology:High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 2High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 3High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 4High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 5High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 6High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 7High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 8Hybridoma Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 2Hybridoma Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 3Hybridoma Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 4Hybridoma Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 5Hybridoma Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 6P. pastoris Fermentation using a BioFlo 110 Benchtop Fermentor 2P. pastoris Fermentation using a BioFlo 110 Benchtop Fermentor 3P. pastoris Fermentation using a BioFlo 110 Benchtop Fermentor 4P. pastoris Fermentation using a BioFlo 110 Benchtop Fermentor 5P. pastoris Fermentation using a BioFlo 110 Benchtop Fermentor 6P. pastoris Fermentation using a BioFlo 110 Benchtop Fermentor 7P. pastoris Fermentation using a BioFlo 110 Benchtop Fermentor 8
(Date:9/29/2014)... inaccessible or esoteric. Yet in the modern world, it ... lives and a decisive role in the discovery and ... , UC Santa Barbara,s Paul Atzberger, a professor in ... mechanical engineering, often works in areas where science and ... the Proceedings of the National Academy of Science ...
(Date:9/29/2014)... dinosaurs, gigantic reptilesdistant relatives of modern crocodilesruled the earth. ... it was thought they didn,t much interact. But a ... in the thigh of one of these ancient animals ... earth and planetary sciences lecturer, and her Virginia Tech ... marks in the thigh bones of an old reptile ...
(Date:9/29/2014)... , Canda, September 29, 2014 ... Such as UID Coupled with Increasing Security Concerns ... India is one ... witnessing increasing adoption of biometrics systems, majorly in ... e-drivers, NREGA, etc. Fingerprint modality based biometrics dominates ...
Breaking Biology News(10 mins):At the interface of math and science 2At the interface of math and science 3At the interface of math and science 4Tooth serves as evidence of 220 million-year-old attack 2India Biometrics Market to Surpass USD2.7 Billion by 2019, Finds TechSci Research Study 2India Biometrics Market to Surpass USD2.7 Billion by 2019, Finds TechSci Research Study 3
... by fungi, bacteria, and algae, is a common component of ... the medical field it,s approved by the FDA as ... surgery as a substance that opens the blood/brain barrier to ... Gazit and Daniel Segal of Tel Aviv University,s Department of ...
... controversial method of mining shale gas, is widespread across Pennsylvania, ... research in the Annals of the New York Academy ... pollution from toxic chemicals, the building of well pads and ... a great deal of controversy, largely because of its impact ...
... 116 million years ago triggered a similar marine ecosystem ... result of global warming, according to research published today ... experts from the universities of Newcastle, UK, Cologne, Frankfurt ... a crash in the marine ecosystem during the mid-Cretaceous ...
Cached Biology News:Artificial sweetener a potential treatment for Parkinson's disease 2Global cooling as significant as global warming 2
Taq DNA polymerase, 10,000U...
... - 5 units/µL ,• High specific activity ... Leaves an 'A' overhang ,• Processes ... very high activity in primer extension and ... quality of the enzyme, each lot has ...
... a versatile and easy-to use enzyme, with ... Taq DNA Polymerase is prepared from a ... the DNA polymerase I gene from Thermococcus ... 5'-3' DNA polymerase activity. Its inherent 3'-5' ...
A robust formulation of Taq Polymerase supplied with a 10X colored reaction buffer which allows Direct Gel-Loading...
Biology Products: