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Phenomix and Forest Laboratories to Collaborate on Development and Commercialization of Dutogliptin in Diabetes
Date:10/23/2008

been eager to find a product with a promising and novel mechanism that we could acquire to develop and market. We believe that Phenomix' DPP-4 inhibitor is a valuable addition to the available treatments to help better control this serious condition," said Howard Solomon, Chairman and Chief Executive Officer of Forest. "Diabetes is treated to a large extent by primary care physicians, with whom the Forest sales force has been particularly successful. We are pleased to work with Phenomix, whose management and scientific team have demonstrated ingenuity and commitment in bringing dutogliptin from discovery into late-stage clinical development."

"Partnering with Forest is a very important next step for Phenomix in working towards commercialization of dutogliptin for the treatment of patients with Type 2 diabetes," said Laura K. Shawver, Ph.D., Phenomix' Chief Executive Officer. "Forest has a demonstrated capability to develop and commercialize late-stage, large-market compounds, which will help ensure that dutogliptin will be a medically important and commercially successful drug. We are excited that Forest shares our vision and dedication to commercialize dutogliptin for the treatment of this devastating disease."

By comparison to placebo, dutogliptin demonstrated significant reductions in hemoglobin A1c (HbA1c) and fasting plasma glucose in a 12-week Phase 2b clinical study. The study also showed dutogliptin was well tolerated with a low incidence of adverse events. Dutogliptin was administered orally, once daily. Phenomix initiated a Phase 3 clinical development program in the third quarter of 2008. A composition of matter patent application has issued for dutogliptin, which provides protection to 2024, and is subject to extension.

About Diabetes

Diabetes is characterized by high levels of blood glucose due to inadequate production or action of insulin. It can lead to serious medical complications and death. In the United States, more tha
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SOURCE Forest Laboratories, Inc.
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