Navigation Links
Phase I Results Announced for R1507 From Genmab's Collaboration With Roche
Date:10/23/2007

Roche Releases Positive Phase I Results for R1507

COPENHAGEN, October 23 /PRNewswire-FirstCall/ -- Genmab A/S (OMX: GEN) announced today positive results from a Phase I study of R1507 in patients with solid tumors, conducted by its partner Roche. R1507 is a human monoclonal antibody targeting the insulin-like growth factor receptor (IGF-1R) and was developed under Roche's collaboration with Genmab.

Nine of 34 adult patients with solid tumors experienced disease stabilization when treated with R1507. Four of the seven heavily pretreated patients with Ewing's sarcoma demonstrated clinical benefit with two of these patients achieving durable, objective partial responses.

Once a week administration of R1507 was well tolerated with few side effects. The most frequently observed side effects were fatigue, anorexia and weight loss, symptoms that are commonly observed in patients with advanced cancer. A similar side effect profile was seen in 26 patients who were treated with R1507 on a three week schedule.

The results were reported during the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in San Francisco, California, USA. Further details can be found at http://www.rocheusa.com.

"These are the first clinical results to be presented from an antibody developed by Genmab under our collaboration with Roche," said Lisa N. Drakeman, Ph.D. "We are pleased with these positive results and hope it may offer a potential treatment for sarcoma patients in the future."

Based on these initial results with R1507, Roche plans to conduct additional trials and work with a global consortium of sarcoma experts, including the Sarcoma Alliance for Research through Collaboration (SARC).

About IGF-1R

IGF-1 is one of the most potent natural activators of the AKT and MAPK signaling pathways, which promote cell growth and cell survival. The IGF-1R
'/>"/>

SOURCE Genmab A/S
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. Protocol for RNA Isolation Using TRIzol Reagent with Phase Lock Gel-Heavy
2. Protocol for RNA Isolation Using TRIzol Reagent with Phase Lock Gel-Heavy
3. Easy preparation of total RNA from cultured cells with TRIzol and Eppendorf Phase Lock Gel
4. Identification of cells in S phase using the Cell Proliferation Fluorescence Kit and IN Cell Analyzer 1000
5. Direct Monitoring of Solid-Phase Peptide Synthesis by MALDI-TOF MS
6. Separation and Quantitation of R and S Enantiomers using Normal Phase Chromatography on an API 3000 LC/MS/MS System
7. Identification of Phase I and Phase II Metabolites of Buspirone on the Q TRAP LC/MS/MS System
8. Strategies to Identify and Confirm Phase I Metabolites of Glyburide Using the 4000 Q TRAP System
9. ANALYSIS OF AMINO ACIDS BY REVERSED PHASE CHROMATOGRAPHY WITH PRECOLUMN DERIVATISATION AND UV/VISIBLE DETECTION
10. Novel Bonding Chemistry Imparts Enhanced Polar Selectivity to TSK-GEL ODS-100V Reversed Phase Columns
11. Mobile Phase Optimization for the Analysis of an Antibody-Based Fusion Protein and Aggregates using a TSKgel Super SW3000 Size-Exclusion Column

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2009)...re-Asia/--ShanghaiBiolaxyannouncedthe,ChineseState...vestigationalnewdrugapplication(IND)foritsoralinsu...totreatdiabetes.ThisIND,approvalallowsBiolaxytoini...sadisordercharacteristicofhighbloodglucoseandpoor,...severemicro-and,macro-vasculardiseases,lossofvisio...
(Date:11/24/2009)...RONTO,Nov.24/PRNewswire-FirstCall/-HamiltonThorneL...providerofadvancedlasersystemsandinstrumentsforthe...ortedoperationalandfinancialresultsforthethirdquar...evenuewas$1.46millioncomparedwith$1.43millioninQ32....1percentinQ3,2008,-Netlossreducedto$148,000compar...
(Date:11/24/2009)...RNewswire/--HealthRoboticstodayannounced,thatithas...,investors.ThisrecentlyformedToronto-basedcompanyw...dwillmarket,install,andsupport,HealthRobotics,i.v....aryproductofferingsi.v.STATION(TM),i.v.SOFT(TM),an...ssistanceonan"asneeded,basis"toitsstrategicpartner...
(Date:11/23/2009)... In a provocative new study, a University of Utah...ions the major cause of global warming cannot be...r society builds the equivalent of one new nuclear...t there will be any substantial near-term departur...oxide emission rates," says the new paper by Tim G...
Breaking Biology Technology:Biolaxy Secures IND Approval for Oral Insulin 2Hamilton Thorne announces third quarter results 2Hamilton Thorne announces third quarter results 3Hamilton Thorne announces third quarter results 4Hamilton Thorne announces third quarter results 5Hamilton Thorne announces third quarter results 6Hamilton Thorne announces third quarter results 7Health Robotics Continues its Global Expansion With December 09 ASHP's Launch of Joint Venture in Canada 2Is global warming unstoppable? 2Is global warming unstoppable? 3Is global warming unstoppable? 4
...CO, Nov. 12 VIA Pharmaceuticals,(Nasdaq: VIAP ),...t of,compounds for the treatment of cardiovascular...nical advisory board. Joining the clinical advisor...rofessor of Medicine,Harvard Medical School, and S...ton, and Jean-Claude Tardif, M.D., Associate Profe...
...Sought for Breakthrough Pain Associated with Chron...Taking Opioid Medications ...on, Inc. (Nasdaq:,CEPH) today announced it has sub...to the U.S. Food and Drug Administration (FDA) see...l tablet) [C-II] for the management of,breakthroug...
..., N.J. -- The Edwin A. Stevens Society of Stevens ...ean of Stevens School of Systems and Enterprises, ...ward at its annual Gala, to be held at the Park Av...g at 7:00 p.m. Attendance at the black-tie event i...ward is presented to a distinguished individual wh...
Other Biology Technology:VIA Pharmaceuticals Expands Clinical Advisory Board With Leading Experts in Cardiovascular Disease 2VIA Pharmaceuticals Expands Clinical Advisory Board With Leading Experts in Cardiovascular Disease 3VIA Pharmaceuticals Expands Clinical Advisory Board With Leading Experts in Cardiovascular Disease 4Cephalon Submits Supplemental New Drug Application for FENTORA 2Cephalon Submits Supplemental New Drug Application for FENTORA 3Cephalon Submits Supplemental New Drug Application for FENTORA 4Cephalon Submits Supplemental New Drug Application for FENTORA 5Cephalon Submits Supplemental New Drug Application for FENTORA 6Cephalon Submits Supplemental New Drug Application for FENTORA 7Dr. Dinesh Verma to be honored with President's Leadership Award at Edwin A. Stevens Society Gala 2Dr. Dinesh Verma to be honored with President's Leadership Award at Edwin A. Stevens Society Gala 3
(Date:11/25/2009)...duced in the stomach, may be used to boost resista...sease, Yale School of Medicine researchers report ...rnal of Neuroscience . , Parkinson,s disease is ... area of the midbrain known as the substantia nigr...Reduced production of dopamine in late-stage Parki...
(Date:11/25/2009)...25, 2009 Soil is the linchpin of the environment,.... Despite that, many students see soil as "just di...l science educators are challenged with the task o...itical importance of soil in the environment. , ... science teachers at University of Nebraska-Lincol...
(Date:11/24/2009)... it has been prescribed by traditional healers in ... and stomach pain to fever and flu. , Now for the...ave been able to scientifically prove the pain rel...nown as Brazilian mint. , Testing this ancient So...her Graciela Rocha was able to show that when prep...
Breaking Biology News(10 mins):Hormone ghrelin can boost resistance to Parkinson's disease 2It's not just dirt! 2Got a pain? -- Have a cup of Brazilian mint 2Announcing 3A Millennium Place Transitional Downtown Living for Women With Eating Disorders 55578 1Announcing 3A Millennium Place Transitional Downtown Living for Women With Eating Disorders 55578 2More Than Four Out of Five Dentists Surveyed Reveal That Texting During Dental Treatment a Common Problem 55576 1More Than Four Out of Five Dentists Surveyed Reveal That Texting During Dental Treatment a Common Problem 55576 2Flu Expert Helps Clear the Confusion About H1N1 Vs Seasonal Flu Vaccination 55574 1Flu Expert Helps Clear the Confusion About H1N1 Vs Seasonal Flu Vaccination 55574 2
...octoral fellow at the University of Oregon, has sh...y of legumes to recruit soil bacteria needed to pr...rsity of Oregon Many farmers applying pesticides ...o growth problems, scientists report in a new stud...test tube and, now, with real plants, a team of sc...
...y in developing countries are being denied an effe...ng to an editorial in this week’s BMJ. , Professor...ntal organisations in developing countries to ensu... , Of the 35 million people with epilepsy who li...treatment at all. As a result, they experience sei...
...ered new clues to a very cold case: the disappeara...conic of all Ice Age giants, according to a June 7...ublication of Cell Press. , DNA lifted from the bo...aled a “genetic signature” of a range expansion af...hs’ migration, the population apparently leveled o...
Other Biology News:Pesticides choke pathway for nature to produce nitrogen for crops 2Pesticides choke pathway for nature to produce nitrogen for crops 3Ancient DNA traces the woolly mammoth's disappearance 2
Rabbit Anti-NPM1 Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.
EZ-96 DNA Methylation-Gold Kit from Zymo Research
Acrylamide PAGE 40% Solution from GE Healthcare, formerly Amersham Biosciences
Kinase Chemiluminescent Assay Kit from Upstate
Biology Products: