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Phase 1 Studies Show Promise of QuatRx's Novel Compound, Sobetirome, for Lowering LDL Cholesterol Levels
Date:1/29/2008

the multiple dose study of 24 subjects over two weeks, reductions in LDL cholesterol levels decreased up to 41% at doses up to 100 micrograms once a day, compared to an overall 5% reduction for placebo. Subjects, who were not enriched for LDL levels, followed a low-cholesterol diet starting one week prior to randomization and then received sobetirome or placebo. Sobetirome was generally well tolerated in both studies.

In published preclinical studies in primates, sobetirome has been shown to lower LDL cholesterol and Lp(a) and to promote weight loss. Lp(a) is a lipoprotein that is associated with an increased risk of stroke and coronary heart disease. In preclinical studies in mice, sobetirome also stimulated steps of reverse cholesterol transport. This process involves the transport of cholesterol from peripheral tissues to the liver for conversion into bile acids and then excretion from the body.

LDL Cholesterol, Cardiovascular Disease and Current Treatments

High LDL cholesterol levels have been shown to increase the risk of cardiovascular disease including coronary heart disease and stroke. Approximately 70 million Americans have some form of cardiovascular disease, according to the American Heart Association. Lowering LDL cholesterol to reduce cardiovascular risk is a primary focus of currently available lipid regulating therapies, of which statins are the most frequently prescribed class. While statins have been shown to lower LDL levels in many people with high LDL cholesterol, some patients are unable to tolerate statins due to side effects and many others fail to reach their LDL treatment targets in treatment involving statins alone. In addition, a substantial number of patients with elevated LDL levels also have other cardiovascular risk factors such as obesity, high Lp(a) and high triglycerides, which are not adequately addressed by statin therapy. In all of these sizable patient sub-populations, there is a need for new treatment optio
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SOURCE QuatRx Pharmaceuticals
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