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Pharmacyclics Reports Fourth Quarter and Fiscal 2008 Financial Results
Date:8/14/2008

m a preclinical study evaluating PCI-32765, an

orally available, selective inhibitor of Bruton's tyrosine kinase,

or Btk, in collagen induced arthritis, an established animal model

for rheumatoid arthritis (RA). Treatment of animals with advanced

disease, with PCI-32765 reduced inflammation and induced regression

of disease.

* Filed an investigational new drug (IND) application for PCI-27483, a

small molecule inhibitor of Factor VIIa being developed both for the

treatment of thrombotic complications of cancer and as an

anti-cancer agent.

* Plan to complete enrollment and evaluation of a Phase 1 trial in

normal volunteers with our Factor VIIa inhibitor, PCI-27483, in the

fourth quarter of calendar 2008.

* Plan to initiate a Phase 1 trial with our oral Btk inhibitor,

PCI-32765, in patients with recurrent B-cell lymphoma in the fourth

quarter of calendar 2008. This study is designed to evaluate safety

and efficacy using a novel pharmacodynamic biomarker.

* Plans are underway to design and conduct a pivotal Phase 3 trial

with motexafin gadolinium in patients with brain metastases from

non-small cell lung cancer receiving whole brain radiation and

stereotactic radiosurgery. This trial is anticipated to begin in the

first half of calendar 2009.

Conference Call and Webcast Details

The Company will hold a conference call today at 4:30 p.m. EDT to discuss fiscal 2008 year-end financial results and achievements and fiscal 2009 guidance. To participate in the conference call, please dial 800-497-0451 for domestic callers and 706-758-3306 for international callers and reference conference passcode 59146626. To access the live audio broadcast or the subsequent archived recording, log on to

SOURCE Pharmacyclics, Inc.
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