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Pharmacoeconomic Analysis Shows SURFAXIN® May Reduce Hospital Cost Associated with Reintubation in Premature Infants
Date:5/1/2012

lving a total of 1546 patients shows that the reintubation rate in SURFAXIN-treated infants ranged from 33 to 35 percent and was significantly lower (p < 0.05) compared with treatment with Curosurf (47 percent), the current global market leader, and Survanta (43 percent).  These data were previously published in the Journal of Neonatal- Perinatal Medicine (Volume 4, Number 2, 2011) in a manuscript entitled "Reintubation and risk of morbidity and mortality in preterm infants after surfactant replacement therapy" (Guardia et al.).  Based on these data, pharmacoeconomic modeling reveals that the higher rates of reintubation observed with the use of Curosurf and Survanta also results in potential increases in direct hospital costs related to the need for extended mechanical ventilation and the daily cost of care for these infants.  Although the retrospective analysis also demonstrates that reintubation results in an increase in morbidities, such as bronchopulmonary dysplasia and air leak, the pharmacoeconomic modeling does not include the additional costs associated with these morbidities.  The study authors noted that additional pharmacoeconomic analyses of potential reduction in reintubation-associated morbidities are warranted.

Dr. Clayton continued, "Analysis of our phase 3 data has already demonstrated that reintubation appears to be related to higher mortality as well as increases in key morbidities.  These observations, along with the results of this pharmacoeconomic analysis, represent important information for neonatal health care providers to consider when choosing a surfactant for their patients."

Discovery Labs estimates that approximately 360,000 low birth weight premature infants are born annually in the United States and at risk for RDS.  Of that total, the Company estimates that approximately 130,000 are diagnosed with RDS and nearly 90,000 are treated with surfactant replacement ther
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SOURCE Discovery Laboratories, Inc.
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