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PharmAthene Presents Data for Valortim(R) Anthrax Anti-Toxin and Third Generation rPA Anthrax Vaccine Programs at the Bacillus - ACT 2009 Conference
Date:9/3/2009

formulation lacking this adjuvant. Results showed that animals immunized with these formulations, whether supplemented with the adjuvant or not, were fully protected against challenge with 10(3 )median lethal doses of B. anthracis at day 21.

These preliminary data suggest that PharmAthene's 3G product prototype may be able to provide both faster time to immunity and significantly enhanced immunogenicity, indicating that the optimized formulation may be able to reduce the requirement for multiple vaccine doses, and simplify the immunization regimen for anthrax vaccines in the future.

Funding for this study was provided under a Challenge grant from the National Institutes of Health. The data from this study are intended to inform ongoing efforts in PharmAthene's 3G rPA program. In September 2008, PharmAthene was awarded a development contract from the National Institute of Allergy and Infectious Diseases (NIAID) of up to $83.9 million for the 3G rPA vaccine program, provided the government exercises all contract options at its sole discretion.

About Anthrax

According to the Centers for Disease Control and Prevention, anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. Anthrax most commonly occurs in hoofed mammals and can also infect humans. Symptoms of disease vary depending on how the disease is contracted, but usually occur within seven days after exposure. The serious forms of human anthrax are inhalation anthrax, cutaneous anthrax, and intestinal anthrax. Initial symptoms of inhalation anthrax infection may resemble a common cold. After several days, the symptoms may progress to severe breathing problems and shock. Inhalation anthrax is often fatal, even if treated by antibiotics. Currently, antibiotics are the only drugs available for therapeutic or prophylactic use for inhalation anthrax, and post-exposure prophylaxis is the o
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