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PharmAthene Presents Data for Valortim(R) Anthrax Anti-Toxin and Third Generation rPA Anthrax Vaccine Programs at the Bacillus - ACT 2009 Conference
Date:9/3/2009

seases.

Third Generation (3G) rPA Anthrax Vaccine Findings Reported

Various government agencies, including the Institute of Medicine, have acknowledged the urgent need to stockpile next-generation anthrax vaccines employing modern vaccine technology, which offer the potential for improved safety and convenience, as well as enhanced characterization and lot-to-lot consistency. PharmAthene's portfolio includes both second and third generation rPA anthrax vaccine candidates, which incorporate significant product development and technological advancements and are designed to meet these requirements. The Company's second generation rPA anthrax vaccine, SparVax(TM), is currently under consideration for a major advanced development and procurement contract through the Biomedical Advanced Research and Development Agency.

The goal of PharmAthene's third generation (3G) rPA vaccine program is to develop a vaccine formulation which can induce a more rapid onset of protective immunity in fewer doses, and can be stored, transported and used without the need for a conventional cold chain - an important advantage for civilian biodefense deployment within the Strategic National Stockpile.

In a poster entitled, "Faster Time to Immunity and Enhanced Immune Response to Optimized rPA Vaccine," Allan Watkinson, R&D Director & Principal Investigator, PharmAthene UK, presented results from a mouse model in which PharmAthene and its collaborators investigated incorporating an additional immunostimulant adjuvant into a prototype 3G product formulation.

In the study, female mice were immunized in four treatment groups of 30 and blood samples were taken on days 14, 21 and 28. When immunization of mice with the lyophilized formulation of rPA was supplemented with the immunostimulant adjuvant, a significantly enhanced (p<0.005) anti-PA titre was induced, compared with the equivalent
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SOURCE PharmAthene, Inc.
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