ANNAPOLIS, Md., March 6 /PRNewswire-FirstCall/ -- PharmAthene, Inc., a biodefense company specializing in the development and commercialization of medical countermeasures against chemical and biological threats, announced today that it has completed the initial pharmacokinetic (PK) testing of Protexia(R), the Company's broad spectrum chemical nerve agent prophylaxis.
The PK studies were conducted in two animal species and used the final pegylated version of rBChE for the first time. In general, the conjugation of proteins with polyethylene glycol (PEG) has been shown to decrease immunogenicity, increase circulating serum half-life and increase stability of recombinant proteins. The data from these studies confirm that the specific PEG chosen for conjugation to rBChE will significantly improve the half-life of the protein in vivo.
The PK studies demonstrated that Protexia(R) had a half life of approximately four days in primates and three days in rodents when administered by intramuscular injection. These data compare favorably with what was predicted for the drug's PK profile in these animal species.
John Troyer, Ph.D., Senior Program Director for Protexia(R), commented, "These results are very meaningful in that they show that Protexia(R) meets or exceeds our target product profile for use as a chemical nerve agent prophylaxis. The impressive half life data also confirm that the pegylation of rBChE as part of our manufacturing process achieved the goal of extending the half-life of the protein to one which makes it a feasible product for use in humans."
Dr. Troyer continued, "Having successfully completed the PK studies, we are on target to complete our toxicology studies and file the Investigational New Drug (IND) application for Protexia(R) in the third quarter of 2008; we expect to commence Phase I human safety testing of Protexia(R) in the fourth quarter."
"Today's announcement highlights the intense commitment and stro
|SOURCE PharmAthene, Inc.|
Copyright©2008 PR Newswire.
All rights reserved