Navigation Links
Permeon reveals discovery of Intraphilins as new approach to intracellular biologic drugs
Date:7/29/2011

Permeon Biologics, a biopharmaceutical company pioneering a novel class of intracellular protein biologics, today announced the discovery of an entirely new class of naturally occurring human supercharged proteins called Intraphilins. The sequence and structure of these naturally supercharged human proteins enable biologic drugs to penetrate and function inside of mammalian cells. This new class of proteins is the foundation of Permeon Biologics' novel Intraphilin Technology Platform and provides an innovative approach to develop intracellular protein biologic drugs, such as intracellular monoclonal antibodies and enzyme replacement therapies. Intraphilins enable functional proteins to act inside cells to treat disease, impacting over 1,500 intracellular target proteins currently considered undruggable with available technologies.

The data were published online today in the journal Chemistry & Biology in a seminal paper by David R. Liu, Ph.D., professor of chemistry and chemical biology at Harvard University and investigator at the Howard Hughes Medical Institute, and his colleagues. The findings represent natural scaffolds for developing potent human intracellular biologic drugs, and also raise the possibility that some of these supercharged proteins may penetrate cells as part of their native biological functions. The ability of human Intraphilins to penetrate cells to enable intracellular protein biologics has not been previously reported.

"The data show that naturally supercharged Intraphilin proteins already exist within the human body and can enable the delivery of protein biologics into mammalian cells in vivo," said Dr. Liu, Permeon's scientific founder and scientific advisory board chairman. "Intraphilins are now being developed as a new class of human protein therapeutics to access previously undruggable intracellular target proteins and pathways."

The study sought to determine if this class of proteins could provide
'/>"/>

Contact: Michele Rozen
617-730-8284
Pure Communications Inc.
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Whole sequence variation map reveals insight into evolutionary studies of rhesus macaque
2. New research reveals soil microbes accelerate global warming
3. DNA Sequencing Data Reveals New Hybrid E. coli Strain is Cause of German Outbreak
4. Combo method reveals cells signal systems
5. LasikPlusĀ® Research Reveals Excellent Results From Modern LASIK
6. Study of 90 animals thigh bones reveals how they can efficiently carry loads
7. Nanoscale probe reveals interactions between surfaces and single molecules
8. Major disease-vector mosquito reveals the secrets of its immune system
9. Health 2.0 Reveals the Winners of the 2010 Developer Challenge
10. Elsevier Survey Reveals Researchers Ready to Push Scientific Search and Discovery to the Next Level
11. Unprecedented look at oxide interfaces reveals unexpected structures on atomic scale
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... , May 05, 2015 Research and Markets ... addition of the "Clinical Laboratory, Molecular Diagnostics ... 2015 to 2019 - Europe Version" report ... especially in the area of molecular diagnostics and ... and evolving world market that is moving out ...
(Date:5/5/2015)... May 05, 2015 Exotic ... distributor, announces the launch of http://www.cng.exoticautomation.com , ... with a convenient way to purchase genuine OEM ... . , The new website provides owners ... with direct access to high performance products for ...
(Date:5/5/2015)... MA (PRWEB) May 05, 2015 The ... ), a Massachusetts-based non-profit operating in the public interest, ... affiliate of the Hearst Communications Company, have formed a ... for public outreach and education across the healthcare and ... for the voice of patients and the public to ...
(Date:5/4/2015)...   St. Jude Children,s Research Hospital ... for finding genetic alterations that play an important ... identify with whole-genome sequencing. The findings appear today ... The tool is an algorithm called ... Tree in Next Generation Sequencing. ...
Breaking Biology Technology:European Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market 2015-2019 2Exotic Automation & Supply Launches Ecommerce Website 2ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 2ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 3ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 4Scientists dramatically improve method for finding common genetic alterations in tumors 2Scientists dramatically improve method for finding common genetic alterations in tumors 3Scientists dramatically improve method for finding common genetic alterations in tumors 4
... Nov. 27 Corium International, Inc.,a privately-held transdermal ... Gardner, M.D. and Daniel G. Welch to the ... Essex Woodlands Health,Ventures, is a Professor of Medicine ... of cell biology and pharmacology. In addition to,her ...
... Therapeutics,(Nasdaq: FOLD ) today announced that it will host ... 7:00 PM at the Four Seasons Hotel in New,York City. ... the,Phase 2 clinical trials performed for Amigal(TM) (migalastat hydrochloride),for Fabry ... other,research and development programs at the company., A live ...
... an FDA 510(k) (Pre-Market Notification), Pathway for AppyScore(TM), the First Blood-based ... ... ROCK, Colo., Nov. 27 AspenBio Pharma,Inc. (Nasdaq: APPY ) ... diagnostics for animals and humans, has,received an official response from the ...
Cached Biology Technology:Corium International, Inc. Announces Appointment of Phyllis Gardner, M.D. and Daniel G. Welch to Board 2Corium International, Inc. Announces Appointment of Phyllis Gardner, M.D. and Daniel G. Welch to Board 3Amicus Therapeutics to Host R&D Day 2Amicus Therapeutics to Host R&D Day 3AspenBio Pharma Pursues FDA 510(k) Application Pathway for Appendicitis Blood Test 2AspenBio Pharma Pursues FDA 510(k) Application Pathway for Appendicitis Blood Test 3AspenBio Pharma Pursues FDA 510(k) Application Pathway for Appendicitis Blood Test 4
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... solutions, announced today that it will report financial results ... April 23, 2015, after the close of market. The ... and investors at 2:00 p.m. PT (5:00 p.m. ET), ... To participate on the live call, analysts and ...
(Date:4/2/2015)... , April 2, 2015 According ... 2015 attributed to somewhat higher than 125 MSEK. This ... year-end report 2014 that revenues for Q1 2015 would ... company reported for Q4 2014. The operating result for ... negative. The complete interim report will as previously communicated ...
(Date:3/31/2015)... 31, 2015   Guidepoint , a leading global ... Post-Surgical Pain Management TRACKER, part of the Guidepoint ... in the medical device and therapeutics markets. The Post-Surgical ... treatment volumes, market share, and adoption rates across three ... joint surgery. The Post-Surgical Pain Management TRACKER ...
Breaking Biology News(10 mins):Synaptics to Report Third Quarter Results on April 23 2Fingerprint Cards Revises Revenues for Q1 2015 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3
... Washington, DC Engineered nanoscale materials (ENMs), which ... use in food packaging, raise new safety evaluation ... report released today by the Project on Emerging ... The food-packaging industry, food companies and ...
... developed an effective technology for reducing contamination of dangerous ... Salmonella and E. coli O157:H7 on foods ranging from ... It is made from inexpensive and readily available ingredients ... and Drug Administration. The new technology, which ...
... Almost every June for 30 years, Terry McEneaney drove around ... three routes. Park ornithologist at the time, he would ... Then he,d drive another half mile, repeat the process and ... for the North American Breeding Bird Survey. Trying to finish ...
Cached Biology News:Use of nanomaterials in food packaging poses regulatory challenges 2New UGA invention effectively kills foodborne pathogens in minutes 2Bird watchers, space technology come together in Montana State University study 2Bird watchers, space technology come together in Montana State University study 3
... Services include: ,ISH Protocol ... Conditions Analyses ,RNA and DNA ... Cells and Tissues ,Double Labeling ... Cells and Tissues ,RNA and ...
Request Info...
IC50: 190 pg/ml · Limit of detection: 60 pg/ml...
Request Info...
Biology Products: