Navigation Links
PeriCor Therapeutics Reports Positive Preclinical Results of GP531 at the European Heart Failure Congress in Nice
Date:6/3/2009

represents a novel cardioprotective approach with a unique mechanism of action that addresses key functional maladaptations responsible for the worsening heart failure state." "The beneficial effects of GP531 were remarkably consistent within this study," noted David G. Shand, M.D., Ph.D., Senior Advisor for Clinical and Scientific Affairs. "The findings provide important insights for further evaluation of GP531 in heart failure." Results from these studies should be reported later this year and early next year. Richard Stover, President and CEO of PeriCor Therapeutics, Inc., added, "We are confident that these studies will provide additional insights into this novel approach to improve global myocardial function in patients with heart failure, and we plan to initiate a Phase II study of GP531 in acute decompensated heart failure during the second half of the year."

About GP531

GP531 is an adenosine regulating agent (ARA) that has been shown to amplify the body's broad-spectrum protective response -- the localized release of endogenous adenosine -- during episodes of cellular stress. Cellular stress, as occurs with ischemia and tissue hypoxia, triggers the breakdown of adenosine triphosphate (ATP). ATP is the key energy molecule of living cells. Endogenous adenosine has been termed a "retaliatory metabolite" that targets multiple pathways of cellular stress and myocardial injury to counter net ATP catabolism and, as such, acts as a key regulator of cellular energetics. Endogenous adenosine protects cells from multiple pathways of injury such as inflammation, apoptosis and necrosis. Endogenous adenosine levels have been shown to be elevated in heart failure patients but not sufficiently to be cardioprotective.

By augmenting a patient's own adenosine release in stressed tissues of the heart and its microvasculature, GP531 may have the potential to protect the heart muscle from further damage, alter the deterioration of
'/>"/>

SOURCE PeriCor Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. PeriCor Therapeutics Announces Closing of Licensing Agreement for Acadesine with Schering-Plough Corporation
2. PeriCor Therapeutics Appoints K. Tucker Andersen to Board of Directors
3. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
4. DJO Incorporateds Pending Merger With ReAble Therapeutics Clears U.S. Antitrust Review
5. Systems Medicine (SM), a Subsidiary of Cell Therapeutics, Inc. (CTI), Announces Execution of CRADA with NCI/NIH to Develop Potential Cancer Treatments Targeting the Insulin Growth Factor (IGF) Pathway
6. Amsterdam Molecular Therapeutics to Release H1 2007 Results on August 29, 2007
7. Nektar Therapeutics Appoints Tim Harkness as Chief Financial Officer
8. ExonHit Therapeutics: Allergan and ExonHits First Collaboration Compound to Begin Human Clinical Trials
9. Cell Therapeutics, Inc. Takes Corrective Actions in Response to Nasdaq Determination
10. Amsterdam Molecular Therapeutics Reports Half Year Results 2007
11. Nektar Therapeutics Appoints Lutz Lingnau as New Board Member
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2013)... , May 16, 2013 Scientists at the ... Beijing , and the California ... demonstrated a novel therapy for reversing memory decline in ... they find significant cognitive improvement in advanced stage AD ... mechanism for reversing cognitive decline for advanced stage AD ...
(Date:5/16/2013)... , May 16, 2013 /PRNewswire/ ... market research report is available in ... Competitor Analysis: Therapeutic Proteins ... http://www.reportlinker.com/p01171947/Competitor-Analysis-Therapeutic-Proteins-–-Biosimilars-Biobetters--Biosuperiors.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biopharmaceutical   ...   The new Competitive ...
(Date:5/16/2013)... May 16, 2013 DNA Genotek, a leading ... for Africa’, a sponsorship program in conjunction with the African ... to improve access and reduce the cost of DNA ... as the Human Heredity and Health in Africa (H3 Africa) ... , The aim of the AfSHG is to ...
(Date:5/16/2013)... New York, NY (PRWEB) May 16, 2013 ... PRMA Insights: Market Access Success for Companion Diagnostic–Drug ... the key issues that biopharmaceutical manufacturers should understand ... medicine is gaining traction, particularly in oncology, with ... NSCLC and Zelboraf for BRAF-mutation positive melanoma. Payors ...
Breaking Biology Technology:Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 2Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 3Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 2Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 3Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 4Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 5Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 6Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 7Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 8DNA Genotek Inc. Announces Spit for Africa Program 2DNA Genotek Inc. Announces Spit for Africa Program 3Market Access Expert Firm, PRMA Consulting, Launches Companion Diagnostics Handbook 2
... from around the world came together today to share their ... (CVBD) forum in Nice, France and call for greater awareness ... increasingly important diseases. "A number of the ... many CVBDs represent a zoonotic risk. It,s vital that veterinarians ...
... of our electronic age rests on our ability to ... point B, through circuitry. Doing so requires particular precision, ... cells, and that task falls to semiconductors. Now, ... of Engineering and Applied Science and Arts and Sciences ...
... at the Hilton San Francisco Union Square, Pam Marrone ... (MBI), will address Agriculture 2.0 conference attendees as ... a Growing Global Population,. The discussion will explore technologies with ... to feed a projected world population of 9 billion people ...
Cached Biology Technology:Veterinarians and Pet Owners Urged to Act Upon Evolving Dangers Posed by CVBDs as New Research Underlines Threats to Animals and Humans 2Veterinarians and Pet Owners Urged to Act Upon Evolving Dangers Posed by CVBDs as New Research Underlines Threats to Animals and Humans 3Veterinarians and Pet Owners Urged to Act Upon Evolving Dangers Posed by CVBDs as New Research Underlines Threats to Animals and Humans 4Penn research advances understanding of lead selenide nanowires 2Penn research advances understanding of lead selenide nanowires 3Pam Marrone to Speak at Ag 2.0 Conference 2
(Date:5/18/2013)... FL (May 18, 2013) An increasing number ... require interventions to resolve, according to research presented ... one study targeting obesity, researchers at the Cleveland ... a unique pattern of exhaled breath compared to ... volatile organic compound levels that can be correlated ...
(Date:5/17/2013)... 18, 2013) The AGA Research Foundation announced a ... relationship between the gut microbiota, one of today,s most ... , The AGA Research Awards Panel selected Andrew ... General Hospital and Harvard Medical School, Boston, as the ... Chan will receive $25,000 of funding, commencing in July ...
(Date:5/17/2013)... white noise of the South, but the night belongs to ... hangs heavy from the humidity and the sounds of wildlife. ... of frogs, toads and salamanders, is the center of amphibian ... are the auditorium for their symphonic choruses, the scientists of ... ARMI, have front-row seats. , Amphibians, which rely ...
Breaking Biology News(10 mins):New research identifies risks, interventions for children's GI health 2New research identifies risks, interventions for children's GI health 3New gut microbiome research to explore red meat -- colorectal cancer pathway 2Front-row seats to climate change 2Front-row seats to climate change 3Front-row seats to climate change 4
... Commercial flower and plant growers know all too ... the value and deterring healthy growth of potted ornamental ... to the expensive practice of paying workers to hand-weed ... is questionable on the wide range of plant species ...
... Tactile Sensors at Your Fingertips, Literally, ... Systems, Inc.,(PPS) today announces their innovative new ... immediate sale worldwide. FingerTPS,sensors are soft, flexible ... accurate,repeatable tactile force data to a PC ...
... reports from TRAFFIC, the world,s largest wildlife trade ... and Vietnam suggest that illegal wildlife trade, including ... the region,s rich and varied biodiversity and putting ... The results of field studies carried ...
Cached Biology News:Ethanol byproduct produces green results 2Wearable Sensors Conceived at Harvard Robotics Lab Measure Hand Forces 2A bitter pill to swallow 2
... useful for routine procedures. Hollandes contains formaldehyde ... will decalcify small bone specimens. Tissue that ... successfully with most stains, and the cupric ... cell membranes and cosinophil and endocrine cell ...
... In Vitro Osteogenesis Assay Kit contains all ... a mature osteoblastic lineage, as determined by ... provides all the necessary reagents and a ... plate reader. This product is useful for ...
... standard for automated bioresearch: Developed for ... • Based on decades of experience ... designed for bioresearch • Holographic gratings ... reliability and ease-of-use • Pulsed Xenon ...
... MSn data, the patent-pending Formula Predictor ... of fragmentation, isotope pattern verification, and ... determine the correct formula for unknown ... deducing empirical formulae from mass spec ...
Biology Products: