Navigation Links
PeriCor Therapeutics Announces Closing of Licensing Agreement for Acadesine with Schering-Plough Corporation
Date:8/20/2007

cardioprotective activity. Last year, a landmark study of this novel cardioprotective agent demonstrated the drug's ability to prolong long-term survival in those patients who suffer heart attacks following heart bypass surgery. Among patients who underwent CABG surgery and suffered post-reperfusion myocardial infarction (MI), mortality after two years was reduced by 77% with acadesine treatment. (p=0.006) (JACC 2006: 48:206-14). The principal benefit, which was observed in the first 30 days following MI, was sustained over the two-year period. The incidence of adverse events was similar in the acadesine and placebo groups, with the exception of a transient increase in serum uric acid among acadesine-treated patients and a higher incidence of heart failure in placebo-treated patients.

Adenosine-Mediated Cardioprotection

Adenosine regulation by acadesine provides highly site- and event-specific amplification of adenosine-mediated cardioprotection while exhibiting a remarkable safety profile in more than 2,000 patients who have received the drug in controlled clinical trials. Adenosine targets a broad-spectrum of the pathophysiology of ischemia/reperfusion injury that involves an even broader range of chemical mediators and cell types than was recognized only ten years ago. Adenosine has been shown to be a powerful mediator of ischemic preconditioning, the most potent approach to reducing infarct size in ischemia/reperfusion injury in animal studies.

"Acadesine represents the first of an entirely new class of cardioprotective agents that harness and enhance the cardioprotective activity of endogenous adenosine," said Robert L. Engler, M.D., one of the original discoverers of the cardioprotective effects of adenosine regulating agents (ARAs). "As such, we are optimistic that acadesine may become the first clinically available 'preconditioning mimetic' agent." Mr. Stover noted, "The closing of this licensing transaction will enable PeriCor to move ahe
'/>"/>

SOURCE PeriCor Therapeutics, Inc.

Copyright©2007 PR Newswire.

Page: 1 2 3

Related biology technology :

1. Canadian firm buys Proventiv Therapeutics, makes ex-Bone Care exec CEO
2. Speaker announces business members of IT Task Force
3. Doyle announces technology tax credits for Berbee
4. Doyle announces new energy, global warming policies
5. Doyle announces $80M renewable energy strategy
6. GE announces first installation of Discovery VCT
7. UWM announces winners of RGI awards
8. Third Wave announces two senior management appointments
9. Mirus announces new method for making antibodies
10. Merge announces sofware updates, upcoming acquisition
11. Small Tree announces ethernet solution for Apple Xserv G5
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... October 20, 2014 Convey Computer ... a team from Iowa State University won first place ... Using a Convey HC-2ex, the team’s solution achieved the ... faster than the second place finisher. , Experts from ... upon the month long challenge, using a variety of ...
(Date:10/20/2014)... Oct. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or ... brings Q3 orders to $5.8 million and provides a good start ... North America and one in the ... new projects at record levels," said Peter Bruijns , President ... the end of Q3 than they have been for any complete ...
(Date:10/20/2014)... , Oct. 20, 2014  GenVec, Inc. (NASDAQ: ... P. Horovitz , Ph.D., from its board of directors effective ... in August 2003, and served as its chairman from June ... on the Nominating and Corporate Governance and Audit Committees of ... more than a decade of dedicated service to GenVec, and ...
(Date:10/20/2014)... OncLive® is pleased ... at Thomas Jefferson University has joined its Strategic ... Alliance Partnership program, the Sidney Kimmel Cancer Center ... awareness of the Center’s cutting-edge research programs, comprehensive ... and other health care professionals from the Sidney ...
Breaking Biology Technology:Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Zola P. Horovitz To Retire From GenVec Board 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3
... peroxide is one of the world,s most versatile and ... O 2 is commonly used as a bleach, ... however, says Christopher J. Kiely, hydrogen peroxide has eluded ... direct, efficient and environmentally friendly means of producing it. ...
... BRISBANE, Calif., Feb. 19 InterMune, Inc. (Nasdaq: ... 7,491,794, a composition of matter patent which covers the ITMN-191 ... October 13, 2024. ITMN-191 is an inhibitor of the ... Chief Executive Officer and President of InterMune, said, "We are ...
... Inc. (Nasdaq: HGSI ) today announced that ... financial results for the year ended December 31, 2008. ... Thursday, February 26, 2009, after the capital markets close.(Logo: ... hosted by senior management and will be held on ...
Cached Biology Technology:Gold-palladium nanoparticles achieve greener, smarter production of hydrogen peroxide 2Gold-palladium nanoparticles achieve greener, smarter production of hydrogen peroxide 3Gold-palladium nanoparticles achieve greener, smarter production of hydrogen peroxide 4InterMune Announces Issuance of U.S. Patent for ITMN-191 2InterMune Announces Issuance of U.S. Patent for ITMN-191 3Human Genome Sciences to Sponsor Conference Call to Discuss Full Year 2008 Financial Results 2
(Date:10/16/2014)... Northridge, Calif. (October 16, 2014) – Post-menopausal women ... effect on hormone levels or genital bleeding, after ... of an investigational fermented soy germ-based nutritional supplement ... according to a new peer-reviewed pilot study reported ... Society (NAMS) annual scientific meeting. , "These ...
(Date:10/15/2014)... our ability to assess the pandemic risk from strains ... we must not allow ourselves to become complacent that ... international consortium of scientists. , Influenza pandemics arise when ... yet to develop widespread immunity – spreads in the ... the past 100 years, the worst of which – ...
(Date:10/15/2014)... and to an unexpected extent. The outbreak does not ... virus shows a new disease dynamic in regions, where ... the German National Academy of Sciences Leopoldina, acatech – ... Union of the German Academies of Sciences and Humanities ... , In the statement the academies call for the ...
Breaking Biology News(10 mins):S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5
... from Philadelphia and Norway has determined the structure of an ... and is made at elevated levels in numerous forms of ... , led by researchers at The Wistar Institute, depicts the ... called NatA. Their findings, they believe, will allow them ...
... 2, 2013) In a new observational study published ... looked at the association of grape consumption, in the ... and 100% grape juice with the diet quality ... and adults. Their findings suggest that, among adults and ...
... Within sight of the Trans-Canada Highway, a team of ... set out on foot for a nearby site where they,d ... In the short distance they walked, with Canada,s ... in the Bow River bottomland, the team spotted five grizzly ...
Cached Biology News:Wistar scientists decipher structure of NatA, an enzyme complex that modifies most human proteins 2Grape consumption associated with healthier eating patterns in US children and adults 2Montana State University researchers highlight bears' use of Banff highway crossings 2Montana State University researchers highlight bears' use of Banff highway crossings 3Montana State University researchers highlight bears' use of Banff highway crossings 4
... modified nucleotide structure called a ?cap? ... most naturally-occurring eukaryotic mRNAs and many ... for a portion of the GTP ... reaction results in the synthesis of ...
... A modified nucleotide structure called a ... of most naturally-occurring eukaryotic mRNAs and ... Analog for a portion of the ... transcription reaction results in the synthesis ...
... A modified nucleotide structure called ... 5?-end of most naturally-occurring eukaryotic mRNAs ... Cap Analog for a portion of ... vitro transcription reaction results in the ...
... Orbital Shakers have the durability ... stacked 3-high, and the uniformity ... "soft shake" applications. Heavily ... systems, our stackers are designed ...
Biology Products: