Peregrine Pharmaceuticals Reports Studies Published in 'Science' Highlight Key Role of Phosphatidylserine (PS) in Viral ...(immune systemrecognition and destruction...)

In a separate Science Perspective article discussing the studies(3), the commentators note that the essential role of PS may not be limited to vaccinia infections, but may also play a role in HIV infection. Vaccinia and HIV are both enveloped viruses, and as the articles discuss, PS becomes exposed on the surface of enveloped viruses and the cells they infect. This is consistent with findings by Peregrine researchers showing that its anti-PS antibodies bind to every enveloped virus tested. The company's anti-PS antibodies have also demonstrated promising anti-viral activity against a number of enveloped viruses in preclinical tests, as well as in clinical trials in patients infected with HCV, which is an enveloped virus. In addition to the ongoing clinical trial in HCV patients co-infected with HIV, Peregrine's anti-PS antibodies are currently being studied in animal models of HIV.

Peregrine's anti-PS technology is exclusively licensed from the University of Texas Southwestern Medical Center at Dallas, where Dr. Philip Thorpe has been a pioneer in investigating the role of anti-phosphatidylserine therapies in viral infections and cancer for more than a decade.

"It is gratifying to see the growing momentum of scientific interest and inquiry in the unique role of PS in immune system function and dysfunction," said Dr. Thorpe. "Our extensive work in the potential of anti-PS therapies for treating virus infections and cancer has been predicated on the same types of mechanisms that are elucidated and discussed in these first-rate studies, and we welcome the independent corroboration and additional insights that this new research is providing to the field."

About Peregrine's Anti-PS Antibody Bavituximab

Peregrine's clinical stage monoclonal antibody bavituximab is in
'/>"/>