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Peregrine Completes Patient Enrollment in Cotara(R) Dose Confirmation and Dosimetry Brain Cancer Trial
Date:12/2/2009

TUSTIN, Calif., Dec. 2 /PRNewswire-FirstCall/ -- Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM) today reported completion of patient enrollment in a dose confirmation and dosimetry trial of Cotara® in patients with relapsed glioblastoma multiforme (GBM), the deadliest form of brain cancer. Cotara is a targeted monoclonal antibody linked to a radioisotope being developed as a potential new treatment for GBM. Cotara specifically targets cells at the center of brain tumors, so its radioactive payload is able to kill cancer cells while leaving healthy tissue largely unaffected. Cotara is also being tested in a Phase II clinical trial in patients with recurrent GBM.

In the ongoing dose confirmation and dosimetry study, patients received a single treatment of Cotara and were evaluated for specificity of drug localization to the tumor, as well as for progression-free survival and overall patient survival. Initial data from the trial show that all of the patients in the first two completed study cohorts have survived longer than the expected six-month median survival time for GBM patients and they confirm Cotara's targeting capabilities, indicating that it delivers more than 300-fold higher radiation levels to the tumor than to normal organs.

"Completion of patient enrollment in this study is a significant regulatory milestone for Cotara, representing an important component of the Cotara clinical development program," said Dr. Robert Garnick, head of regulatory affairs at Peregrine. "With enrollment in this trial now completed, we are turning our attention to expanding the ongoing Cotara Phase II GBM trial to further advance the program. Given the encouraging data seen to date in the Cotara brain cancer trials, we plan to explore available clinical and regulatory options for expediting Cotara development."


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SOURCE Peregrine Pharmaceuticals, Inc.
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