Navigation Links
Peptimmune to Collaborate on Dengue Virus Vaccine and Point-Of-Care Diagnostic With Two DOD Biomedical Research Facilities
Date:9/24/2009

CAMBRIDGE, Mass., Sept. 24 /PRNewswire/ -- Peptimmune, Inc. ("Peptimmune"), a privately held biotechnology company announced today that it has formed a research and development collaboration with the Walter Reed Army Institute of Research (WRAIR) and the Naval Medical Research Center (NMRC), Silver Spring, MD to evaluate the Company's proprietary DEEP(TM) peptide copolymer technology for the potential development of dengue vaccines and point-of-care diagnostics.

After more than 70 years of work a safe and effective dengue virus (DENV) vaccine remains an elusive goal. Previous vaccine candidates have shown unpredictable interactions among the four DENVs often leading to unwanted reactogenicity and low seroconversion rates. Rapid, serotype-specific diagnosis of DENV infection is an equally perplexing problem. Existing tests are often confounded after secondary dengue infection due to extensive serotype cross-reactivity, and the rapid evolution of DENV strains in many regions of the world.

Peptimmune has developed a novel peptide copolymer-based technology, DEEP (Directed Expansion of Epitope Permutations), which may overcome these problems. The goal of this research and development collaboration is to evaluate the DEEP technology to potentially design DENV-specific peptide copolymers containing (1) potentially protective T-cell epitopes, (2) serotype-specific diagnostic epitopes, and (3) protective B-cell epitopes for generating immuno-prophylactic antibodies. WRAIR/NMRC investigators bring to the effort their expert knowledge of DENV. Evaluation of the diagnostics and vaccines generated in the collaboration will be performed in laboratory models at WRAIR/NMRC.

The results of this collaborative effort have the potential to provide important insights into dengue immunity and advance the development of a protective vaccine.

About DEEP

DEEP is a peptide copolymer technology that is able to target the hypervariable regions of viruses generating antigenic diversity to anticipate evolutionary changes and overcome immune-dominance, while preserving antigenic specificity by incorporating any desired B- or T-cell epitope. DEEP takes advantage of Peptimmune's know-how in the solid-phase manufacturing of complex peptide mixtures. The technology combines the epitope specificity of a fixed-sequence peptide with the randomness of a broadly immune-interactive copolymer.

About Peptimmune (www.peptimmune.com)

Peptimmune is a clinical stage biotechnology company developing peptide and peptide-copolymer therapeutics for the treatment of CNS and Autoimmune disorders. These therapies target MHC Class II molecules and modulating immune responses. Founded in 2002 and located in Cambridge, MA USA, the Company is led by an experienced management team and exploits its proprietary DEEP(TM) Technology to design peptides and peptide mixtures for use as novel vaccines, ligands for antibodies, and theranostics for autoimmune disorders.


'/>"/>
SOURCE Peptimmune, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Related biology technology :

1. Peptimmune Completes Phase Ib Study of PI-2301 in Multiple Sclerosis Patients, and Presentation at ECTRIMS 2009
2. Peptimmune Presentations at Upcoming Events
3. Peptimmune Presentation at Upcoming World Congress on Treatment and Research in Multiple Sclerosis
4. Peptimmune Announces First Close of Series D Private Financing
5. Cardea Technology Inc and Optasia Medical Ltd Announce Plans to Collaborate to Optimize Their Vertebral Fracture Assessment Tools
6. Two Lehigh Valley Healthcare Leaders Collaborate to Deliver Safer, High-Quality Care to the Community
7. Cellworks Group and ISP Personal Care Collaborate to Demonstrate Effectiveness of Proteomics-Based Computer Modeling of Skin Biology
8. SENOMYX AND FIRMENICH TO COLLABORATE ON DISCOVERY, DEVELOPMENT AND WORLDWIDE COMMERCIALIZATION OF NOVEL SWEET ENHANCERS
9. Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO)
10. PacificGMP and USC to Collaborate on Recombinant Protein Development and Manufacturing for Phase 1 Clinical Trial
11. DuPont and Arzeda Collaborate to Develop Improved Crops to Increase Productivity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... -- Cousins Properties (NYSE: CUZ ) announced today ... signed a 10-year, approximately 125,000 square-foot lease at Corporate Center, ... the Westshore submarket of Tampa, FL. ... Corporate Center for their new location in Tampa ... executive officer of Cousins Properties. "Amgen is a cutting-edge global ...
(Date:3/27/2017)... Infectex Ltd., a Russian portfolio company of Maxwell Biotech Venture Fund (MBVF), ... the standard drug therapy regimen in patients with multidrug-resistant pulmonary tuberculosis (MDR-TB). SQ109 is ... ) and the US National Institutes of Health. ... ... ...
(Date:3/27/2017)... , March 27, 2017  Perthera,s Chief Bioinformatics Officer ... Subha Madhavan , Ph.D., will be speaking at ... Panels. On Monday, March 27, 2017, she will be ... More Usable for Research and Care" (from 10:30 a.m. ... 2017, she will be a participant in the "Making ...
(Date:3/27/2017)... ... ... PMG Research is pleased to announce its participation in the 2nd ... Boston on April 3-4, 2017. The CTC conference focuses on how the industry is ... closer to the patient. Clinical Trial Collaborations also will present an inaugural conference on ...
Breaking Biology Technology:
(Date:2/28/2017)... 28, 2017   Acuant , a leading provider ... significant enhancements to new and core technologies building upon ... include mobile and desktop Acuant FRM TM facial ... a real time manual review of identity documents by ... the fastest and most accurate capture software to streamline ...
(Date:2/27/2017)... WASHINGTON , Feb. 27, 2017   Strategic ... fund, today announced it has led a $3.5 million investment ... collaboration platform. Strategic Cyber Ventures is DC based and ... and Hank Thomas . Ron Gula , ... Tech Ventures, also participated in this series A round ...
(Date:2/22/2017)... With the biometrics market to exceed ... technologies that innovative and agile startups must incorporate ... the changing competitive landscape: multifactor authentication (MFA), point-of-sale ... "Companies can no longer afford to cut ... Dimitrios Pavlakis , Industry Analyst at ABI Research. ...
Breaking Biology News(10 mins):