Navigation Links
Peptimmune to Collaborate on Dengue Virus Vaccine and Point-Of-Care Diagnostic With Two DOD Biomedical Research Facilities
Date:9/24/2009

CAMBRIDGE, Mass., Sept. 24 /PRNewswire/ -- Peptimmune, Inc. ("Peptimmune"), a privately held biotechnology company announced today that it has formed a research and development collaboration with the Walter Reed Army Institute of Research (WRAIR) and the Naval Medical Research Center (NMRC), Silver Spring, MD to evaluate the Company's proprietary DEEP(TM) peptide copolymer technology for the potential development of dengue vaccines and point-of-care diagnostics.

After more than 70 years of work a safe and effective dengue virus (DENV) vaccine remains an elusive goal. Previous vaccine candidates have shown unpredictable interactions among the four DENVs often leading to unwanted reactogenicity and low seroconversion rates. Rapid, serotype-specific diagnosis of DENV infection is an equally perplexing problem. Existing tests are often confounded after secondary dengue infection due to extensive serotype cross-reactivity, and the rapid evolution of DENV strains in many regions of the world.

Peptimmune has developed a novel peptide copolymer-based technology, DEEP (Directed Expansion of Epitope Permutations), which may overcome these problems. The goal of this research and development collaboration is to evaluate the DEEP technology to potentially design DENV-specific peptide copolymers containing (1) potentially protective T-cell epitopes, (2) serotype-specific diagnostic epitopes, and (3) protective B-cell epitopes for generating immuno-prophylactic antibodies. WRAIR/NMRC investigators bring to the effort their expert knowledge of DENV. Evaluation of the diagnostics and vaccines generated in the collaboration will be performed in laboratory models at WRAIR/NMRC.

The results of this collaborative effort have the potential to provide important insights into dengue immunity and advance the development of a protective vaccine.

About DEEP

DEEP is a peptide copolymer technology that is able to target the hypervariable regions of viruses generating antigenic diversity to anticipate evolutionary changes and overcome immune-dominance, while preserving antigenic specificity by incorporating any desired B- or T-cell epitope. DEEP takes advantage of Peptimmune's know-how in the solid-phase manufacturing of complex peptide mixtures. The technology combines the epitope specificity of a fixed-sequence peptide with the randomness of a broadly immune-interactive copolymer.

About Peptimmune (www.peptimmune.com)

Peptimmune is a clinical stage biotechnology company developing peptide and peptide-copolymer therapeutics for the treatment of CNS and Autoimmune disorders. These therapies target MHC Class II molecules and modulating immune responses. Founded in 2002 and located in Cambridge, MA USA, the Company is led by an experienced management team and exploits its proprietary DEEP(TM) Technology to design peptides and peptide mixtures for use as novel vaccines, ligands for antibodies, and theranostics for autoimmune disorders.


'/>"/>
SOURCE Peptimmune, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Related biology technology :

1. Peptimmune Completes Phase Ib Study of PI-2301 in Multiple Sclerosis Patients, and Presentation at ECTRIMS 2009
2. Peptimmune Presentations at Upcoming Events
3. Peptimmune Presentation at Upcoming World Congress on Treatment and Research in Multiple Sclerosis
4. Peptimmune Announces First Close of Series D Private Financing
5. Cardea Technology Inc and Optasia Medical Ltd Announce Plans to Collaborate to Optimize Their Vertebral Fracture Assessment Tools
6. Two Lehigh Valley Healthcare Leaders Collaborate to Deliver Safer, High-Quality Care to the Community
7. Cellworks Group and ISP Personal Care Collaborate to Demonstrate Effectiveness of Proteomics-Based Computer Modeling of Skin Biology
8. SENOMYX AND FIRMENICH TO COLLABORATE ON DISCOVERY, DEVELOPMENT AND WORLDWIDE COMMERCIALIZATION OF NOVEL SWEET ENHANCERS
9. Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO)
10. PacificGMP and USC to Collaborate on Recombinant Protein Development and Manufacturing for Phase 1 Clinical Trial
11. DuPont and Arzeda Collaborate to Develop Improved Crops to Increase Productivity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, into ... for over 35 years, is proud to add Target to its list of ...
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
(Date:6/23/2016)... -- Houston Methodist Willowbrook Hospital has signed a ... serve as their official health care provider. As ... provide sponsorship support, athletic training services, and most ... athletes and families. "We are excited ... to bring Houston Methodist quality services and programs ...
(Date:6/23/2016)... June 23, 2016  The Prostate Cancer Foundation (PCF) is pleased ... and faster cures for prostate cancer. Members of the Class of 2016 were ... Read More About the Class of 2016 PCF Young ... ... ...
Breaking Biology Technology:
(Date:6/2/2016)... June 2, 2016   The Weather Company , an ... Ads, an industry-first capability in which consumers will be able ... to ask questions via voice or text and receive relevant ... Marketers have long sought an advertising solution ... can be personal, relevant and valuable; and can scale across ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
(Date:5/3/2016)... Lithuania , May 3, 2016  Neurotechnology, ... released the MegaMatcher Automated Biometric Identification System ... of large-scale multi-biometric projects. MegaMatcher ABIS can process ... accuracy using any combination of fingerprint, face or ... MegaMatcher SDK and MegaMatcher Accelerator ...
Breaking Biology News(10 mins):