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Penn researchers successfully alleviate pulmonary inflammation with targeted drug delivery
Date:7/14/2014

The team used a nanogel, a specialized nanocarrier, for drug delivery made up of two moleculesdextran (a sugar) and lysozyme (a protein)which mesh into a spaghetti-like ball that can fill with water to expand and contract. A specific lung-targeting molecule is attached to the carrier's surface and the steriod, dexamethasone, an anti-inflammatory, is loaded into the nanogel, which then binds to lung endothelial cells lining the inside wall of the blood vessels where it rapidly delivers the drug.

"This molecule on the surface of the nanocarrier has specialized preference for the lung to enhance localized and targeted drug delivery," says Eckmann.

The team next plans to try the therapy in a cohort of patients at the Hospital of the University of Pennsylvania.


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Contact: Lee-Ann Donegan
leeann.donegan@uphs.upenn.edu
215-349-5660
University of Pennsylvania School of Medicine
Source:Eurekalert  

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Penn researchers successfully alleviate pulmonary inflammation with targeted drug delivery
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