Navigation Links
Penn-led collaboration mimics library of bio-membranes for use in nanomedicine, drug delivery
Date:5/20/2010

stability and mechanical strength obtainable from polymersomes, vesicles made from block copolymers, with the biological function of stabilized phospholipid liposomes," said Percec, the P. Roy Vagelos Chair and Professor of Chemistry at Penn, "but with superior uniformity of size, ease of formation and chemical functionalization."

"These materials show special promise because their membranes are the thickness of natural bilayer membranes, but they have superior and tunable materials properties," said Hammer, the Alfred G. and Meta A. Ennis Professor of Bioengineering at Penn. "Because of their membrane thickness, it will be more straightforward to incorporate biological components into the vesicle membranes, such as receptors and channels."

"No other single class of molecules including block copolymers and lipids is known to assemble in water into such a diversity of supramolecular structures," said Bates, the Regents Professor and Head of the Chemical Engineering and Materials Science Department at the University of Minnesota.

Self-assembled nanostructures, obtained from natural and synthetic amphiphiles, increasingly serve as mimics of biological membranes and enable the targeted delivery of drugs, nucleic acids, proteins, gene therapy and imaging agents for diagnostic medicine. The challenge for researchers is creating these precise molecular arrangements that combine to function as safe biological carriers while carrying payload within.

Janus dendrimer assemblies offer several advantages to other competing technologies for nano-particle delivery. Liposomes are mimics of cell membranes assembled from natural phospholipids or from synthetic amphiphiles, including polymersomes. But, liposomes are not stable, even at room temperature, and vary widely in size, requiring tedious stabilization and fractionation for all practical applications. Polymersomes, on the other hand, are stable but polydisperse, and most of them are not
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Educating the Marketplace Through Collaborations with Patient Advocacy Groups
2. Elekta / Mitsubishi Electric Collaboration Helps Japans Gunma University Heavy Ion Medical Center Launch Advanced Carbon Ion Therapy for Treating Cancer
3. Cheaper drugs, vaccines forecast as collaborations grow between developing countries biotech firms
4. iCyt Unveils New Flow Cytometry Products in Collaboration with Sony at CYTO2010
5. Boehringer Ingelheim and Micromet Announce Global Collaboration for Multiple Myeloma BiTE Antibody
6. S*BIO and Onyx Pharmaceuticals Announce Expanded Development Collaboration for JAK2 Inhibitors
7. TB Alliance and AstraZeneca Form Research Collaboration to Fight Tuberculosis
8. Goodwin Biotechnology Inc. and Hyprocell LLC Announce Collaboration
9. Australia Substantially Increases Research Collaboration with China, According to Thomson Reuters Study
10. Reportlinker Adds The Future of Nutrigenomics: New opportunities in personalized nutrition and food-pharma collaboration
11. Lung Rx and ImmuneWorks Announce Collaboration in Idiopathic Pulmonary Fibrosis and Primary Graft Dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn-led collaboration mimics library of bio-membranes for use in nanomedicine, drug delivery
(Date:12/19/2014)... 19, 2014  Roche (SIX: RO, ROG; OTCQX: RHHBY) ... (Bina), a privately held company based in ... provides a big data platform for centralized management ... Bina,s proprietary on-market Genomic Management Solution, Bina-GMS 1 ... perform fast and scalable analyses to maximize the ...
(Date:12/19/2014)... Mass. , Dec. 19, 2014 Decision ... market will grow at a 12 percent compound annual ... result of the aging population and the increasing adoption ... Latin America will also spur demand for ... of dental implant and periodontal treatments. Other ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 ... nation’s leading specialty pharmacies, has an expanded team ... clinical pharmacy consultants for prescriber offices in their ... , “We have a variety of Regional ... example, those specializing in hepatitis C help prescribers ...
(Date:12/19/2014)... LayerBio is an MIT spin-off developing ... The National Eye Institute (NEI) at the National Institutes ... SBIR grant to develop a drug-eluting intraocular lens (IOL) ... cause of vision loss in people over age 40 ... Dr. Ken Mandell, LayerBio’s Founder and CEO, "There is ...
Breaking Biology Technology:Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2
... at 7:00 p.m. Eastern Time in Conjunction with ... Leading Cardiothoracic Surgeons Conference - ... (Nasdaq: CRDC ) and Intuitive,Surgical, Inc. (Nasdaq: ISRG ... topic of "Advanced Techniques and Technologies in Robotic,Coronary Revascularization and ...
... 18 ,ThromboGenics NV (Euronext Brussels: THR) and ... announce today that they,have received approval from ... Phase I clinical trial of the novel ... that targets the angiogenic factor PlGF,(placental growth ...
... Jan. 17, 2008 Scientific studies on climate change, ... awarded more than 145 million processing hours on supercomputers ... Energys Innovative and Novel Computational Impact on Theory and ... from industry, academia and government research facilities receive access ...
Cached Biology Technology:Cardica and Intuitive Surgical to Host Educational Symposium on 'Advanced Techniques and Technologies in Robotic Coronary Revascularization and Mitral Valve Repair' 2Cardica and Intuitive Surgical to Host Educational Symposium on 'Advanced Techniques and Technologies in Robotic Coronary Revascularization and Mitral Valve Repair' 3Cardica and Intuitive Surgical to Host Educational Symposium on 'Advanced Techniques and Technologies in Robotic Coronary Revascularization and Mitral Valve Repair' 4Cardica and Intuitive Surgical to Host Educational Symposium on 'Advanced Techniques and Technologies in Robotic Coronary Revascularization and Mitral Valve Repair' 5ThromboGenics and BioInvent Receive Approval to Begin Clinical Trials of TB-403 for the Treatment of Cancer 2ThromboGenics and BioInvent Receive Approval to Begin Clinical Trials of TB-403 for the Treatment of Cancer 3ThromboGenics and BioInvent Receive Approval to Begin Clinical Trials of TB-403 for the Treatment of Cancer 4ThromboGenics and BioInvent Receive Approval to Begin Clinical Trials of TB-403 for the Treatment of Cancer 5Oak Ridge leads DOE INCITE effort in 2008 2Oak Ridge leads DOE INCITE effort in 2008 3Oak Ridge leads DOE INCITE effort in 2008 4
(Date:12/19/2014)... 18, 2014   LaunchKey , the first decentralized ... and Internet of Things era, today announced the close ... round was led by Metamorphic Ventures with participation from ... VegasTechFund, and others.  LaunchKey has raised $4 million to ... its team and bring LaunchKey to market in 2015. ...
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM ... Clinical Practices (GCP) audit to confirm its adherence ... regulations. This accomplishment enables HITLAB to conduct regulated ... the highest principles for patient safety and research ... global healthcare access, quality, and delivery with innovative ...
(Date:12/17/2014)... DENVER , Dec. 16, 2014  Automation ... is this more evident than at international borders. ... secure document scanners have allowed veteran travelers to ... Automated Passport Control (APC) Kiosks at an increasing ... the globe. According to ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... a common vaginal infection linked to preterm birth appears ... to a University of Pittsburgh School of Medicine study ... Infectious Diseases Society for Obstetrics and Gynecology in Boston. ... risk of preterm birth goes up, said Hyagriv Simhan, ...
... -- The striking differences between humans and chimps arent so much ... but in the way those genes are used, according to new ... the same set of notes being played in very different ways. ... and other primates those involving brains and diet gene ...
... motor in cochlea hair cells dominates the process of ... the cilia atop those cells dominates the response in ... cells in the inner ear amplify sound in mammals ... bouncing cell bodies rather than vibrating, hair-like cilia, according ...
Cached Biology News:Risk of common vaginal infection linked to preterm birth appears higher for blacks 2Gene regulation, not just genes, is what sets humans apart 2Gene regulation, not just genes, is what sets humans apart 3St. Jude study solves mystery of mammalian ears 2St. Jude study solves mystery of mammalian ears 3
... / 3T3 cells were cultured in DMEM with ... phase of growth. In order to keep ... fixed in acetone-methanol. The cells are arrayed ... with each wells surface specifically treated to enhance ...
Miscellaneous: Versatile stain for staining RNA (bluish-purple), DNA (blue), proteins (red) and acid polysaccharides Assay: ~ 95 % Suitab tst: differential staining of nucleic acids and prote...
... MasterAmp™ 10X PCR Enhancer (with betaine) ... improved sensitivity and specificity for amplification ... PCR Enhancer in PCR eliminates the ... increases enzyme?s thermal stability, suppresses pauses ...
... with 96- or 384-well PCR plates Dimples on ... on 96-tube plates End tabs on Thermo-Mat™ 384 ... Efficient sealing is achieved with either Thermo-Mat™ 96 ... clip-down hot lid thermal cyclers Fully autoclavable ...
Biology Products: