Navigation Links
Penn-led collaboration mimics library of bio-membranes for use in nanomedicine, drug delivery
Date:5/20/2010

stability and mechanical strength obtainable from polymersomes, vesicles made from block copolymers, with the biological function of stabilized phospholipid liposomes," said Percec, the P. Roy Vagelos Chair and Professor of Chemistry at Penn, "but with superior uniformity of size, ease of formation and chemical functionalization."

"These materials show special promise because their membranes are the thickness of natural bilayer membranes, but they have superior and tunable materials properties," said Hammer, the Alfred G. and Meta A. Ennis Professor of Bioengineering at Penn. "Because of their membrane thickness, it will be more straightforward to incorporate biological components into the vesicle membranes, such as receptors and channels."

"No other single class of molecules including block copolymers and lipids is known to assemble in water into such a diversity of supramolecular structures," said Bates, the Regents Professor and Head of the Chemical Engineering and Materials Science Department at the University of Minnesota.

Self-assembled nanostructures, obtained from natural and synthetic amphiphiles, increasingly serve as mimics of biological membranes and enable the targeted delivery of drugs, nucleic acids, proteins, gene therapy and imaging agents for diagnostic medicine. The challenge for researchers is creating these precise molecular arrangements that combine to function as safe biological carriers while carrying payload within.

Janus dendrimer assemblies offer several advantages to other competing technologies for nano-particle delivery. Liposomes are mimics of cell membranes assembled from natural phospholipids or from synthetic amphiphiles, including polymersomes. But, liposomes are not stable, even at room temperature, and vary widely in size, requiring tedious stabilization and fractionation for all practical applications. Polymersomes, on the other hand, are stable but polydisperse, and most of them are not
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Educating the Marketplace Through Collaborations with Patient Advocacy Groups
2. Elekta / Mitsubishi Electric Collaboration Helps Japans Gunma University Heavy Ion Medical Center Launch Advanced Carbon Ion Therapy for Treating Cancer
3. Cheaper drugs, vaccines forecast as collaborations grow between developing countries biotech firms
4. iCyt Unveils New Flow Cytometry Products in Collaboration with Sony at CYTO2010
5. Boehringer Ingelheim and Micromet Announce Global Collaboration for Multiple Myeloma BiTE Antibody
6. S*BIO and Onyx Pharmaceuticals Announce Expanded Development Collaboration for JAK2 Inhibitors
7. TB Alliance and AstraZeneca Form Research Collaboration to Fight Tuberculosis
8. Goodwin Biotechnology Inc. and Hyprocell LLC Announce Collaboration
9. Australia Substantially Increases Research Collaboration with China, According to Thomson Reuters Study
10. Reportlinker Adds The Future of Nutrigenomics: New opportunities in personalized nutrition and food-pharma collaboration
11. Lung Rx and ImmuneWorks Announce Collaboration in Idiopathic Pulmonary Fibrosis and Primary Graft Dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn-led collaboration mimics library of bio-membranes for use in nanomedicine, drug delivery
(Date:1/15/2014)... (PRWEB) January 15, 2014 Cynvenio, a ... management through the genomic analysis of tumor cells in ... Finder™, a web-based cancer decision support application powered by ... with Cynvenio’s ClearID™ genomic test, Therapy Finder will provide ...
(Date:1/15/2014)... 15, 2014 ­ RedBrick Health , a fast-growing ... today announces that EmblemHealth , the ... is now providing the RedBrick Compass health assessment, combined ... all of its members. EmblemHealth is among the first ...
(Date:1/15/2014)... England , January 15, 2014 A ... win races on the Formula 1 track could help to ... McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based in ... by healthcare provider Simplyhealth. Telemetry technology, which is ...
(Date:1/15/2014)... January 15, 2014 Two champions of ... their sponsorship of an annual competition for middle and ... access to, innovative STEM study. The competition presents students ... Tests of Engineering Aptitude, Mathematics, and Sciences is ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5
... Toronto Stock Exchange Symbol: MS, EDMONTON, Sept. 19 /PRNewswire-FirstCall/ ... treatment of multiple sclerosis (MS), today,announced that Mr. Kevin Giese, ... Conference in New York., WHEN: ... Grand Hyatt New York, New York, ...
... Keck Graduate Institute,(KGI) today announced that it ... learn the latest developments in mammalian cell culture,from ... undergone explosive growth over the,last 25 years," said ... Rathmann,Professor and director of the Amgen Bioprocessing Center ...
... Inc. (OTC Bulletin Board: YGYB; "Yongye" or the ... acid based,nutrients for plants and animals in the ... shareholders from the Company,s CEO and Chairman of,the ... events and plans,for the future., Dear Shareholders:, ...
Cached Biology Technology:BioMS Medical to present at UBS Global Life Sciences Conference 2KGI Offers Mammalian Cell Culture Program for Biotech Industry Professionals 2Letter to Shareholders from the CEO and Chairman of the Board of Yongye Biotechnology, Inc. 2Letter to Shareholders from the CEO and Chairman of the Board of Yongye Biotechnology, Inc. 3Letter to Shareholders from the CEO and Chairman of the Board of Yongye Biotechnology, Inc. 4Letter to Shareholders from the CEO and Chairman of the Board of Yongye Biotechnology, Inc. 5Letter to Shareholders from the CEO and Chairman of the Board of Yongye Biotechnology, Inc. 6
(Date:4/17/2014)... Singh Thursday as a "Champion of Change" for ... in the residential, commercial and industrial sectors. , ... and Computer Engineering and director of Clemson,s Center ... leading the charge across the country to create ... driving policy changes at the local level to ...
(Date:4/17/2014)... the Amazon help create tinderbox conditions for wildfires ... forest loss during drought years, according to a ... in the Amazon could reach a "tipping point" ... to large-scale loss of trees, making recovery more ... Penn State. , "We documented one of the ...
(Date:4/17/2014)... The recent Yokahama IPCC meeting painted a stark warning ... which has a greenhouse effect 32 times that ... have shown that humic substances act as fully regenerable ... methane are held in wetlands instead of being released ... this system is disrupted it may enter into a ...
Breaking Biology News(10 mins):White House honors Clemson professor as 'Champion of Change' for solar deployment 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3Methane climate change risk suggested by proof of redox cycling of humic substances 2
... EVANSTON, Ill. --- A Northwestern University research team ... could be used to deliver chemotherapy drugs locally ... removed. The flexible microfilm device, which ... be customized easily into different shapes, has the ...
... planning of the preparatory activities for a new tentative ... satellite. On 7 September, preparatory activities for the ... Russia were stopped by Eurockot due to an anomaly ... and navigation subsystem of the launcher,s Upper Stage Breeze ...
... reveal an electromagnetic marker that predicts a patient,s ... "Such biomarkers that identify who will benefit ... minimize trial-and-error prescribing and speed delivery of care ... Carlos Zarate, M.D., of the National Institute of ...
Cached Biology News:Nanodiamond drug device could transform cancer treatment 2Nanodiamond drug device could transform cancer treatment 3Millisecond brain signals predict response to fast-acting antidepressant 2
The imaging screen-K (Kodak), is a 35 x 43 cm storage phosphor screen that is used for the quantitation and imaging of 32P, 33P, 35S, 14C, and 3H....
The filter 695RDF55 Reflect 635 for the Molecular Imager FX is a band pass filter for Cy5 and Alexa Fluor 635 dyes....
... is a 2-color staining method for labeling ... detect apoptotic cells by flow cytometry. The ... for measuring apoptosis in cells, including positive ... performance; washing, reaction and rinsing buffers for ...
The sample holders for gels are used to hold gels in place in the multi-sample tray I, which is used with Molecular Imager FX imaging systems....
Biology Products: