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Peer-reviewed Articles Further Define Clusterin and the Role of a Clusterin Inhibitor, OGX-011, for the Treatment of Cancer
Date:3/1/2010

uary 2010; 8(1);119-130;

http://mcr.aacrjournals.org/content/8/1/119.abstract

"The links between clusterin (CLU) and NF-kB began when a two-hybrid approach identified COMMD1 as a CLU binding protein and gene profiling identified NF-kB-regulated genes coordinately altered by CLU, defining a novel mechanism whereby stress-induced increases in CLU activates the NF-kB signalosome," said Amina Zoubeidi, Assistant Professor at University of British Columbia and Vancouver Prostate Centre and lead author on the studies. "It is noteworthy that both CLU and NF-kB are activated in cancer cells by chemo- and radiation therapy and are associated with acquired anti-cancer treatment resistance, including castrate resistant prostate cancer."

"Mechanisms by which CLU exerts its pro-survival effects are becoming better elucidated, as featured in the February 15 issue of Clinical Cancer Research," said Dr. Martin Gleave, a UBC Professor and Director of the Vancouver Prostate Centre. "CLU functions
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SOURCE OncoGenex Pharmaceuticals, Inc.
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