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Peer-reviewed Articles Further Define Clusterin and the Role of a Clusterin Inhibitor, OGX-011, for the Treatment of Cancer
Date:3/1/2010

nockdown of clusterin in cancer cells with OGX-011 may enhance treatment induced apoptosis.

Researchers provide the first evidence that clusterin acts as a ubiquitin-binding protein, tagging COMMD1 and I-kB for degradation, and thereby activating the NF-kB pathway. COMMD1 and I-kB are enzymes known to regulate NF-kB, an important transcription factor responsible for regulation of immune response. Incorrect regulation of NF-kB is responsible for the production of several genes associated with cell survival, cell proliferation and anti-cancer treatment resistance. Importantly, researchers found that knockdown of clusterin in prostate cancer cells stabilizes COMMD1 and IkB thereby decreasing NF-kB activity, and consequently decreasing the production of genes associated with tumor cell survival and cancer treatment resistance.

Abstracts are available at the following AACR publication Web sites:

"Targeting the Cytoprotective Chaperon, Clusterin, for Treatment of advanced Cancer"

Amina Zoubeidi, Kim Chi, Martin Gleave


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SOURCE OncoGenex Pharmaceuticals, Inc.
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