Navigation Links
Pediatrics Study Finds Children Taking ADHD Medications Did Not Suffer More Serious Heart Problems or Cardiovascular-related Death
Date:5/16/2011

WILMINGTON, Del., May 16, 2011 /PRNewswire/ -- Children taking medication for attention deficit hyperactivity disorder suffered no more from serious heart problems or heart-related deaths than those who were not taking ADHD medications, according to a study published online today in the journal, Pediatrics.

The study, co-authored by researchers at the University of Pennsylvania and HealthCore Inc., drew data from the largest population—241,417 children and adolescents—studied to date to evaluate cardiovascular problems and death associated with pediatric ADHD medication use.  The study also includes records involving both Medicaid and commercially insured children.

Case reports of sudden death in children and adolescents treated with these drugs have led some to worry they might increase the risk of serious cardiovascular events.  Previous studies have shown conflicting results.

"We found low rates of cardiovascular events and of cardiovascular-related deaths in those children and adolescents receiving ADHD medications," said lead author Sean Hennessy, PharmD, PhD , an associate professor of epidemiology at the University of Pennsylvania School of Medicine. "For kids who will benefit from ADHD treatment, the potential risk of a cardiovascular event should not dissuade parents or caregivers from giving a child or adolescent these drugs."

The study found no significant increases in rates of sudden death, heart attack and stroke in patients taking ADHD medications compared to those not taking medications.

Researchers used data on children and adolescents from 3-17 years old from a five-state Medicaid database, as well as the HealthCore Integrated Research Database™, which contains historical and current medical and pharmacy claims data from more than 44 million enrollees in Blue Cross and Blue Shield plans across 14 states. The study identified patients ages 3-17 on ADHD medications and tracked their health records during the period they were on the medications.

"A key strength of this study is that the study data reflected experiences of children and adolescents from a wide range of demographic and economic backgrounds –those from families receiving state Medicaid benefits and those from families with private health insurance," said Gregory Daniel, PhD, MPH , HealthCore vice president of government and academic research. "We were also able to combine insurance claims data with medical records to gain much more insight into whether or not risks of severe cardiovascular events and related mortality were elevated."

The study was based on Medicaid records from 1999-2003 and HealthCore Integrated Research Database™ records from 2001-2006, well before a 2008 recommendation from the American Heart Association that an electrocardiogram be performed before starting any child or teenager on stimulant medications.  The study showed that the use of ECGs during this study period, before the 2008 recommendation, were very low.

"It is interesting to note the lower incidence of cardiac-related events, especially when you consider that very few patients from this study were screened with an ECG prior to initiating therapy," said Mark J. Cziraky, PharmD,  FAHA, HealthCore vice president of industry sponsored research.  "This would likely  have removed more patients with higher cardiac risks from the pool of patients using ADHD medications, and would have potentially lowered the rate further."

The study was funded by Shire, a manufacturer of ADHD medications.

Other authors of the study included: Hedi Schelleman, PhD; Warren B. Bilker, PhD; Brian L. Strom, MD, MPH; Stephen E. Kimmel, MD, MSCE; Craig Newcomb, MS; and James P. Guevara, MD, MPH, all from the University of Pennsylvania.

About HealthCore

HealthCore, based in Wilmington, Del., is the clinical outcomes research subsidiary of WellPoint.  HealthCore has a team of highly experienced researchers including physicians, biostatisticians, pharmacists, epidemiologists, health economists and other scientists who study the real-world safety and effectiveness of drugs, medical devices and care management interventions. HealthCore offers insight on how to best use this data and communicates these findings to health care decision-makers to support evidence-based medicine, product development decisions, safety monitoring, coverage decisions, process improvement and overall cost-effective health care. For more information, go to www.healthcore.com.


'/>"/>
SOURCE HealthCore
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. Mattel Childrens Hospital UCLA launches program in nanopediatrics
2. NewsRx Adds Pediatrics and Psychiatry Titles
3. Novel ACR Hybrid Score in Rheumatoid Arthritis Applied for the First Time to Data from the RAPID 1 Study with Cimzia® (certolizumab pegol)
4. New Phase 3 Study Results Show REMICADE® is Effective in the Treatment of Pediatric Patients With Moderate to Severe Ulcerative Colitis
5. ImmusanT Reports Positive Results from Nexvax2 Phase 1 Study in Celiac Disease
6. Study Shows Stents Are Superior to Balloons Alone for Patients With Deep Venous Thrombosis
7. Keryx Biopharmaceuticals Announces Positive Final Data from Zerenex™ Short-Term Phase 3 Study
8. Reportlinker Adds Case Study: Personalized Cancer Therapy - The era of biomarker identification and companion diagnostic co-development
9. Sequenom Announces Publication Acceptance of Manuscript From Age-related Macular Degeneration Validation Study
10. New Biomarkers Study Could Lead to Better Malaria Vaccine Design
11. Columbia engineering study links ozone hole to climate change all the way to the equator
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... DIEGO , June 24, 2016 ... more sensitively detects cancers susceptible to PARP inhibitors ... circulating tumor cells (CTCs). The new test has ... HRD-targeted therapeutics in multiple cancer types. ... targeting DNA damage response pathways, including PARP, ATM, ...
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
(Date:6/23/2016)... MONICA, Calif. , June 23, 2016  The Prostate Cancer Foundation ... pioneer increasingly precise treatments and faster cures for prostate cancer. Members of the ... institutions across 15 countries. Read More About the Class ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report ... detail how a patient who developed lymphedema after being treated for breast cancer benefitted ... change the paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
Breaking Biology Technology:
(Date:6/20/2016)... 2016 Securus Technologies, a leading provider ... public safety, investigation, corrections and monitoring announced that ... has secured the final acceptance by all three ... Access Systems (MAS) installed. Furthermore, Securus will have ... installed by October, 2016. MAS distinguishes between legitimate ...
(Date:6/7/2016)...  Syngrafii Inc. and San Antonio Credit Union ... integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution into ... result in greater convenience for SACU members and ... existing document workflow and compliance requirements. ... Highlights: ...
(Date:6/1/2016)... 2016 Favorable Government Initiatives Coupled ... Criminal Identification to Boost Global Biometrics System Market Through ... Research report, " Global Biometrics Market By Type, ... Opportunities, 2011 - 2021", the global biometrics market is ... account of growing security concerns across various end use ...
Breaking Biology News(10 mins):