Navigation Links
Parion Sciences and Kainos Medicines Sign Clinical Development Agreement for Novel Dry Mouth Treatment
Date:10/28/2008

Kainos to Fund Up to $25 Million to Advance P-552

DURHAM, N.C., Oct. 28 /PRNewswire/ -- Parion Sciences, Inc. and Kainos Medicines, Inc. today announced that they have entered into an agreement to co-develop Parion's proprietary epithelial sodium channel blocker, P-552, for the treatment of dry mouth associated with primary Sjogren's syndrome.

Under the agreement, the companies will collaborate in the clinical development of P-552. Kainos will provide funding to help advance the program through the end of Phase II clinical testing, supplying up to $25 million upon completion of all milestones. Parion will be responsible for the oversight of the clinical development program while Kainos will provide CMC (chemistry, manufacturing and controls) expertise. Upon the successful completion of the Phase II program, Parion and Kainos will determine the Phase III clinical development and commercialization of P-552.

In a Phase I/II clinical study completed in April 2008, P-552 was found to be safe and tolerable in subjects with primary Sjogren's disease. The study demonstrated promising results in several key quality of life parameters including mouth dryness, mouth comfort and ability to sleep, as assessed by Visual Analogue Scale (VAS).

"Sjogren's syndrome patients are seeking effective relief of their dry mouth. By combining the talents and expertise of two proven development teams, we believe we can accelerate the clinical development of P-552 to effectively address this unmet need," said M. Ross Johnson, Parion Chief Executive Officer. "This partnership represents the second application of our portfolio of sodium channel blockers as we continue to expand Parion's unique technology and novel compound library into other diseases requiring mucosal hydration."

"I am very pleased that Kainos and Parion will be working together on the development of P-552," said M.C. Kang, Kainos Chief Executive Officer. "Strategically, each pa
'/>"/>

SOURCE Parion Sciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. Neurocrine Biosciences to Present at the Oppenheimer 19th Annual Healthcare Conference
2. Human Pheromone Sciences, Inc. - Shareholder Update
3. Carna Biosciences Signs Distribution Agreement with Shanghai Universal Biotech Company
4. Isis Ibis Biosciences Subsidiary Highlights the Power of the Ibis T5000 Pathogen Identification and Characterization System at the ICAAC/IDSA Meeting
5. Caliper Life Sciences Third Quarter 2008 Financial Results Conference Call Notice
6. Advanced Life Sciences Completes Debt Transaction
7. LI-COR Biosciences and Euthanex Corporation Provide Anesthesia System for Small Animal Imaging
8. MedTechIQ Selects TheBrain to Visualize Expansive Biointellingence Database and Connect the Dots Between Life Sciences, Medicine and Venture Capital
9. Neurocrine Biosciences Announces Conference Call and Webcast to Present Third Quarter 2008 Financial Results
10. Sangamo BioSciences Announces Third Quarter Conference Call and Webcast
11. Derma Sciences Announces Multiple Clinical Posters Featuring MEDIHONEY(R) and ALGICELL Ag(R) to be Presented at Upcoming Wound Care Conference

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/30/2009)...HANGHAI, Nov. 30 /PRNewswire-Asia/ -- WuXi PharmaT...chnology, and medical-device research and,developm...nd the United States,announced that it had been s...009 list for the fifth consecutive year. The list ...na,s technology, media, and telecommunications,ind...
(Date:11/30/2009)... , AMSTERDAM, November 30 /PRNewsw...blisher of scientific, medical and technical produ...h of Embase, its comprehensive biomedical,database...more than 7,000,active, peer reviewed journals. ,...advancement of new biomedical,and pharmaceutical i...
(Date:11/28/2009)... The Vanuatu National Advisory Committee on Cli...mmunication (SNC) Project in collaboration with th...Ltd. of New Zealand have generated preliminary cli...orm the background for the country’s SNC rep...on Climate Change (UNFCCC). , ...
(Date:11/27/2009)... November 27 Stallergene...lair(R) in both adults and children,through a Mutu...ry where,Oralair(R) has been marketed, was the ref...registered in Austria, Belgium, Bulgaria, Cyprus, ...ce, Hungary, Ireland, Italy,Latvia, Lithuania, Lu...
Breaking Biology Technology:WuXi PharmaTech Named in Deloitte Technology Fast 50 China 2009 List for the Fifth Consecutive Year 2Elsevier is Re-Launching "Embase" to be a Powerful Resource Providing Deep Insights and Answers to Biomedical Researchers 2Elsevier is Re-Launching "Embase" to be a Powerful Resource Providing Deep Insights and Answers to Biomedical Researchers 3Preliminary Climate and Sea Level Changes for Vanuatu Through the Application of SimCLIM 2Preliminary Climate and Sea Level Changes for Vanuatu Through the Application of SimCLIM 3Preliminary Climate and Sea Level Changes for Vanuatu Through the Application of SimCLIM 4STALLERGENES is Granted a Marketing Authorization for Oralair(R) in Europe 2STALLERGENES is Granted a Marketing Authorization for Oralair(R) in Europe 3
...inhua-PRNewswire-FirstCall/ -- Pharmaxis,Ltd (AXS:...8 Quarterly,Report to Shareholders on the afternoo...l host an investor teleconference the following mo...estions., The teleconference will be on Thursday ...tober at 5.30pm U.S. East Coast, 2.30pm U.S. West ...
..., Oct. 12 Mentice, Inc., a,leading developer and ...ulation systems and Education Management Solutions... and evaluation software solutions, today,announce... symposium in,Washington D.C., an OEM partnership ... standard option to its flagship Vascular Interven...
...x Cardiovascular, Inc., an,Atlanta-based company d...cellular matrix (ECM(TM)) biomaterial devices that...ed cardiovascular tissue, today announced,that Rob...ll present data,on the company,s next generation E...iovascular Therapeutics (TCT) 2008 conference in,W...
Other Biology Technology:Mentice, Inc. and Education Management Solutions, Inc. Form OEM Partnership 2Mentice, Inc. and Education Management Solutions, Inc. Form OEM Partnership 3CorMatrix Cardiovascular to Present Data on Its Next Generation ECM Technology(TM) at Annual Transcatheter Cardiovascular Therapeutics (TCT) Conference in Washington, D.C. 2
(Date:11/24/2009)...cket science is opening new doors to understanding...t the hearing of a marine mammal or if they hear ...ized X-ray scanners that NASA uses to detect flaws...s is now allowing scientists to peek inside the gi...led three-dimensional replicas of a whale,s hearin...
(Date:11/24/2009)...e atomic-level action of a remarkable class of rin...archers with the Lawrence Berkeley National Labora...in crystallography beamline at the Advanced Light ...les in gene expression and replication, and are vi...ll as infectious agents, such as the human papillo...
(Date:11/24/2009)...BATON ROUGE Antarctica has long held secrets of t...ntil recently, there has been very little informat...ath miles of ice for millions of years. Now, a tea... LSU have been funded to the tune of $10 million ..., to get to the bottom of things literally. These...
Breaking Biology News(10 mins):Rocket science leads to new whale discovery 2Atomic-level snapshot catches protein motor in action 2Atomic-level snapshot catches protein motor in action 3Atomic-level snapshot catches protein motor in action 4LSU gets to the bottom of things -- in Antarctica 2Researchers develop new more sensitive assay for detecting DNA methylation in colon cancer 9586 1Researchers develop new more sensitive assay for detecting DNA methylation in colon cancer 9586 2Researchers develop new more sensitive assay for detecting DNA methylation in colon cancer 9586 3Web Is Becoming One Stop Shopping for Health Help 54591 1Web Is Becoming One Stop Shopping for Health Help 54591 2Web Is Becoming One Stop Shopping for Health Help 54591 3Cooling treatment after cardiac arrest is cost effective Penn study shows 54589 1Cooling treatment after cardiac arrest is cost effective Penn study shows 54589 2
...ed by Allison Berrier, PhD, Assistant Professor of...ciences Center New Orleans School of Dentistry, an...ntists design novel approaches to control wound he...is. The paper, β1 Integrin Cytoplasmic Domain...Assembly and Cell Spreading through Talin and Akt-...
...ater and now it turns out (or researchers argue), ... also turns out, the two are swimming in a bit of ...essor in the Department of Biological Sciences at ...han Geisler, associate professor at Georgia Southe...eates a different family tree for the hippo. , Th...
...ed a method that could be used to help figure out ...e, an "escape" that can spread the disease to othe...bed in the March issue of the journal Nature Meth...tudying cell detachment at the subcellular level i...etastasize," says principal investigator Peter Sea...
Other Biology News:Research yields potential target for cancer, wound healing and fibrosis 2Research yields potential target for cancer, wound healing and fibrosis 3Hippo ancestry disputed 2Lab-on-a-chip homes in on how cancer cells break free 2Lab-on-a-chip homes in on how cancer cells break free 3
Equine TNF-alpha / TNFSF1A, Unconjugated from R&D Systems
...ng Checker Kits provide two highly efficient metho...formation without time-consuming plasmid preparati...I, all you need to do is to transfer partial colon...mation plates into the solutions provided by the k...
GRADIENT MAKER, 30 ML from GE Healthcare, formerly Amersham Biosciences
...and G. Butcher (1998). • The major histocompa...n the immunology area. There is great interest in ...n as antigen-presenting molecules. Many immunology...biochemical and genetic techniques in order to stu...
Biology Products: