Navigation Links
Parion Sciences Announces Initiation of Phase I Clinical Trial to Evaluate Safety and Tolerability of GS9411
Date:12/4/2008

DURHAM, N.C., Dec. 4 /PRNewswire/ -- Parion Sciences, Inc. today announced that its partner, Gilead Sciences (Nasdaq: GILD), has initiated a Phase I clinical trial of GS9411 in healthy volunteers to evaluate the safety and tolerability of the investigational compound. GS9411 is designed to increase airway hydration for the treatment of pulmonary disease. Previously known as P-680, GS9411 is an epithelial sodium channel (ENaC) blocker discovered by Parion, a privately held pharmaceutical company focused on treating diseases that result from the failure of the body's mucosal defenses.

The initiation of the Phase I trial triggers a $5 million milestone payment to Parion, according to an exclusive licensing and co-development agreement signed in August 2007 granting Gilead worldwide commercialization rights to GS9411 for the treatment of pulmonary diseases, including cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD) and non-CF bronchiectasis. Parion and Gilead jointly performed the IND-enabling studies for GS9411, and Gilead will assume primary development responsibilities going forward. The two companies are also collaborating on a research program to identify other promising ENaC blocker-based drug candidates utilizing Parion's proprietary ENaC-based chemistry platform.

"This is an important milestone in our program to develop ENaC inhibitors to treat a range of diseases through restoring and maintaining the hydration of mucosal surfaces," said Paul Boucher, Sr. Director, Finance and Business at Parion. "Our partnership with Gilead has enabled us to accelerate development of GS9411 and successfully meet the goals and timelines for this project. We look forward to discovering the potential of this compound to provide a new treatment option for patients suffering from cystic fibrosis, COPD and other s
'/>"/>

SOURCE Parion Sciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Parion Sciences and Kainos Medicines Sign Clinical Development Agreement for Novel Dry Mouth Treatment
2. CeloNova BioSciences Commercializes CATANIA(TM) Coronary Stent With NanoThin Polyzene(R)-F in Europe and Middle East
3. Advanced Life Sciences Announces Cethromycin NDA Accepted for Filing by FDA for the Treatment of Community Acquired Pneumonia
4. DuPont Applied BioSciences Selects MBI to Collaborate on Process Development and Scale-Up for New Bio-based Product
5. Ellen McDonald Joins Regado Biosciences as Senior Vice President of Business Operations and Chief Business Officer
6. Frost & Sullivan Recognizes Martek Biosciences for Unique and Customer-Focused Strategies With Customer Value Enhancement Award
7. Regado Biosciences to Present at the Piper Jaffray Health Care Conference on Tuesday, December 2, 2008
8. Sangamo BioSciences to Webcast Annual Investor and Analyst Briefing and Presentation at Piper Jaffray Health Care Conference
9. Cyntellect Appoints Former BD Biosciences Executive Andre Lubarsky as Director of Sales - North America
10. Intellect Neurosciences, Inc. Issues Letter to Shareholders From Its Chairman and CEO
11. Neurocrine Biosciences to Present at the 20th Annual Piper Jaffray Health Care Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... and PHILADELPHIA , Nov. 26, ... demanding and unforgiving environments. Human exploration of space requires ... to ensure mission safety and success, and prevent potential ... for mission success, little is known about how cognition ... cognition are primarily affected. Now, Penn Medicine ...
(Date:11/26/2014)... The ETC (Emerging Technology Centers) ... announced today that applications for AccelerateBaltimore™ (AB) 2015 ... you have a big idea?,” asked ETC’s President ... about it. AccelerateBaltimore helps you and your big ... 13 weeks.” Interested game changers with “big ...
(Date:11/26/2014)... (PRWEB) November 25, 2014 SonaCare ... Focused Ultrasound (HIFU) devices, recently participated in the ... Renal Mass 360° .” Key opinion leaders in ... advances related to small renal masses while attendees ... different ablative technologies in hands-on labs. Attendees at ...
(Date:11/26/2014)... The Pittcon marketing department is pleased ... exposition mobile app, Pittcon 2015 . ... App Store for iOS and Android devices and the ... during and after the event. It acts as an ... technical sessions, Conferee Networking sessions and short courses. , ...
Breaking Biology Technology:Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 2Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 4AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Pittcon Releases 2015 Mobile App 2
... Extensive Pharmaceutical Experience ... throughout the Region, ... that it has appointed Abdulkader,Al-Mehyar Moh,d Basheer Halawy as sales ... the new sales program with orders for,20,000 units., "These ...
... Biotechnology,International, Inc. (OTC Bulletin Board: YGYB; "Yongye" ... distributor of nutrients for plants and,animals in ... that it closed a,private placement financing with ... Management, pursuant to which the Company issued,6,073,006 ...
... Calif., Sept. 10 Forterus,Inc. (OTC Bulletin Board: ... Inc., its behavioral healthcare subsidiary, is the first,in ... for,individuals with a genetic predisposition for addictive behavior., ... centers in California, A,Better Tomorrow is constantly striving ...
Cached Biology Technology:BioElectronics Corp Aggressively Expands Sales into Middle East 2BioElectronics Corp Aggressively Expands Sales into Middle East 3Yongye Biotechnology International Raises $9.4 Million in Private Placement 2Yongye Biotechnology International Raises $9.4 Million in Private Placement 3A Better Tomorrow Treatment Center Inc., Forterus Inc.'s Behavioral Healthcare Subsidiary, is the First in the Nation to Offer DNA-Customized Treatment for Individuals with a Genetic Predisposition for Addictive Behavior 2
(Date:11/21/2014)... Calif. , Nov. 20, 2014 Strict ... driver efficiency are piloting the North American and European ... of accidents growing, gesture recognition systems that are intuitive ... a mark in the industry. New ... Automotive Gesture Recognition Market in Europe ...
(Date:11/18/2014)...  The Secure Identity & Biometrics Association (SIBA) ... the formation of The Airport Entry and Exit ... and Biometric Entry and Exit Solutions Framework for ... from BORDERPOL, the international non-profit organization that works ... regarding border security, traveler and migration systems. ...
(Date:11/18/2014)... 18, 2014   EyeLock Inc. , a ... MorphoTrust USA (Safran), a leading U.S. ... a strategic partnership to offer comprehensive biometric identity ... (MVA), airport screening and financial services markets. ... serves consumers through a nationwide network of 1,100 ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3
... of consuming dark chocolate and cocoa mounts, there has ... products deliver the most beneficial compounds, known as flavanols, ... the levels of cocoa flavanols. In ... of conventional production methods of cocoa beans on the ...
... , This release is available in French ... is opening today on the grounds of the Botanical Garden. ... University and the Botanical Garden and the Montral Insectarium, two ... cutting-edge scientific facilities for research into biodiversity, its preservation and ...
... by James Henderson, assistant professor of biomedical and ... of Engineering and Computer Science (LCS) and researcher ... memory polymers to provide greater insight into how ... Most cell biomechanics research has examined cell behavior ...
Cached Biology News:Study clarifies the role of cocoa bean handling on flavanol levels 2The University of Montreal Biodiversity Centre opens 2The University of Montreal Biodiversity Centre opens 3Syracuse University research team shapes cell behavior research 2
Mouse monoclonal antibody raised against a partial recombinant ZNF155. NCBI Entrez Gene ID = ZNF155...
... adsorbents are macroporous polystyrene beads for hydrophobic ... area for adsorbing organics of molecular weight ... beads are useful for the adsorption of ... example, the removal of detergents such as ...
... : Fusion protein corresponding to ... human Mi-2 Formulation: 0.7M Tris-glycine, ... sodium azide, containing 30% glycerol ... immunoblot on Hela nuclear extract ...
... Anti-MAPKAPK-2, Phospho-Specific(Thr 222 ... 150 mM NaCl, 10 mM ... 50% glycerol, pH 7.5. Recognizes ... protein kinase 2 (MAPKAPK-2) protein ...
Biology Products: