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Paratek Announces Appointments of Dennis Molnar as Chief Executive Officer and Director and of Dr. Evan Loh as Chief Medical Officer and Chairman of the Board of Directors
Date:5/22/2012

actamase (ESBL) producing Enterobacteriaceae.  As these infections have become increasingly prevalent, omadacycline is being developed by Paratek as a first-line monotherapy that may be reliably used for serious and resistant infections where hospitalization is a consideration.  Omadacycline has been tested in more than 500 healthy subjects, and oral and IV formulations of omadacycline have been compared to Zyvox ® in Phase 2 and Phase 3 clinical studies in more than 350 patients with complicated skin and skin structure infections (cSSSI). The Company believes that omadacycline has the potential to become an alternative for first-line empiric monotherapy in serious community-acquired infections such as CABP and ABSSSI that would potentially avoid the risk of sudden cardiovascular death, bone marrow suppression and kidney toxicity that accompany some other therapies. 

Paratek has an active chemical synthesis effort to produce novel and diverse small molecule tetracycline derivatives that has yielded non-antibacterial compounds with improved activity in serious inflammatory and autoimmune diseases including multiple sclerosis (MS) and rheumatoid arthritis (RA).  In addition, Paratek is developing distinct tetracycline derivatives that specifically modify mRNA splicing, with therapeutic potential in spinal muscular atrophy (SMA).

Paratek has active collaborations with Warner Chilcott and NIH to develop tetracycline-derived small molecule drugs for acne and rosacea and SMA, respectively.  Paratek is privately held and headquartered in Boston, Massachusetts, USA.  For more information, visit Paratek's website at http://www.paratekpharm.com.

CONTACT: Kathryn M. Boxmeyer, Vice President & CFO, Paratek Pharmaceuticals, Inc., +1-617-275-0040 ext. 238, kboxmeyer@paratekpharm.com; Justin Jackson, Burns McClellan, Inc. for
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SOURCE Paratek Pharmaceuticals, Inc.
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