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Panacea Pharmaceuticals' Lung Cancer Diagnostic Test, LC Detect(SM), Named One of Time Magazine's Ten Biggest Medical Breakthroughs of 2007
Date:12/18/2007

h as low-dose spiral computed tomography scans and molecular markers in sputum have not proven to be useful to date.

LC Detect(SM) measures levels of human aspartyl (asparaginyl) beta-hydroxylase (HAAH), a cancer molecular marker, in blood. HAAH has been detected by immunohistochemical staining in a broad range of cancers, including lung cancer, and has been shown to be highly specific and absent in adjacent non-affected tissue as well as tissue from cancer-free individuals. In addition, HAAH protein levels in serum have been demonstrated to be highly sensitive and specific for cancer in hundreds of patients with a range of cancer types, including lung cancer. Panacea has found increased levels of HAAH in the serum of 99 percent of patients with lung cancer (n=160), including those with early-stage disease. In individuals not known to have cancer, HAAH was essentially undetectable in serum (n=93, specificity = 91 percent). In a population of 50 smokers not known to have cancer the mean serum HAAH level was 0 ng/ml.

"Recognition by Time Magazine of the importance of early detect of lung cancer using LC Detect(SM) represents a significant milestone for Panacea, and acknowledgement of the clinical importance of this diagnostic test," cited Hossein Ghanbari, Ph.D., Chairman, CEO and CSO of Panacea Pharmaceuticals, Inc. "Widespread use of LC Detect(SM) should facilitate detection of lung cancer at an earlier stage when effective treatment has a better chance of saving lives and reducing mortality from the number one cancer worldwide."

About Panacea's Oncology Platform

In addition to PC Detect(SM), Panacea offers, CC Detect(SM), a diagnostic test to aide in the detection of colo-rectal cancer, LC Detect(SM), a diagnostic test to aide in the detection of patients with lung cancer, BC Detect(SM), a diagnostic test to aide in the detection of recurrence of breast cancer, and TK Sense(SM), which determines whether white blood cells from patients wi
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SOURCE Panacea Pharmaceuticals
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