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Paloma Pharmaceuticals to Present at the American Association for Cancer Research
Date:4/15/2008

normal vessels to provide nutrients and oxygen. However, above this critical size, cancers utilize angiogenesis to create additional vascular support. Normally, angiogenesis is kept in check by the body naturally creating angiogenic inhibitors to counteract angiogenic factors. However, the cancer cell changes this balance by producing angiogenic growth factors in excess of the angiogenic inhibitors, thus favoring blood vessel growth. Cancer cell induced angiogenesis utilizes common pathways of angiogenesis observed during normal vessel growth. Angiogenic factors pass from the cancer cell to the normal endothelium, binding the endothelial cell, activating it and inducing endothelial signaling events leading to endothelial cell proliferation. Endothelial tubes begin to form, homing in toward the tumor with the formation of capillary loops. Capillaries then undergo a maturation process to stabilize loop structure, but the resulting vessels formed tend to be leaky, structurally aberrant, inefficient and fragile. When formed aberrantly, capillaries induce or promote a variety of pathological conditions in addition to cancer. For example, aberrant neovasculature is found in ocular diseases (such as macular degeneration, diabetic retinopathy and retinopathy of prematurity), arthritis and psoriasis. Under normal conditions, angiogenesis occurs during such conditions as wound healing, repair after myocardial infarction and the female reproductive cycle (generating endometrium forming the corpus luteum and during pregnancy to create the placenta).

About Paloma Pharmaceuticals

Paloma Pharmaceuticals, Inc. is an early stage drug development company focusing on pathologies with a vascular component including cancer, ocular diseases (macular degeneration and diabetic retinopathy), arthritis, fibrotic diseases (pulmonary fibrosis) endometriosis, osteoporosis and skin diseases (psoriasis and atopic dermatitis). Paloma owns the intellectual property relating to a libra
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SOURCE Paloma Pharmaceuticals, Inc.
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