Navigation Links
Paloma Pharmaceuticals to Present at the American Association for Cancer Research
Date:4/15/2008

normal vessels to provide nutrients and oxygen. However, above this critical size, cancers utilize angiogenesis to create additional vascular support. Normally, angiogenesis is kept in check by the body naturally creating angiogenic inhibitors to counteract angiogenic factors. However, the cancer cell changes this balance by producing angiogenic growth factors in excess of the angiogenic inhibitors, thus favoring blood vessel growth. Cancer cell induced angiogenesis utilizes common pathways of angiogenesis observed during normal vessel growth. Angiogenic factors pass from the cancer cell to the normal endothelium, binding the endothelial cell, activating it and inducing endothelial signaling events leading to endothelial cell proliferation. Endothelial tubes begin to form, homing in toward the tumor with the formation of capillary loops. Capillaries then undergo a maturation process to stabilize loop structure, but the resulting vessels formed tend to be leaky, structurally aberrant, inefficient and fragile. When formed aberrantly, capillaries induce or promote a variety of pathological conditions in addition to cancer. For example, aberrant neovasculature is found in ocular diseases (such as macular degeneration, diabetic retinopathy and retinopathy of prematurity), arthritis and psoriasis. Under normal conditions, angiogenesis occurs during such conditions as wound healing, repair after myocardial infarction and the female reproductive cycle (generating endometrium forming the corpus luteum and during pregnancy to create the placenta).

About Paloma Pharmaceuticals

Paloma Pharmaceuticals, Inc. is an early stage drug development company focusing on pathologies with a vascular component including cancer, ocular diseases (macular degeneration and diabetic retinopathy), arthritis, fibrotic diseases (pulmonary fibrosis) endometriosis, osteoporosis and skin diseases (psoriasis and atopic dermatitis). Paloma owns the intellectual property relating to a libra
'/>"/>

SOURCE Paloma Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Palomar and Q-MED AB Enter Into International Distribution Agreement
2. Pacira Pharmaceuticals, Inc. Expands Development Collaborations for DepoFoam(R)
3. Peregrine Pharmaceuticals Announces Four Upcoming Presentations at the American Association for Cancer Research 2008 Annual Meeting
4. Pharmaceuticals & Biotechs to Share Insights for Developing Leaders in a Fast-Paced, Competitive Industry
5. Laureate Pharma Announces Manufacturing Agreement With Alopexx Pharmaceuticals, LLC
6. Diffusion Pharmaceuticals Announces Issuance of U.S. Patent No. 7351844, Titled Bipolar Trans Carotenoid Salts and Their Uses, for Its Family of First-In-Class Molecules
7. BioSpace to Host Regeneron Pharmaceuticals Career Fair in Whippany, New Jersey
8. Microbia Announces Name Change to Ironwood Pharmaceuticals
9. Keryx Biopharmaceuticals Announces Implementation of Strategic Restructuring Plan
10. Memory Pharmaceuticals Receives Nasdaq Notification
11. Anadys Pharmaceuticals to Present at the CanAccord Adams Hepatitis C Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... Bioptigen announced today the availability of ... optical device metrology and pre-clinical ophthalmic research markets. ... Contact Lens Metrology is designed for non-destructive, non-contact, full ... IOL structures, and donor tissues. The metrology ... in a hydration bath (saline), automated segmentation of anterior ...
(Date:9/15/2014)... AUSTIN, Texas , Sept. 15, 2014 The ... changes in climate, says a new article published by the ... Ahmed , PhD, on climate change and its effects on ... part of an extensive study conducted by Dr. Ahmed in ... China and has implications for the future ...
(Date:9/15/2014)... Maryland , 15 de septiembre de 2014 ... se llevará a cabo del 12 al 18 de octubre. ... (PPTA) y de sus compañías miembro s, la ... la concienciación mundial en torno a la colección de fuentes ... donantes de plasma al salvar y mejorar las vidas ...
(Date:9/14/2014)... variety of ways, including by modifying the protein structure. ... form and perform no or even the "wrong" function: ... diseases such as Alzheimer,s, Parkinson,s or cystic fibrosis. Some ... other molecules of the same type and congregate into ... damage cells and tissues and make people ill. , ...
Breaking Biology Technology:Bioptigen Introduces Deep Imaging OCT System for Contact Lens Metrology 2Tea Taste and Quality Affected by Climate Change 2Tea Taste and Quality Affected by Climate Change 3Tea Taste and Quality Affected by Climate Change 4La International Plasma Awareness Week será una celebración para los donantes 2La International Plasma Awareness Week será una celebración para los donantes 3Measuring modified protein structures 2Measuring modified protein structures 3
... Corp . is now using radio frequency identification (RFID) ... the world's largest manufacturer of cordless telephones. , ,RFID ... to engage the supply chain management technology, according to ... integrate passive RFID technology into its supply chain environment. ...
... - Alfalight, Inc., announced the release of ... two configurations for delivery in September. , ,The CPM-II is ... (0.22 NA) output fiber for fiber laser applications. A version ... micron signal/pump fiber) is also available for fiber amplifier and ...
... week before Badger football begins its 2005 season, researchers at ... way to demonstrate their school spirit. The only fans who ... , ,Last month a team of UW-Madison chemists led by ... the university's mascot made of nanofiber hairs each only 75 ...
Cached Biology Technology:Nanotechnology minimizes UW's beloved mascot 2
(Date:9/15/2014)... bonds are produced naturally across all kingdoms of life ... a broad range of biological activities. The presence of ... influence on their molecular properties. , One ... to find the late-stage, site-specific incorporation of a halogen ... sp C-H bond (one of the most inert chemical ...
(Date:9/15/2014)... coral reef ecologists fears that reef biodiversity may not ... we once thought. , In an international study published ... Excellence for Coral Reef Studies (Coral CoE) says we ... within reef ecosystems. , In coral reefs, just as ... keep the ecosystem safe and functioning. , Professor ...
(Date:9/15/2014)... assistant professor in the Department of Science and Technology ... Human Sciences at Virginia Tech, has won a 2014 ... study the prospects and problems of creating a global ... Japan,s Fukushima I Nuclear Power Plant in March 2011 ... viewed nuclear emergencies, Schmid said. Three of the plant,s ...
Breaking Biology News(10 mins):Pitt chemical biologist finds new halogenation enzyme 2Specialized species critical for reefs 2'Nuclear disasters don't respect national boundaries' 2
... wrinkles and hide those pesky grays, but what about ... fix, such as losing muscle mass? Cutting calories early ... the phenomenon in rats. A restricted-calorie diet, ... mitochondrial mishap that may contribute to muscle loss in ...
... This press release is available in French . ... Research Institute of the Jewish General Hospital along with ... Research Institute (OHRI) report a significant breakthrough in the use ... known as oncolytic virotherapy. Their results were published in the ...
... to see a single molecule inside a living cell. ... helping to develop a new technique that will enable ... unprecedented look at the atomic structure of cellular molecules. ... the country and in Germany and Sweden to utilize ...
Cached Biology News:Cutting calories could limit muscle wasting in later years 2Cutting calories could limit muscle wasting in later years 3Viral 'magic bullet' targets cancer cells with help of new compound 2Improving our ability to peek inside molecules 2