Navigation Links
Paloma Pharmaceuticals to Present at the American Association for Cancer Research
Date:4/15/2008

- Presentations highlight Palomid 529 as an anti-angiogenic, anti-tumor

Akt/mTOR inhibitor -

JAMAICA PLAIN, Mass., Apr 15 /PRNewswire/ -- Paloma Pharmaceuticals, Inc. today announced it has presented three presentations at the 2008 annual meeting of the American Association for Cancer Research describing cancer drug Palomid 529 (P529).

P529 is a non-steroidal, synthetic, small molecule dual acting anti-angiogenic and direct anti-tumor agent created through computational design, synthetic and medicinal chemistry, the result of three generations of Palomid design work. Palomid's broad activity as an anti-angiogenic agent and anti-tumor agent is shown to reside in its ability to target and inhibit the PI3K/Akt/mTOR signal transduction pathway as a TORC1/TORC2 inhibitor.

The first of the three presentations, "Palomid 529, a Dual Acting Anti-angiogenic and Direct Anti-tumor Agent Affecting the PI3K/Akt/mTor Pathway," was be given by Dr. David Sherris, President and CEO of Paloma Pharmaceuticals. The second presentation, "Palomid 529 (P529) inhibits tumor angiogenesis and selectively inhibits the Akt but not MAPK signaling pathways," was given by the laboratory of Dr. Laura E. Benjamin of the Department of Pathology and Center for Vascular Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. The last presentation, "Enhancement of radiotherapy in prostate cancer by the dibenzo[c]chrom-6-one derivative P529" was given by the laboratory of Dr. Alfonso Calvo of the Division of Oncology, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.

"mTOR and the protein complexes mTORC1 and mTORC2 are excellent targets for cancer therapy because they provide important signaling links to tumor and stromal pathways dysregulated in many cancers," said Dr. Benjamin whose work has helped to understand the mechanism of action of P529.

"We have shown in a series of prost
'/>"/>

SOURCE Paloma Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related biology technology :

1. Palomar and Q-MED AB Enter Into International Distribution Agreement
2. Pacira Pharmaceuticals, Inc. Expands Development Collaborations for DepoFoam(R)
3. Peregrine Pharmaceuticals Announces Four Upcoming Presentations at the American Association for Cancer Research 2008 Annual Meeting
4. Pharmaceuticals & Biotechs to Share Insights for Developing Leaders in a Fast-Paced, Competitive Industry
5. Laureate Pharma Announces Manufacturing Agreement With Alopexx Pharmaceuticals, LLC
6. Diffusion Pharmaceuticals Announces Issuance of U.S. Patent No. 7351844, Titled Bipolar Trans Carotenoid Salts and Their Uses, for Its Family of First-In-Class Molecules
7. BioSpace to Host Regeneron Pharmaceuticals Career Fair in Whippany, New Jersey
8. Microbia Announces Name Change to Ironwood Pharmaceuticals
9. Keryx Biopharmaceuticals Announces Implementation of Strategic Restructuring Plan
10. Memory Pharmaceuticals Receives Nasdaq Notification
11. Anadys Pharmaceuticals to Present at the CanAccord Adams Hepatitis C Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)...  Saddleback Memorial Medical Center in Laguna ... on the West Coast to perform a hysterectomy using ... women with a state-of-the-art, minimally invasive approach to gynecological ... , M.D., a highly regarded Orange County ... minimally invasive surgery at Saddleback Memorial, led the surgical ...
(Date:5/23/2013)... May 23, 2013 Northwest Biotherapeutics (NASDAQ: ... DCVax ® personalized immune therapies for solid tumor ... at this year,s American Society Of Clinical Oncology (ASCO) ... its leadership role in immune therapy.  (Logo: ... meeting is the pre-eminent conference focused on clinical treatment ...
(Date:5/23/2013)... 23, 2013 Pusan National University Yangsan ... biotherapeutics and contract research company focused on research ... announced today a publication reporting the induction of ... oncolytic and immunotherapeutic vaccinia JX-594 (pexastimogene devacirepvec; Jennerex ... in the May 15 th , 2013 issue ...
(Date:5/23/2013)... May 23, 2013 Watlow®, an ... complete thermal systems, recently introduced its new catalog, ... of experience in designing and manufacturing industrial heaters, ... products to serve diverse customer needs. , A ... at the beginning of the book. These options ...
Breaking Biology Technology:Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 2Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 3NW Bio Exhibit at the Upcoming ASCO Meeting to Highlight its Leadership Role in Immune Therapy for Cancer 2NW Bio Exhibit at the Upcoming ASCO Meeting to Highlight its Leadership Role in Immune Therapy for Cancer 3Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 2Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 3Watlow Introduces Its New Industrial Heater Catalog 2
... Wis. - With plans to erect as many as ... Systems is thinking about needs well beyond its existing ... ,Steve Dickmann, Epic's chief administrative officer, said the company anticipates ... existing employee count of 2,500. In addition, there remains plenty ...
... be the answer to a question you aren't even asking ... connect you with your customers - and your customers with ... your reputation and sales. Here are several potential brand threats ... sophisticated, and suggestions for dealing with them. , , Bad ...
... the lower case "i" next to a word as a way ... and glory may be possible, the chances of creating a long-lasting, ... is the exclusive longevity of its unique name, and for that ... Panasonic and not iTV. , ,Terms like interactive and ...
Cached Biology Technology:Epic Systems will build well beyond current staff size 2Protecting your business against online brand abuse 2Protecting your business against online brand abuse 3The I of the storm: iPhones, iPains, and iProblems 2The I of the storm: iPhones, iPains, and iProblems 3The I of the storm: iPhones, iPains, and iProblems 4
(Date:5/23/2013)... for the overall health, development, and academic success ... in ensuring that all students have opportunities to ... of vigorous or moderate-intensity physical activity, says a ... Recent estimates suggest that only about half of ... better health and development. The report recommends ...
(Date:5/23/2013)... one of the world,s largest and fastest growing ... journal, Frontiers in Bioengineering and Biotechnology . ... specialties, Frontiers in Bioengineering and Biotechnology ... and emerging bioengineering and biotechnology research to be ... Bioengineering and Biotechnology will provide an open-science ...
(Date:5/22/2013)... to improve durability in fuel cell powered buses, ... discovered links between electrode degradation processes and bus ... effects of electrode degradation stressors in the operating ... , The findings of the study, led by ... in a long-term study at Burnaby-based Ballard Power ...
Breaking Biology News(10 mins):Schools should provide opportunities for 60 minutes of daily physical activity to all students 2Schools should provide opportunities for 60 minutes of daily physical activity to all students 3Frontiers launches new open-access journal in Bioengineering and Biotechnology 2Tests lead to doubling of fuel cell life 2
... scientists at the University of Missouri Center for Agroforestry ... can trap and break down veterinary antibiotics in manure ... can be effective in protecting water quality, controlling erosion ... beauty of it," said Keith Goyne, assistant professor of ...
... master gene called SRC-3 (steroid receptor coactivator 3) not only ... the transcription of a genetic message into a protein, it ... cell motility or movement a key element of cancer ... ) researchers and collaborators in a report that appears in ...
... have streamlined the process for synthesizing a family of compounds ... and have found that they represent a unique category of ... of the Journal of the American Chemical Society . ... as the kinamycins, which are naturally produced by bacteria during ...
Cached Biology News:Plant buffers may limit spread of antibiotics in animal waste 2Master gene SRC-3 enables breast cancer growth, invasion 2Scientists synthesize unique family of anti-cancer compounds 2
... This CLS number is ... created to easily match ... showing no availability yet, ... old Sigma-Aldrich number (Z36,327-8) ...
... Grace's medium were developed in several laboratories ... of these modifications were developed by Dr. ... derived from the cabbage looper,Tricoplusia ni. This ... The medium when properly supplemented has been ...
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... T7•Tag ® Ek Adaptor encodes a ... binding site (rbs), ATG translation initation codon, ... T7•Tag is a small epitope tag (11 ... the target protein with T7•Tag Monoclonal Antibody ...
Biology Products: