Navigation Links
PTC Therapeutics Announces Encouraging Additional Phase 2 Results of PTC124 in Cystic Fibrosis
Date:10/5/2007

- New Pediatric Data Presented at 21st North American Cystic Fibrosis

Conference Confirm Previous Findings in Adult population -

SOUTH PLAINFIELD, N.J., Oct. 5 /PRNewswire / -- PTC Therapeutics, Inc. (PTC), a biopharmaceutical company focused on the discovery, development and commercialization of small-molecule drugs targeting post-transcriptional control mechanisms, today announced encouraging data from a Phase 2 clinical trial of PTC124 in pediatric patients with cystic fibrosis (CF) due to a nonsense mutation. These pediatric results and additional information emerging from long-term studies support the existing data from prior short- term studies in adult CF patients. These studies show that treatment with PTC124 results in statistically significant improvements in a measure of the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. These data were highlighted today in a plenary session entitled "CF Drug Development: What's New?" given by Dr. Felix Ratjen, University of Toronto Professor of Pediatrics and Respiratory Medicine Division Chief, at the 21st North American Cystic Fibrosis Conference in Anaheim, California.

(Logo: http://www.newscom.com/cgi-bin/prnh/20010919/PTCLOGO )

Patients with CF lack the CFTR protein, a chloride channel that maintains proper hydration of epithelial cells in the lung, pancreas, and liver. PTC has completed multi-site, open-label, dose-ranging Phase 2 clinical trials in adult CF patients to determine whether PTC124 can induce production of active CFTR protein. Studies in the U.S. and Israel evaluated nasal transepithelial potential difference (TEPD) as a surrogate for CFTR protein production in adult CF patients. Across the two studies, at both PTC124 dose levels tested, TEPD assessments showed statistically significant (p<0.03) improvements of mean CFTR-dependent chloride secretion i
'/>"/>

SOURCE PTC Therapeutics, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. Canadian firm buys Proventiv Therapeutics, makes ex-Bone Care exec CEO
2. Speaker announces business members of IT Task Force
3. Doyle announces technology tax credits for Berbee
4. Doyle announces new energy, global warming policies
5. Doyle announces $80M renewable energy strategy
6. GE announces first installation of Discovery VCT
7. UWM announces winners of RGI awards
8. Third Wave announces two senior management appointments
9. Mirus announces new method for making antibodies
10. Merge announces sofware updates, upcoming acquisition
11. Small Tree announces ethernet solution for Apple Xserv G5
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2015)... (PRWEB) April 30, 2015 SureClinical, a ... Julie I. Morris has joined SureClinical’s executive team as ... experienced biotech and technology executive with over 25 years ... 500 companies. , Ms. Morris joins SureClinical from ... company. She was CFO of MBI from its founding ...
(Date:4/30/2015)... 30, 2015 Sterlitech is proud ... the PX, PY, and PZ Polyacrylonotrile (PAN) ... disks. Designed to be ideal for oil ... can fill critical process requirements where the presence ... , “New regulations on industrial wastewater discharge and ...
(Date:4/29/2015)... April 29, 2015 SPIE DSS, ... imaging on the East Coast, reaffirmed its value last ... applications developers, and industry suppliers to meet and advance ... multiple applications. , The event included 55 conferences in ... scientific sensing and imaging -- and an exhibition showcasing ...
(Date:4/29/2015)... April 29, 2015   Doximity , the leading ... US doctors as members, announced a new, instant method ... Using Doximity." With one click, all US physicians can ... vitae (CV) for an open job opportunity, and a ... Eighty seven percent of physicians are open to ...
Breaking Biology Technology:Julie I. Morris Joins SureClinical as Chief Financial Officer 2Sterlitech Offers New Ultrafiltration Membranes 2SPIE DSS provides venue for collaboration vital to research, applications advances 2SPIE DSS provides venue for collaboration vital to research, applications advances 3SPIE DSS provides venue for collaboration vital to research, applications advances 4Doximity Offering Hospitals Easy, Efficient Physician Application Tool 2
... Trojans hauled that giant wooden statue inside their walls, ... in the streets, people have been examining gift horses ... - within reason. , ,The state Building Commission will ... landmark plan to build the first phase of the ...
... come as a surprise to know that I'm often asked to ... course, a few basic rules of thumb that guide any product ... , Be passionate about the product. , Avoid hokey scenarios. , ... Practice, practice, practice. , ,These are the top-line criteria for a ...
... announced Wednesday that it has begun shipping Gen2 RFID-tagged cases ... Auto-ID research lab in Neenah, Wis., to thank for it. ... of Huggies brand diapers is the company's next step in ... extensive research and testing on the compatibility of Gen2 hardware ...
Cached Biology Technology:Seven good reasons to approve the Institutes for Discovery 2Seven good reasons to approve the Institutes for Discovery 3Secrets of a great demo 2Secrets of a great demo 3Neenah lab helps firm ship RFID-tagged products to Wal-Mart 2
(Date:4/1/2015)... 1, 2015   Medisafe ™, the leading global ... iOS and Android smartphones and ... into the platform to allow patients to track and ... first time, patients will be able to visualize in ... important biometrics, such as glucose levels and blood pressure. ...
(Date:3/26/2015)... , March 26, 2015 The ... social, recreation and athletic club, today announced it has ... allow freedom of movement for members and staff, while ... a comprehensive process, we selected FST,s IMID Access system ... convenience for our members and staff, in addition to ...
(Date:3/24/2015)... , March 24, 2015   Crossmatch ™, ... today announced that its U.are.U ® 4500 ... Goorin Bros . to achieve PCI compliance ... secures access to the POS terminal, protecting the ... of data breaches. With one-third ...
Breaking Biology News(10 mins):Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2
... Institute (NHGRI), one of the National Institutes of Health ... will target 13 more organisms as part of its ... biological knowledge and improve human health. , The National ... a federally chartered committee that advises NHGRI on program ...
... Ever wondered why you aren't able to swat a fly? ... in its decision to jump rather than to fly out ... of interest to those building autonomously navigating robots", according to ... be presenting her work on triggered escape response at the ...
... first time, scientists have identified an ant species that ... , Stanford University biologist Deborah M. Gordon and ... issue of the journal Nature. The discovery was made ... student Megan E. Frederickson in the Amazon jungle of ...
Cached Biology News:NHGRI Selects 13 More Organisms for Genome Sequencing 2NHGRI Selects 13 More Organisms for Genome Sequencing 3NHGRI Selects 13 More Organisms for Genome Sequencing 4NHGRI Selects 13 More Organisms for Genome Sequencing 5Ants, not evil spirits, create devil's gardens in the Amazon rainforest, study finds 2Ants, not evil spirits, create devil's gardens in the Amazon rainforest, study finds 3Ants, not evil spirits, create devil's gardens in the Amazon rainforest, study finds 4
Extra Large bottle for hybridization 300 x 70mm...
Request Info...
... The Thermo IEC Microtube Rotor is ... have to change rotors. You can ... and PCR tubes. Exclusive polypropylene rotor design ... repeatedly autoclaved. Polypropylene rotors are fully ...
... Wellpro 384, compatible with ... liquid handling system for ... and accurately prepares large ... The Wellpro also ...
Biology Products: