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PROLOR Biotech Awarded Two U.S. Patents for Its Longer-Acting Human Growth Hormone and Longer-Acting Erythropoietin
Date:6/30/2009

NES-ZIONA, Israel, June 30 /PRNewswire-FirstCall/ -- PROLOR Biotech, Inc. (OTC Bulletin Board: PBTH), formerly Modigene Inc., today announced that the U. S. Patent and Trademark Office (PTO) has issued two new patents for the company's long-acting CTP-enhanced human growth hormone (hGH-CTP) and human erythropoietin (EPO-CTP). The patents cover the composition of PROLOR's proprietary pharmaceutical compounds as well as certain associated methods. PROLOR's CTP technology is based on a short amino acid sequence, the Carboxyl Terminal Peptide that occurs naturally in humans. When attached to a therapeutic protein, CTP extends the time that the protein is active in the body.

"These two new patents covering CTP-enhanced human growth hormone and erythropoietin represent another significant layer of protection within our CTP-based intellectual property portfolio," said Shai Novik, president of PROLOR. "We have also filed several other patent applications for additional CTP-enhanced long-acting therapeutic proteins and peptides that are currently pending. We are confident that our growing CTP patent estate will provide excellent protection for both our compounds under development and for our innovative and versatile platform technology, and we believe it will serve as an important value driver for PROLOR in the future."

The potential utility of the CTP technology has been demonstrated by Schering-Plough, which is developing the technology for fertility applications only. Data from its Phase III ENGAGE trial demonstrated that women receiving a single injection of the fertility drug FSH-CTP achieved the same pregnancy rates as women receiving seven consecutive daily injections of commercial FSH. This 1,509 patient trial, which was the largest double-blind fertility trial ever conducted, formed the basis for a Marketing Authorization Application by Schering-Plough that is under review by the European Medicines Agency.

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SOURCE PROLOR Biotech, Inc.
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