Navigation Links
PDS Biotechnology reports positive Phase I clinical trial results in proprietary HPV-Cancer Immunotherapy

NORTH BRUNSWICK, N.J., May 28, 2015 /PRNewswire/ -- PDS Biotechnology Corp. announces preliminary data showing that PDS0101, a cancer immunotherapy treatment targeting HPV-16, has generated strong T-cell responses in pre-cervical cancer patients. 

Currently, pre-cervical cancer is treated by surgical removal of lesions however, PDS0101 could offer a simple and effective non-surgical alternative. Results show that it primes and activates the body's defense mechanisms (T-cells) to recognize, target, and kill precancerous and cancerous cells that display HPV viral proteins, which are responsible for over 99% of cervical cancers.  All patients who had little to no pre-treatment immune responses to HPV-16, the population most likely to progress to invasive cancer, generated robust T-cells targeting HPV.

These promising clinical results from all four patients in this ongoing trial is the first demonstration of PDS Biotechnology's proprietary synthetic immunotherapy technology, Versamune's®, application in human cancer. The results mirror its preclinical data which showed strong T-cell responses and aggressive tumor regression with low doses of the product. 

The combination of Versamune's® human efficacy and safety profile is an important step towards the development of next generation therapies to treat both early and late stage cancers. It also suggests that the Versamune®-based products will be uniquely suited for use in combination with other immuno-oncology platforms to develop powerful therapies.

Dr. Frank Bedu-Addo, PDS President and CEO, said: "We are encouraged by these positive first-in-man results that help validate the potential for a wide range of simple, safe and powerful Versamune®-based immunotherapies to generate the right type of T-cells to kill cancer cells.

"We now plan to conduct two Phase II clinical trials, in late-stage cervical intra-epithelial neoplasia (CIN) and cervical cancer, to study Versamune's® ability to reduce the amount of specific immune suppressive cells and overcome a tumor's immunosuppressive environment."

About PDS Biotechnology

PDS Biotechnology is a clinical-stage biotechnology company developing a new generation of simpler, more effective and safer cancer immunotherapies.  The company owns the proprietary Versamune® immunotherapy platform.  PDS0101 is the company's lead cancer immunotherapy in development to treat HPV-induced cancers.  PDS Biotechnology has established key partnerships to develop the company's oncology and infectious disease pipelines.  For more information on PDS biotechnology please visit

About Versamune®

Versamune® is a first-in-class synthetic technology that efficiently accesses an immunological pathway known as the MHC Class-I pathway, a key to activating effector killer T-cells called CD8+ T-cells.  Versamune® also activates the induction of important proteins called chemokines which cause the generation of robust CD8+ T-cell responses. Certain formulations of Versamune® have been demonstrated to reduce the population of immune suppressive cells, thus making the T-cells significantly more effective in their tumor killing function.   

About HPV-Caused Cancers

Human papillomavirus (HPV) plays a key role in the development of several cancers including cervical intraepithelial neoplasia (pre-cancer), cervical cancer, head and neck cancers and anal cancer, and is the most common sexually transmitted agent worldwide. Approximately 78 million Americans are believed to be infected with HPV and 420,000 Americans are diagnosed with CIN each year. Approximately 13,000 new cases of invasive cervical cancer are diagnosed each year.

SOURCE PDS Biotechnology Corporation
Copyright©2015 PR Newswire.
All rights reserved

Related biology technology :

1. Optivia Biotechnology Inc. and Rhenovia Pharma Sign Partnership Agreement
2. Beike Biotechnology Produces High-dose Adult Stem Cell Packets for Degenerative Conditions
3. Global Separation Systems Market in Biotechnology 2015-2019 - Trends and Forecasts for the $28 Billion Market
4. Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness
5. Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola
6. Biotechnology Manufacturer Nitto Avecia Expands Capacity to Meet Client Demand
7. Biorem Engineering and Syngulon Sign a Strategic Partnership: The Alliance of Green Chemistry and White Biotechnology
8. Quarterly Report Card of Biotechnology Companies: New Research on Sunshine Heart, Synergetics USA, Syneron Medical, Spectranetics and Thoratec
9. Global Agricultural Biotechnology Market is Expected to Reach USD 28,694.1 Million in 2019 : Transparency Market Research
10. Vigilant Biosciences, Inc. Expands Executive Leadership Team and Board of Directors with Veteran Biotechnology and Diagnostics Executives
11. Global Animal Biotechnology Technologies, Markets and Companies Report 2015-2024
Post Your Comments:
(Date:7/31/2020)... ... July 30, 2020 , ... ... today announced the release of its signature product called Beacon - a ... and other field medical professionals. , Beacon helps MSLs streamline communication ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... aid in the early detection and prevention of high-burden diseases, and Centric Consulting, ... hospitals and healthcare organizations to utilize existing data in order to identify and ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most research using the ... pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over ... been using the zebrafish model to investigate the causes of leukaemia and its ...
(Date:7/1/2020)... ... June 29, 2020 , ... MedShift , a ... 2020, despite many obstacles created as a result of COVID-19. As a provider ... partnered medical practices and medical manufacturers by expanding access to device offerings, technology ...
Breaking Biology Technology:
(Date:8/21/2020)... ... 2020 , ... “How can we help?”, asks Hans Schroeder, ... for more than twenty years. Together with Douglas Granger, Ph.D., founder of Salimetrics ... of Interdisciplinary Saliva Research and Applications ," and Steven Granger, Ph.D., Chief Scientific ...
(Date:8/12/2020)... ... 12, 2020 , ... Mosio recently announced its newly updated ... agencies of all sizes. With a focus on tracking symptoms and monitoring outbreaks ... care, Mosio helps public health departments automate communications and provide more personalized care ...
(Date:8/3/2020)... ... August 03, 2020 , ... Accumen Inc. is helping healthcare ... manufacturer, Spectrum Solutions, to provide COVID-19 saliva testing kits nationally. , “Accumen ... more than 10 years. Early in the COVID-19 crisis, we identified supply chain ...
Breaking Biology News(10 mins):