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Overview of CSL Behring Innovations in Recombinant Technologies Presented at International Conference
Date:5/19/2011

KING OF PRUSSIA, Pa., May 19, 2011 /PRNewswire/ -- Advances that CSL Behring is making in developing innovative new technologies to meet the unmet therapeutic needs of patients with hemophilia A and B will be the topic of an oral presentation at an international medical congress on May 22, 2011. CSL Behring is a global biotherapeutics company specializing in plasma-derived and recombinant therapies and is a subsidiary of CSL Limited (ASX:CSL).

CSL627, a unique single-chain recombinant factor VIII (rFVIII) studied for treatment of hemophilia A, will enter phase I clinical testing.

The structure of factor VIII (FVIII) is based on two linked protein chains—a heavy one and a light one. Under certain conditions, this structure can dissociate, resulting in the formation of separated, or "dissociated," FVIII chains. CSL627 uses a strong, covalent bond that connects the light and heavy chains, thereby creating a single-chain rFVIII.

In-house studies have shown that the molecular integrity of CSL627 is significantly increased using this single-chain design, resulting in a homogenous product that may be more stable than currently available options. In addition, in-vitro studies have shown that CSL627 demonstrates a very strong affinity for von Willebrand factor (VWF) and a faster and more efficient binding to VWF than is demonstrated in wild-type FVIII. The FVIII/VWF complex plays an important role in the physiological activity and clearance of FVIII and has been shown to have an influence on the presentation of FVIII to the immune system.

"For more than 90 years, CSL Behring has been committed to providing safe and effective therapies to help improve the lives of patients and caregivers affected by hemophilia A and other rare bleeding disorders," said  Dr. Andrew Cuthbertson, Chief Scientist, CSL Limited. "Developing innovative therapeutic solutions to se
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