Navigation Links
Otonomy's OTO-104 Demonstrates Hearing Loss Protection and Hearing Recovery in Preclinical Studies
Date:2/22/2011

Pre-treatment with OTO-104 was also shown to provide nearly complete protection against hearing loss induced by cisplatin, a standard anti-cancer drug.  In each of these studies, hearing loss was evaluated using auditory brainstem response (ABR) which is a quantifiable measure of hearing function.

OTO-104 is a sustained release dexamethasone gel designed for direct injection into the middle ear as a potential treatment for hearing loss and balance disorders.  Otonomy's proprietary formulation is intended to overcome the limitations associated with short acting solutions which include the need for multiple IT injections and large variability of delivered dose.  In addition to its work in the area of hearing loss, the company is also currently conducting a prospective, randomized, placebo-controlled, multicenter, Phase 1b study of OTO-104 given as a single IT injection for the treatment of unilateral Meniere's disease.  While the primary endpoint of the study is safety and tolerability, a number of additional endpoints are being monitored, including the frequency of vertigo attacks experienced by patients pre- and post-treatment.  

According to the National Institute on Deafness and Other Communication Disorders (NIDCD), approximately 17 percent (36 million) of American adults report some degree of hearing loss.  Furthermore, the NIDCD estimates that approximately 15 percent (26 million) of Americans between the ages of 20 and 69 have high frequency hearing loss due to noise exposure at work or during leisure activities.  In addition, there are more than 1 million cancer patients, including children, treated each year with chemotherapeutic agents known to cause irreversible hearing loss according to the United Kingdom's Royal National Institute for Deaf People (RNID).

About OtonomyOtonomy is a clinical stage biopharmaceutical company developing novel drug therapies for diseases and disorders of the inner and
'/>"/>

SOURCE Otonomy, Inc
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. SAFC Hitech(TM) Successfully Demonstrates Device-Quality GST Precursors For Phase Change Memory Applications
2. SuperGens MP-470 Demonstrates Clinical Tumor Regression When Combined with Standard of Care Chemotherapy
3. EntreMeds ENMD-2076 Demonstrates Tumor Regression in Human Colon Cancer Model
4. Vaxart Demonstrates Efficacy of Oral Avian Flu Vaccine in Preclinical Studies
5. Study From the University of Texas M.D. Anderson Cancer Center Demonstrates That AHCC(R) is Safe in Combination With Most Chemotherapeutic Agents
6. RVX-208 Data Demonstrates Increase in Functional HDL Particles
7. Antheras Varespladib Demonstrates Significant Anti-Inflammatory Effect and LDL Reduction in Patients With Coronary Heart Disease
8. Human clinical study demonstrates superior Neptune Krill Oil NKO(R) pharmacokinetic profile
9. Sparta Systems Demonstrates Global Enterprise Quality Management Leadership at TrackWise(R) Connection User Conferences
10. Epilepsia Study Demonstrates New Add-on Antiepileptic Drug Vimpat(R) (lacosamide) Significantly Reduces Partial-Onset Seizures in Adults With Epilepsy
11. First Multiple Dose Clinical Trial of TorreyPines Therapeutics Oral Compound NGX426 Demonstrates Compound Is Safe and Well-Tolerated
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... Paul, Minnesota (PRWEB) September 19, 2014 ... from related food industries will gather October 5–8, ... at the Rhode Island Convention Center in Providence, ... will feature the work of food scientists, chemists, ... quality control, and food production management. To date, ...
(Date:9/18/2014)... HealthTronics, Inc ., a ... products and services, announced that a poster related ... versus external beam radiotherapy (EBRT) is being presented ... Association (MAAUA) Annual Meeting in Baltimore, Maryland September ... Cryosurgery and External Beam Radiation as Treatments for ...
(Date:9/18/2014)... September 18, 2014 ... http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced the addition ... Global Strategic Business Report" report ... ,This report analyzes the worldwide markets ... by the following Product Segments: Polymeric ...
(Date:9/18/2014)... 2014 Research and Markets has ... Industry Report 2014" report to their offering. ... is a professional and in-depth study on the current ... The report provides a basic overview of the industry ... human albumin market analysis is provided for the international ...
Breaking Biology Technology:Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3
... , SAN DIEGO, Sept. 22 ... services, introduces the TurboLink Conjugation Catalyst, making conjugation at least ... antibodies, oligos, peptides and proteins. , , ... have traded conjugation speed for poor yields, poor quality and ...
... , ... Opportunities as Other Sectors Struggle , ... Minneapolis (Vocus) – Medical real estate continues to be one of the bright spots ... the most recent edition of the Healthcare Real Estate Insights (HREI) newsletter., , , , ...
... ... an oncology contract research organization in the US and Europe, is ... Inder Makin, M.D., Ph.D., who joins the company as Vice President, ... throughout the product life cycle including early design and prototyping, simulation, ...
Cached Biology Technology:SoluLinK Introduces Product that Links All Biomolecules Greater Than 20 Times Faster with 100% Yields 2Deals keep Coming in Medical real Estate 2Medelis Expands CRO Services to Medical Devices, Appoints Dr. Inder Makin as VP 2Medelis Expands CRO Services to Medical Devices, Appoints Dr. Inder Makin as VP 3
(Date:9/18/2014)... The ability to acquire and creatively manipulate spoken language ... over the past 6 million years of human evolution ... is the best candidate gene we now have," says ... LMU. In his efforts to understand the molecular biological ... step forward. The results of his latest study, undertaken ...
(Date:9/18/2014)... have built the first smartphone app that automatically ... trends. In other words, your smartphone knows your ... -- and how that affects you. , The ... and loneliness to their academic performance, also may ... example, to monitor mental health, trigger intervention and ...
(Date:9/18/2014)... Va.Sept. 18, 2014Many Americans across racial and ethnic ... greatest impact on their day-to-day life, more so ... hearing and speech (57% of African-Americans, 49% of ... Hispanics). When asked which disease or ailment is ... ranked first among African-Americans followed by AIDS/HIV. ...
Breaking Biology News(10 mins):Language evolution: Quicker on the uptake 2Language evolution: Quicker on the uptake 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 4Americans rate losing eyesight as having greatest impact on their lives 2Americans rate losing eyesight as having greatest impact on their lives 3
... the world go ,round they comprise most of the Earth,s ... that keep the planet, and life in and on it, going. ... is the carbon cycle, which is currently unbalanced. Humans release more ... Deal with Carbon: How Earth,s Mighty Microbes Respond," is a free ...
... May 6, 2011 Cancer researchers at UT Southwestern ... telomerase enzyme, which is linked to the disease,s growth. ... demonstrate that telomerase repairs chromosomes in one of two ways ... if the cell is under stress from enzyme inhibition ...
... Scientists have known for years that seizures in patients ... they did not know was why this was happening. ... by Professor Wilma Friedman of the Department of Biological Sciences ... a recently awarded, four-year, $2 million grant from the National ...
Cached Biology News:UT Southwestern research reveals how cancer-driving enzyme works 2Following trail of cell death in epilepsy patients to find ways to preserve brain health 2
...
Anti-Human Factor XI Purified (Polyclonal) (sheep IgG)...
Rabbit polyclonal to Wilms Tumor Protein ( Abpromise for all tested applications). entrezGeneID: 7490 SwissProtID: P19544...
Goat polyclonal to Dysadherin ( Abpromise for all tested applications). entrezGeneID: 53827...
Biology Products: