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Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets
Date:4/11/2008

trum, anti-tumor activity for three new compounds. These compounds selectively target specific pathways and influence the interaction between cancer cells and the microenvironment to induce cancer cell death. The presentations include:

- JNJ-26854165, a first-in-class, first-in-clinic Hdm2 inhibitor which induces apoptosis (programmed cell death) in a number of cancer cell lines, and restores function of the p53 tumor suppressor protein through a novel mechanism of action; the compound is in phase I studies for non-small cell lung cancer and prostate cancer. (Oral abstract #1592)

- JNJ-26481585, a novel, second-generation pan-Histone Deacetylase (HDAC) inhibitor with anti-tumor activity against solid and hematological malignancies, which interferes with expression of genes that control cancer cell proliferation, angiogenesis and metastasis; phase I trials are ongoing. (Oral abstract #2444)

- JNJ-38877605, a small molecule that selectively and potently inhibits the c-Met receptor tyrosine kinase (c-Met RTK) pathway that regulates inhibition of signaling from the microenvironment to block cancer cell development and metastasis; based on promising pre-clinical properties and clean toxicity profile of JNJ-38877605, ORD has advanced this potent and uniquely selective c-Met inhibitor into clinical evaluation in multiple metastasized malignancies. (Poster abstract #4837)

"These new agents are just a few of the novel compounds from our pipeline that we hope may lead to the control of cancer," Dr. Hait said. "The scientific community is attempting to identify all the genetic abnormalities within cancer cells; this has yielded a finite number of treatment opportunities. The scientific approach of ORD has the potential to generate new opportunities to improve cancer care."

About Our Compound Targets

Human Double Minute 2 (Hdm2)

The Hdm2 oncogene is activated in cancers through various mechanisms, including gene amplification and
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