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Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets
Date:4/11/2008

SAN DIEGO, California, April 11 /PRNewswire/ --

- Newly Established Organization Presents Data on Advancing Compounds at AACR -

Ortho Biotech Oncology Research & Development (ORD), a unit of Johnson & Johnson Pharmaceutical Research & Development, L.L.C., will announce results from studies of three innovative compounds--Hdm2, c-Met, and HDAC inhibitors --here at the American Association for Cancer Research (AACR) 2008 Annual Meeting.

"ORD is a new research and development organization that unites the biotechnology and pharmaceutical oncology efforts of several Johnson & Johnson companies with the goal of transforming cancer into a chronic or curable disease," said William Hait, M.D., Senior Vice President and Worldwide Head of Ortho Biotech Oncology Research & Development. "The new organization harnesses broad, multi-disciplinary capabilities and expertise in order to prioritize existing and emerging opportunities, align cancer treatment with modern cancer biology and improve patients' lives."

ORD's scientific approach to cancer examines the cancer cell and the surrounding tissue, or microenvironment. Previously, researchers often studied cancer as collections of malignant cells growing in isolation, but now understand cancer cells depend on interactions with the surrounding tissue to survive, grow and metastasize. ORD seeks to identify compounds which can inhibit or block the interaction cancer cells have with the surrounding tissues, which compromises the cancer's ability to survive.

The organization will combine the microenvironment disruptive agents (MDAs) resulting from this approach with classic treatments that directly target cancer cells. MDAs represent one of the most promising areas of drug discovery, and ORD has a pipeline of several investigational MDAs, including some of which are first-in-class and first-in-clinic.

Pre-clinical data presented at this year's AACR meeting demonstrate evidence of broad-spec
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SOURCE Ortho Biotech
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