Navigation Links
Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets

SAN DIEGO, California, April 11 /PRNewswire/ --

- Newly Established Organization Presents Data on Advancing Compounds at AACR -

Ortho Biotech Oncology Research & Development (ORD), a unit of Johnson & Johnson Pharmaceutical Research & Development, L.L.C., will announce results from studies of three innovative compounds--Hdm2, c-Met, and HDAC inhibitors --here at the American Association for Cancer Research (AACR) 2008 Annual Meeting.

"ORD is a new research and development organization that unites the biotechnology and pharmaceutical oncology efforts of several Johnson & Johnson companies with the goal of transforming cancer into a chronic or curable disease," said William Hait, M.D., Senior Vice President and Worldwide Head of Ortho Biotech Oncology Research & Development. "The new organization harnesses broad, multi-disciplinary capabilities and expertise in order to prioritize existing and emerging opportunities, align cancer treatment with modern cancer biology and improve patients' lives."

ORD's scientific approach to cancer examines the cancer cell and the surrounding tissue, or microenvironment. Previously, researchers often studied cancer as collections of malignant cells growing in isolation, but now understand cancer cells depend on interactions with the surrounding tissue to survive, grow and metastasize. ORD seeks to identify compounds which can inhibit or block the interaction cancer cells have with the surrounding tissues, which compromises the cancer's ability to survive.

The organization will combine the microenvironment disruptive agents (MDAs) resulting from this approach with classic treatments that directly target cancer cells. MDAs represent one of the most promising areas of drug discovery, and ORD has a pipeline of several investigational MDAs, including some of which are first-in-class and first-in-clinic.

Pre-clinical data presented at this year's AACR meeting demonstrate evidence of broad-spectrum, anti-tumor activity for three new compounds. These compounds selectively target specific pathways and influence the interaction between cancer cells and the microenvironment to induce cancer cell death. The presentations include:

- JNJ-26854165, a first-in-class, first-in-clinic Hdm2 inhibitor which induces apoptosis (programmed cell death) in a number of cancer cell lines, and restores function of the p53 tumor suppressor protein through a novel mechanism of action; the compound is in phase I studies for non-small cell lung cancer and prostate cancer. (Oral abstract #1592)

- JNJ-26481585, a novel, second-generation pan-Histone Deacetylase (HDAC) inhibitor with anti-tumor activity against solid and hematological malignancies, which interferes with expression of genes that control cancer cell proliferation, angiogenesis and metastasis; phase I trials are ongoing. (Oral abstract #2444)

- JNJ-38877605, a small molecule that selectively and potently inhibits the c-Met receptor tyrosine kinase (c-Met RTK) pathway that regulates inhibition of signaling from the microenvironment to block cancer cell development and metastasis; based on promising pre-clinical properties and clean toxicity profile of JNJ-38877605, ORD has advanced this potent and uniquely selective c-Met inhibitor into clinical evaluation in multiple metastasized malignancies. (Poster abstract #4837)

"These new agents are just a few of the novel compounds from our pipeline that we hope may lead to the control of cancer," Dr. Hait said. "The scientific community is attempting to identify all the genetic abnormalities within cancer cells; this has yielded a finite number of treatment opportunities. The scientific approach of ORD has the potential to generate new opportunities to improve cancer care."

About Our Compound Targets

Human Double Minute 2 (Hdm2)

The Hdm2 oncogene is activated in cancers through various mechanisms, including gene amplification and deletion of upstream tumor suppressors. Hdm2 over-expression induces tumor formation, and Hdm2 levels correlate with sporadic tumor incidence in humans(i). Hdm2 promotes tumor cell proliferation by associating with cell cycle regulatory proteins, modulating their activity and stability. Key examples include p53, p73, E2F1 and HIF1a(ii),(iii). This positions the Hdm2 protein as an attractive target for the development of anti-cancer agents.

Histone Deacetylase (HDAC)

DNA in chromatin is wound around proteins called histones. HDACs are a family of enzymes that influence gene expression through selective regulation of chromatin structure. Inappropriate gene expressions, due to changes in chromatin structure, are a hallmark of cancer. HDAC inhibitors aim to normalize chromatin structure, thereby restoring the activity of genes which inhibit proliferation, angiogenesis and metastasis(iv).

c-Met Receptor Tyrosine Kinase (c-Met RTK)

Receptor tyrosine kinases (RTKs) are cell surface receptors that regulate many key processes including invasive growth and cell survival. The c-Met RTK pathway has been shown to be specifically important in regulation of cell migration and invasion, cell proliferation, survival and angiogenesis. Deregulation of c-Met RTKs has been implicated in the development and progression of numerous human cancers. The c-Met RTK inhibitors prevent receptor activation and thus inhibit tumor cell development and metastasis(v),(vi),(vii),(viii).

About ORD

Ortho Biotech Oncology Research & Development (ORD) is a new research and development organization dedicated to oncology, hematology and supportive care. ORD partners closely with Ortho Biotech Products, L.P. and Janssen-Cilag companies worldwide to bring oncology treatments and supportive medicines to patients around the world. ORD is headquartered in Raritan, N.J., and has facilities throughout Europe and the United States.

(This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or unknown risks or uncertainties materialize, actual results could vary materially from the Company's expectations and projections. Risks and uncertainties include general industry conditions and competition; economic conditions, such as interest rate and currency exchange rate fluctuations; technological advances and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approvals; domestic and foreign health care reforms and governmental laws and regulations; and trends toward health care cost containment. A further list and description of these risks, uncertainties and other factors can be found in Exhibit 99 of Johnson & Johnson's Annual Report on Form 10-K for the fiscal year ended December 30, 2007. Copies of this Form 10-K, as well as subsequent filings, are available online at, or on request from Johnson & Johnson. Johnson & Johnson does not undertake to update any forward-looking statements as a result of new information or future events or developments.)

(i) Bond GL, Hu WW, Bond EE, Robins H, Lutzker SG, Arva NC, Bargonetti J, Bartel F, Taubert H, Wuerl P, Onel K, Yip L, Hwang SJ, Strong LC, Lozano G, Levine AJ. A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumour Suppressor Pathway and Accelerates Tumour Formation in Humans. Cell; 2004; 119: 591-602.

(ii) Levine, A J; Hu, W; Feng, Z. The P53 pathway: what questions remain to be explored? Cell Death and Differentiation; 2006, 13(6), 1027-1036.

(iii) Toledo F, Wahl GM. MDM2 and MDM4: p53 regulators as targets in anticancer therapy. International Journal of Biochemistry & Cell Biology; 2007, 39(7-8):1476-82.

(iv) Johnstone, RW. Histone deacetylase inhibitors: novel drugs for the treatment of cancer. Nature Reviews Drug Discovery; 2002, 1, 287 - 299.

(v) Lesko, E and Majka, M. The biological role of HGF-MET axis in tumor growth and developmentof metastasis. Fron Biooscie; 2008, 13: 1271-80.

(vi) Sattler, M and Salgia R. c-Met and hepatocyte growth factor; potential as novel targets in cancer theray. Curr Oncol Rep; 2007, 9 (2) 102-8.

(vii) Boccaccio C, and Comoglio, PM. Invasive growth; a MET driven genetic programme for cancer and stem cells. Nat Rev Cancer; 2007, 6(8) 637-45.

(viii) Peruzzi, B and Bottaro, DP. Targeting the c-Met signaling pathway in cancer. Clin Cancer Res; 2006, 12(12) 3657-60.

SOURCE Ortho Biotech
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. Ortho Biotech Modifies Prescribing Information for PROCRIT(R) (Epoetin alfa)
2. Osteotech to Present at the Canaccord Adams Small-Cap Orthopedics Conference in San Francisco
3. ROBODOC(R) Emerges as a Curexo Technology Company at Upcoming Orthopaedic Surgeons Conference in San Francisco
4. NuVasive to Present at Canaccord Adams Small-Cap Orthopedics Conference
5. SyntheMed to Present at Canaccord Adams Small-Cap Orthopedics Conference
6. Ortho Biotech Statement On JAMA Publication Regarding Erythropoiesis-Stimulating Agents
7. Symmetry Medical to Present at Canaccord Adams Small-Cap Orthopedics Conference
8. Kensey Nash to Present at the Canaccord Adams Small-Cap Orthopedics Conference
9. Barr and Ortho Womens Health & Urology in Discussions to Settle ORTHO TRI-CYCLEN(R) LO Patent Litigation
10. Progentix Orthobiology B.V. Closes Series A Financing Round
11. Ortho Biotech Modifies Prescribing Information for PROCRIT(R) (Epoetin alfa) Label Reflects Recommendations from Recent FDA Advisory Committee Meetings
Post Your Comments:
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology:
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):