Asenapine at doses up to 20 mg twice daily had a minimal, not considered to be clinically relevant, effect on QTc. Asenapine had an effect equal to or less than quetiapine on QTc in this study.
The study abstract, "Effect of asenapine versus quetiapine and placebo on QTc interval in patients with schizophrenia," (P.3.c.050) was presented at ECNP on Sunday, 14 October by Sheldon H. Preskorn, M.D., Department of Psychiatry, University of Kansas School of Medicine in Wichita.
About bipolar disorder
Bipolar disorder, commonly referred to as manic-depressive disorder, is a chronic, episodic illness characterized by mania (episodes of elevated moods, extreme irritability, and increased energy), depression (overwhelming feelings of sadness, suicidal thoughts), or a combination of both. It affects approximately one to five percent of adults, including more than 10 million adults in the United States and more than four million people in Europe (2,3). The condition can start early in childhood or later in life, the average age of onset is between 15 and 25 years old (4). Bipolar disorder is the sixth leading cause of disability in the world (2). About half of the patients with bipolar disorder who recover in response to treatment experience recurrence two years later (5).
Schizophrenia is a chronic, disabling brain disorder characterized by hallucinations, delusions, and disordered thinking. About 24 million people worldwide (or seven in every 1,000 adults in the population) have schizophrenia (6), including more than two million people in the U.S. (7) and more than four million people in Europe (8). People with schizophrenia may hear voices other people don't hear or may believe others are trying to harm them. As a result, they may become socially withdrawn, fearful, and agitated (7).
1. National Institute of Mental Health. Available online at:
Copyright©2007 PR Newswire.
All rights reserved