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Organizational Changes at Silence Therapeutics
Date:7/17/2008

LONDON, July 17 /PRNewswire/ -- Silence Therapeutics plc (London AIM: SLN), a leading European RNAi focused biotechnology company, announces that for personal reasons, Jeffery Vick has resigned as Group CEO and left the Company.

The Board of Directors has appointed Iain Ross, currently Non-Executive Chairman, full time Chairman and Group CEO with immediate effect. Jeremy Curnock Cook, a Non-Executive Director of the Company has been appointed Senior Independent Non-Executive Director.

On behalf of the Board of Silence Therapeutics plc, Jeremy Curnock Cook said:

"Iain Ross was responsible for the financial and operational turnaround of the Company from July 2004 until July 2007, and the Silence Board of Directors is confident that under his executive leadership, significant shareholder value can be generated. Iain is an experienced business negotiator and we believe he can bring to fruition a number of deals and collaborations currently under discussion."

Iain Ross, Chairman & CEO added:

"I believe that by employing a more focused and aggressive approach, and with the continued support of a first class management team, we can achieve meaningful technical and commercial milestones over the next 12 months.

We have a unique proprietary position in the RNAi space and I am confident that this will be further strengthened in the coming months and will be the basis upon which investors and pharmaceutical partners alike will take an increasing interest in this Company.

Through current licensing agreements, products based upon the Company's AtuRNAi technology are in the clinic and we plan to submit a regulatory filing before the end of 2008 to commence clinical trials for our lead internal development compound Atu027. I intend to commence partnering discussions, following the interest that has been expressed by a number of third parties in this development program."

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