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Orexigen(R) Therapeutics Presents Additional NB-302 Contrave(R) Data at American Diabetes Association (ADA) 69th Scientific Sessions
Date:6/6/2009

, which we believe meet the FDA efficacy guidance at the more stringent 10% threshold, also provide further support of Contrave's potential as a weight loss treatment for clinicians and their obese patients."

The overall discontinuation rate due to adverse events in NB-302 was 25.9% for patients taking Contrave versus 13.0% for those taking placebo. The most frequently observed adverse events leading to discontinuation for patients on study drug were nausea, urticaria (hives) and anxiety.

Contrave was generally well tolerated, with an overall safety profile consistent with its individual components, naltrexone and bupropion, two drugs that have been used separately for over 20 years. The discontinuation rate due to nausea was 4.6%. This rate is lower than what was seen in the Phase 2 trial (NB-201), which utilized the immediate release formulation of naltrexone as opposed to the proprietary SR formulation used in this trial. The most frequently observed treatment-emergent adverse events for patients on study drug were nausea, headache, constipation and dizziness.

About Contrave(R)

Contrave is an investigational oral weight loss medication with a unique mechanism of action that works at two levels within the central nervous system: one associated with controlling the balance of food intake and metabolism and another involved in controlling food preference, reward and cravings. We believe that Contrave may be the first treatment for obesity to target these reward centers in the central nervous system. Based on clinical trials completed to date, Contrave is believed to initiate and sustain significant weight loss over one year of treatment by reducing appetite, increasing metabolism and allowing the body to continue losing weight by offsetting its natural tendency to fight back and slow down the weight loss process.

About Orexigen(R) Therapeutics

Orexige
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SOURCE Orexigen Therapeutics, Inc.
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