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Orexigen(R) Therapeutics Issued a Key Fourth U.S. Patent on Contrave(R)
Date:1/5/2009

sing metabolism and allowing the body to continue losing weight by offsetting its natural tendency to fight back and slow down the weight loss process. Contrave is being studied in four Phase 3 trials, all of which have completed enrollment. We expect to provide results from all four Phase 3 trials by mid-2009. We remain on target to file a New Drug Application (NDA) with the FDA in late 2009.

About Orexigen(R) Therapeutics

Orexigen Therapeutics, Inc. is a biopharmaceutical company focused on the treatment of obesity. The Company's lead combination product candidates targeted for obesity are Contrave, which is in Phase 3 clinical trials, and Empatic(TM), which is in the later stages of Phase 2 clinical development. Each product candidate is designed to act on a specific group of neurons in the central nervous system with the goal of achieving appetite suppression and sustained weight loss. Further information about the company can be found at http://www.Orexigen.com.

Forward-Looking Statements

Orexigen cautions you that statements included in this press release that are not a description of historical facts are forward-looking statements. Words such as "believes," "anticipates," "plans," "expects," "indicates," "will," "intends," "potential," "suggests," "assuming," "designed," "projects" and similar expressions are intended to identify forward-looking statements. These statements are based on the Company's current beliefs and expectations. These forward-looking statements include statements regarding enrollment, timing, execution and completion of clinical trials of Contrave, the timing of an NDA submission with the FDA for Contrave, the efficacy and safety of Contrave, the potential to obtain regulatory approval for, and effectively treat obesity with, Contrave, and the potential issuance of patents and the scope and duration of p
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SOURCE Orexigen Therapeutics, Inc.
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