Navigation Links
Orexigen(R) Therapeutics Announces First of Four Phase 3 Trials of Contrave(R) Meets Co-Primary and Key Secondary Endpoints
Date:1/8/2009

Completers Contrave Placebo p-value** Contrave Placebo p-value** Weight Loss (%) 9.3% 5.1% <0.001 11.5% 7.3% <0.001 Weight Loss (lbs) 20.3 lbs 11.0 lbs <0.001 25.0 lbs 16.0 lbs <0.001 greater than or equal to 5% weight loss 66.4% 42.5% <0.001 80.4% 60.4% <0.001 greater than or equal to 10% weight loss 41.5% 20.2% <0.001 55.2% 30.2% <0.001 greater than or equal to 15% weight loss 29.1% 10.9% <0.001 39.5% 17.9% <0.001 * ITT, last observation carried forward (LOCF) analysis included all randomized subjects with baseline and at least one post-baseline measurement while on study drug. ** p-value based on difference between Contrave and placebo.

In order to assess how early study drug discontinuations affect efficacy measures, a post-hoc sensitivity analysis was conducted. In this analysis, we included all randomized patients who received at least one dose of study drug and had at least one post-baseline measurement of body weight. Contrave patients lost an average of 17.6 pounds, or 8.1% of their baseline body weight, versus 10.6 pounds, or 4.9% of baseline body weight for placebo patients. This analysis also showed that 56.8% of Contrave patients lost at least 5% of their body weight compared to 42.9% for placebo patients. All of these results remained highly statistically significant.

Secondary endpoints that demonstrated clinically and statistically significant improvements over placebo included HDL, triglycerides, waist circumference and hsCRP, markers of cardiovascular risk. Contrave patients also demonstrated improvements in quality of life compared to placebo patients as measured by the Impact of Weight on Quality of Life-Lite (IWQOL-Lite) scale, and decreases in sel
'/>"/>

SOURCE Orexigen Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. Orexigen(R) Therapeutics Issued a Key Fourth U.S. Patent on Contrave(R)
2. Orexigen(R) Therapeutics Announces Third Quarter 2008 Financial Results
3. Orexigen(R) Therapeutics Initiates First Clinical Trial of OREX-003 for the Mitigation of Antipsychotic-Associated Weight Gain
4. Orexigen(R) Therapeutics Appoints Dennis Kim, M.D., as Senior Vice President, Head of Obesity and Metabolic Disorders
5. Orexigen(R) Therapeutics to Present at Upcoming Investor Conferences
6. Orexigen(R) Therapeutics Schedules Webcast Discussion of Financial Results for the Second Quarter Ended June 30, 2008
7. OREXIGEN(R) Therapeutics Receives Notice of Allowance for U.S. Patent Covering the Composition of Matter in OREX-003
8. InteKrin Therapeutics to Present at the 27th Annual JP Morgan Healthcare Conference on Tuesday, January 13
9. Aegera Therapeutics Initiates A Randomized Phase 2 Combination Study of AEG35156 for 1st Line Treatment of Non-Small Cell Lung Cancer
10. Amicus Therapeutics Adds Sol J. Barer, Ph.D. to Board of Directors
11. Cell Therapeutics Announces Receipt of NASDAQ Panel Decision to Transfer to NASDAQ Capital Market
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... R-Biopharm is proud to ... hydrolyzed gluten in foods, has been accepted by AOAC International as Official First ... in Fermented Cereal-Based Products by R5 Competitive ELISA,” based on a specific monoclonal ...
(Date:7/30/2015)... ... , ... The 2015 Market Research Report on the Global Propanol Industry ... Propanol market with a focus on the Chinese situation. Major companies included in the ... Chemical, Sanofi, Royal Dutch Shell, LG Chem and Zhejiang Xinhua Chemical. , The report ...
(Date:7/30/2015)... across the globe, ISN improves the efficiency and effectiveness of contractor management systems. ISN,s ... reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 Countries ... Headquartered in Dallas, TX , ISN has additional offices in Calgary ...
(Date:7/30/2015)... ... July 30, 2015 , ... GEA's ... designed for continuous operation up to 1500 bar. The sanitary design gauge of ... preventing toxic contamination. , The Pony™ NS2006L homogenizer is an ideal solution for ...
Breaking Biology Technology:RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2
... Study Published in the Journal of Clinical Oncology Proves Accurate, ... ... Reaction (RT-PCR), REDWOOD CITY, Calif., June 2 Genomic ... of Clinical Oncology,(JCO) published results of a study confirming RT-PCR ...
... AKIVA, Israel, June 2 ITGI Medical, Ltd.,(TASE: ITGI) ... certified,Over and Under(R) Pericardium Covered Stent (PCS) in the ... covered with a heterologous tissue,designed to set a barrier ... is intended for situations such as degenerated Saphenous Vein,Graft ...
... Perceptive Informatics, the,technology subsidiary of PAREXEL International ... it has integrated its leading medical imaging,technology ... image,management and reporting system provided by Digisonics, ... assessment in clinical studies.,The system provides high-performance ...
Cached Biology Technology:Genomic Health Announces Expansion of Oncotype DX(R) Breast Cancer Test to Include Quantitative Estrogen Receptor (ER) and Progesterone Receptor (PR) Scores 2Genomic Health Announces Expansion of Oncotype DX(R) Breast Cancer Test to Include Quantitative Estrogen Receptor (ER) and Progesterone Receptor (PR) Scores 3Genomic Health Announces Expansion of Oncotype DX(R) Breast Cancer Test to Include Quantitative Estrogen Receptor (ER) and Progesterone Receptor (PR) Scores 4Over and Under(R) Pericardium Covered Stent is now in use in England and Proves Great Deliverability 2Perceptive Informatics Enhances Medical Imaging Capabilities for Assessment of Cardiac Function 2Perceptive Informatics Enhances Medical Imaging Capabilities for Assessment of Cardiac Function 3Perceptive Informatics Enhances Medical Imaging Capabilities for Assessment of Cardiac Function 4
(Date:7/31/2015)... de 2015 La 10 th International Conference ... de BGI del 22 al 25 de octubre de 2015 en ... año, la conferencia celebra su décimo aniversario. Desde su inauguración ... de las reuniones anuales más influyentes del mundo en el ... dinámicas, entusiastas y mejores a nivel científico. ...
(Date:7/30/2015)... 2015 Cellecta, Inc., a U.S.-based provider ... and biomarker discovery, announced the release of its ... all human protein coding genes. CRISPR technology enables ... gene,s function. Cellecta,s new Human Whole Genome CRISPR ... so that researchers can investigate in a single ...
(Date:7/23/2015)... Research and Markets ( http://www.researchandmarkets.com/research/rzzp3v/global_outlook_of ) ... Outlook of the Biometrics Industry 2015 " ... global biometrics market is likely to witness significant ... to the uptake of multiple technologies available. The ... the growth of biometrics in existing applications as ...
Breaking Biology News(10 mins):La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3
... streams and rivers, affecting the number and variety of some ... found. , Rivers and streams are key ecosystems for ... yet little emphasis has been given so far to the ... , Now a twenty-five year study at Llyn Brianne ...
... must prevent the immune system from launching an all-out ... a nutrient "floodgate" that serves to protect against such ... May 4, 2007 issue of the journal Cell, a ... animals lacking a protein enriched in fat cells, called ...
... University of Manchester researchers are ridding diabetic patients of ... with maggots. , Professor Andrew Boulton and his team ... patients whose foot ulcers were contaminated with MRSA and ... period of three weeks, much quicker than the 28-week ...
Cached Biology News:Keeping the immune system from starting a 'food fight' 2Maggots rid patients of MRSA 2
... Assay is an anchorage-independent growth assay in ... stringent assay for detecting malignant transformation of ... with carcinogens or carcinogen inhibitors) are cultured ... for 21-28 days. Following this incubation ...
The Saturn 2200 answers your GC/MS questions with the CP-3800 GC and the 2000 Series Ion Trap MS! These components create a platform for the worlds most versatile GC and flexible MS. Both deliver une...
... Kit uses a simplified procedure and streamlines ... The kit is based on the three ... and sodium bisulfite where cytosine is converted ... innovative in-column desulphonation reaction eliminates several precipitation ...
... Invitrogen makes blotting of E-PAGE Gels easier ... fiber blotting pad and several types of ... fit 8.6 cm x 13.5 cm E-PAGE ... membranes are designed for western transfer of ...
Biology Products: