Navigation Links
Oral PBI-1402 Demonstrates Significant Activity in Chemotherapy-Induced Anemia Phase II Clinical Trial
Date:4/23/2008

More than 90% of CIA patients treated with PBI-1402 did not require blood

transfusion.

MONTREAL, April 23 /PRNewswire-FirstCall/ - ProMetic Life Sciences Inc. (TSX: PLI) ("ProMetic") announces that oral PBI-1402 demonstrates significant activity in patients with chemotherapy-induced anemia ("CIA"), and reduces the need for red blood cell ("RBC") transfusion.

Only 2 patients out of 28 (7%) treated with PBI-1402 required a RBC transfusion, a response rate greater than 90% with regards to this clinical objective. In the March 13, 2008 FDA briefing document, the Oncologic Drugs Advisory Committee emphasizes that the primary objective of treating CIA patients with erythropoiesis-stimulating agents ("ESAs") as being the ability to reduce the need for RBC transfusion. The Advisory Committee cites that approximately 50% of anemic patients receiving chemotherapy required RBC transfusion, and 20%-25% of patients treated with ESAs still required RBC transfusions.

"These results are very exciting and meet the primary objective that formed the basis for FDA approval of other ESAs in CIA patients," states Mr. Pierre Laurin, President and Chief Executive Officer of ProMetic Life Sciences Inc. "This new encouraging data further supports the potential role PBI-1402 could play in the management of anemia in patients with cancer," added Mr. Laurin.

CIA patients enrolled in the study received a once daily oral dose of PBI-1402 during a period of eight weeks while undergoing their normal course of chemotherapy. All patients enrolled have completed the PBI-1402 treatment period.

About PBI-1402

PBI-1402 is an orally active compound being developed to treat different types of anemia, such as CIA. PBI-1402 has a distinct mechanism of action and does not act through EPO receptor. ProMetic has recently expanded its clinical program for PBI-1402 into the treatment of anemia in patients with myelodysplastic syndrome
'/>"/>

SOURCE PROMETIC LIFE SCIENCES INC.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. ProMetic reports continued positive data in PBI-1402 phase II trial in chemotherapy-induced anemia
2. ANX-530 Demonstrates Equivalent Pharmacokinetics to Navelbine(R) in a Registrational Bioequivalence Clinical Study
3. Bringing a New Rhythm to Cardiology Workflow: Siemens Demonstrates Answers to Cardiologys Toughest Questions
4. 960-Patient Study Demonstrates Zero Blood Stream Infection In Patients Treated With Angiotechs Novel 5-FU Central Venous Catheter
5. USGI Medical Demonstrates First System for Gastrotomy Closure in NOTES
6. Job-related stress: NIST demonstrates fatigue effects in silicon
7. Brostallicin Trial Data Demonstrates Encouraging Anti-tumor Activity in Patients With Chemotherapy-Resistant Cancers
8. Magnifi Group Demonstrates Industrys First Interactive Educational Program (IEP) for Spine Fellows
9. ARRIVE Registry Analysis Demonstrates Continued Safety and Efficacy of TAXUS(R) Stent in Complex Real-World Patients
10. Organons Asenapine Further Demonstrates Efficacy in Reducing Mania Symptoms for the Treatment of Bipolar I Disorder
11. Recent Study Confirms Alimentary Healths Bifantis(R) Demonstrates Efficacy in the Treatment of Irritable Bowel Syndrome

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2009)..., CALGARY and BLENHEIM, Ontario, Nov. 24 /PRNews...ed today it is acquiring the assets of Hyland Seed...tario. The addition of Hyland Seeds will further e...the company anticipates the introduction of Smart...de Tolerant Trait Technology in corn in 2012. The ...
(Date:11/24/2009)... , REYKJAVIK, Iceland, November ... (Nasdaq: DCGN ) today announced the approval of a...cy Court for the District of Delaware,(the "Bankru...etition for,relief under Chapter 11 of the United ..., The orders issued by the Bankruptcy Cou...
(Date:11/24/2009)...SEATTLE,Nov.24/PRNewswire/--BlueMarbleEnergyCorp.a...opmentAuthority(OPDA)wererecentlyawarded$2millionb...oard(CERB)inaprivate/publicpartnershiptoconstructt...colnCounty,WA. ,, "Thisinvestmentwillsignifican...70greenjobstoLincolnCounty,"saidBlueMarbleEnergyCE...
(Date:11/24/2009)..., DUBLIN, November 24 /PRNewswire-FirstCall...obal specialty biopharmaceutical company, today,an...n Medicines Agency for,velaglucerase alfa, the com...or the treatment of Type 1 Gaucher disease. This i...e alfa that has been submitted, with previous,subm...
Breaking Biology Technology:Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 2Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 3deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 2deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 3Blue Marble Energy, OPDA Awarded $2M by WA's Community Economic Revitalization Board 2Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 2Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 3Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 4
...edic Imaging, PARIS and ATLANTA, Oct. 9 Biospace...arance from the Food and Drug Administration,(FDA)...nited States for 2D,imaging use. EOS 2D|3D techno...ging,allowing images to be obtained with a low dos...al imaging, permitting full-body, uninterrupted di...
...echnology company translating the complexity of hu..., today announced that Andrea Matthews,(age 25), m... Mass High,Tech for its "People to Watch Under 30....idual like Andrea as,part of our team," said Dr. K..."She has been a go-getter ever since she started a...
...ey, OAK BROOK, Ill. and CARY, N.C., Oct. 9 The U...ce of academic medical centers and,their affiliate...ent,technology and services for academic and resea...rship to provide organizations participating in,UH...a robust, easy-to-use,procurement engine to stream...
Other Biology Technology:FDA Clears Biospace med's Revolutionary Low Dose Xray Imager 2FDA Clears Biospace med's Revolutionary Low Dose Xray Imager 3FDA Clears Biospace med's Revolutionary Low Dose Xray Imager 4Genstruct's Andrea Matthews Selected for Mass High Tech's 'People to Watch Under 30' 2University HealthSystem Consortium Chooses SciQuest to Optimize Medical Research Procurement 2University HealthSystem Consortium Chooses SciQuest to Optimize Medical Research Procurement 3
(Date:11/25/2009)...heart pumps some 250 million liters of blood throu...ibers of the heart have to be extremely durable. T..., vice chair of the Department of Medicine III at .... H. A. Katus), has discovered a protein that is r...lar unit, the sarcomere. In cooperation with other...
(Date:11/24/2009)...prescribed by traditional healers in Brazil to tre...pain to fever and flu. , Now for the first time, ... to scientifically prove the pain relieving proper...lian mint. , Testing this ancient South American ...Rocha was able to show that when prepared as a ,te...
(Date:11/24/2009)...ein that may help gut bacteria bind to the gastroi...iotic producers to identify strains that are likel...need to interact with cells lining the gut to have...es in the gut they are more likely to stick around...halie Juge from the Institute of Food Research. I...
Breaking Biology News(10 mins):New genetic cause of cardiac failure discovered 2Got a pain? -- Have a cup of Brazilian mint 2A sticky solution for identifying effective probiotics 2Data Published in The New England Journal of Medicine Support Use of Raxibacumab 28ABthrax 28TM 29 29 for the Treatment of Inhalation Anthrax 12949 1Data Published in The New England Journal of Medicine Support Use of Raxibacumab 28ABthrax 28TM 29 29 for the Treatment of Inhalation Anthrax 12949 2Data Published in The New England Journal of Medicine Support Use of Raxibacumab 28ABthrax 28TM 29 29 for the Treatment of Inhalation Anthrax 12949 3Data Published in The New England Journal of Medicine Support Use of Raxibacumab 28ABthrax 28TM 29 29 for the Treatment of Inhalation Anthrax 12949 4Data Published in The New England Journal of Medicine Support Use of Raxibacumab 28ABthrax 28TM 29 29 for the Treatment of Inhalation Anthrax 12949 5Go Healthy Announces Negotiations With Bottling Facilities 51183 1Go Healthy Announces Negotiations With Bottling Facilities 51183 2Cepheid Schedules 2009 Second Quarter Financial Results Announcement and Webcast 12948 1Cepheid Schedules 2009 Second Quarter Financial Results Announcement and Webcast 12948 2
...ditions to come , Human-induced climate change i...titudes. To assess whether the onset of drier con...wly developed multicentury tree ring records from ...on drought in northwestern Africa. Using a new set...ntica) and Aleppo pines ( Pinus halepensis ), the ...
...ellow. Do you gun the engine and speed through the...their green, or do you slow down and wait your tur...lity, according to new research from Tel Aviv Univ...he Department of Zoology at Tel Aviv University, r...le adopt risk-taking behaviors similar to those of...
...stigating exactly how chemotherapy drugs kill canc...test the effectiveness of safer new agents. , Dr S...y of Manchester,s Faculty of Life Sciences have ta...otic drugs, which are used extensively for breast ...s, which includes the agent taxol, has been used c...
Other Biology News:AGU journal highlights -- August 6, 2008 2AGU journal highlights -- August 6, 2008 3AGU journal highlights -- August 6, 2008 4AGU journal highlights -- August 6, 2008 5AGU journal highlights -- August 6, 2008 6AGU journal highlights -- August 6, 2008 7Humans' response to risk can be unnecessarily dangerous, finds Tel Aviv University study 2How chemo kills tumors: research to reduce side effects 2How chemo kills tumors: research to reduce side effects 3
10% BSA in TBS from Upstate
Rabbit Anti-Aortic Elastin Polyclonal Antibody, Unconjugated from Abcam
Anti-Mouse VEGF-C Antibody, Unconjugated from Raybiotech, Inc.
Rabbit Anti-MEF2A, phospho (Thr312) Antibody, Unconjugated from Spring Bioscience
Biology Products: