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Optimization and Scale-up of a Hydrodynamically Limited Anti-Solvent Crystallization Process: From Lab to Plant
Date:8/13/2009

This two part Optimization and Scale-up of a Hydrodynamically Limited Anti-Solvent Crystallization Process: From Lab to Plant webinar series is based on an award winning paper presented at the 16th International Process Development Conference. The webinar series focuses on a semi-quantitative method for the optimization and scale-up of hydrodynamically limited antisolvent crystallization process. This protocol combines in situ Process Analytical Technologies (PAT) with Computational Fluid Dynamics (CFD) to facilitate the production of a knowledge based scale-up strategy for this mixing limited crystallization process.

Columbia, MD (PRWEB) August 13, 2009 -- Part 1 of the Optimization and Scale-up of a Hydrodynamically Limited Anti-Solvent Crystallization Process webinar series takes place on September 24 and presents this optimization protocol. Certain attributes of turbulent mixing have been identified to greatly impact key crystallization characteristics, such as the metastable zone width (MSZW), primary and secondary nucleation events, growth and agglomeration rates. This section focuses on the use of Process Analytical Technology (PAT) and Computational Fluid Dynamics (CFD) in understanding these common industrial crystallization challenges and in turn facilitates the production of methods for the scale-up and scale-down of this process.

Part 2 of the Optimization and Scale-up of a Hydrodynamically Limited Anti-Solvent Crystallization Process webinar series, on October 1, takes the developed protocol to a scale-down and scale-up environment and demonstrates how

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