Navigation Links
Optical microscope without lenses produces high-resolution 3-D images on a chip
Date:5/3/2011

ng for years.

Ozcan, a researcher at the California NanoSystems Institute at UCLA, makes the analogy that a traditional optical microscope is like a huge set of pipes delivering content, in the form of images, to the user. Over years of development, bottlenecks occur that impede further improvement. Even if one part of the system that is, one bottleneck is improved, other bottlenecks keep that improvement from being fully realized. Not so with the lens-free system, according to Ozcan.

"Lens-free imaging removes the pipes altogether by utilizing an entirely new design," he said.

The system takes advantage of the fact that organic structures, such as cells, are partially transparent. So by shining a light on a sample of cells, the shadows created reveal not only the cells' outlines but details about their sub-cellular structures as well.

"These details can be captured and analyzed if the shadow is directed onto a digital sensor array," Isikman said. "The end result of this process is an image taken without using a lens."

Ozcan envisions this lens-free imaging system as one component in a lab-on-a-chip platform. It could potentially fit beneath a microfluidic chip, a tool for the precise control and manipulation of sub-millimeter biological samples and fluids, and the two tools would operate in tandem, with the microfluidic chip depositing and subsequently removing a sample from the lens-free imager in an automated, or high-throughput, process.

The platform's 3-D images are created by rotating the light source to illuminate the samples from multiple angles. These multiple angles also allow the system to utilize tomography, a powerful imaging technique. Through the use of tomography, the system is able to produce 3-D images without sacrificing resolution.

"The field of view of lens-based microscopes is limited because the lens focuses on a narrow area of a sample," Bishara said. "A lens-fre
'/>"/>

Contact: Mike Rodewald
mrodewald@cnsi.ucla.edu
310-267-5883
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. University of Pennsylvania scientists move optical computing closer to reality
2. SpectraScience Awarded Patent for Its Optical Biopsy System and Methods for Tissue Diagnosis
3. Paperwork: Buckypapers clarify electrical, optical behavior of nanotubes
4. New research field promises radical advances in optical technologies
5. Nanoscale dimensioning is fast, cheap with new NIST optical technique
6. Finesse Demonstrates TruFluor(TM) pH, a Single-Use Optical pH Sensor and Transmitter
7. Shamir Optical Industry Ltd. Announces Availability of Its Annual Report on Form 20-F Through Its Website
8. New nanolaser key to future optical computers and technologies
9. Reportlinker Adds Worldwide Optical, Transmission TEM, and Scanning SEM Electron Microscope Market Shares, Strategies, and Forecasts, 2009 to 2015
10. Small optical force can budge nanoscale objects
11. An optical traffic cop for rapid communication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... DALLAS , July 10, 2014  Kainos Capital, ... consumer brands, today announced that it has acquired the ... stake in the business. Terms of the transaction were ... loss and meal replacement business that markets ready-to-drink shakes, ... North America and in the ...
(Date:7/10/2014)... April 15, 2014 -- According to the International ... nuclear security comes from terrorists acquiring sufficient quantities ... construct a crude nuclear explosive device. The IAEA ... trafficking have involved gram-level quantities, which can be ... According to a new study appearing this week ...
(Date:7/10/2014)... the basis of psychiatric disorders has been extremely challenging ... risk but are insufficient to cause disease. Now investigators ... Press journal Cell Stem Cell describe a ... risks interact with other risk factors or environmental exposures ... research pinpoints a genetic variant that may predispose individuals ...
(Date:7/10/2014)... shelled out for crude 3-D glasses, polarized glasses, ... These basic devices, used to trick the brain ... be rendered obsolete with the introduction of new ... , TAU doctoral students Yuval Yifat, Michal Eitan, ... based on nanoantennas that could be used for ...
Breaking Biology Technology:Kainos Capital Acquires Slim-Fast From Unilever 2Sensitive detection method may help impede illicit nuclear trafficking 2New strategy could uncover genes at the root of psychiatric illnesses 2Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3
... April 24 Sinobiopharma, Inc. (OTC Bulletin Board: SNBP) ("Sinobiopharma" or, ... financial results for the nine month period ended February 28, 2009.Financial ... Sales revenue increased to US $2,715,702 for the ... corresponding period ended February 29, 2008. , ...
... 24 Dr. Susan Weinschenk is Chief of ... global leader of user experience design services. Dr. Weinschenk recently ... : What makes them click? ... decision makers immediately took note. Accolades about her book and ...
... -Testimony To Legislature Calls For Rejection Of Legislation That ... 24 In testimony to the Legislature and a ... largest biotechnology association warned that a bill under consideration ... and onerous regulatory environment for biotechnology growth and development ...
Cached Biology Technology:Sinobiopharma Reports a 141% Increase in Revenues From Unaudited Financial Results for the 9 Month Period Ended February 28, 2009 2Dr. Susan Weinschenk, Chief of Technical Staff and Services, Speaks on Neuro Web Design at 'Persuasive Technologies 2009 Conference' and 'Voices That Matter Web Design Conference' 2Regional Biotech Association Warns Legislation Would Make VT Least Friendly State in Nation for Biotechnology and Life Sciences 2
(Date:7/10/2014)... Society (ACS) announced today that Courtney Aldrich, Ph.D., ... Infectious Diseases as editor-in-chief. With the first ... pioneering journal will meet a growing demand for ... research. , "Our vision is to develop a ... on the basic science that advances the field ...
(Date:7/10/2014)... satellite spotted smoke over the U.S. Mid-West from ... , At 1200 UTC (8 a.m. EDT) on ... the brownish-colored haze created by forest fires in ... into South Dakota. This image was created by ... Flight Center, Greenbelt, Md. , According to ...
(Date:7/10/2014)... National Cancer Research Centre (CNIO) Macromolecular Crystallography Group ... protein called BuD to DNA in order to ... the researcher who led the study, says the ... the instructions contained in the genome to treat ... study is published in the journal Acta ...
Breaking Biology News(10 mins):ACS Infectious Diseases: Unique chemistry journal names editor 2CNIO scientists develop technology to redirect proteins towards specific areas of the genome 2
... AMES, Iowa Venture capitalist Vinod Khosla told last ... why he believes fuel blends containing 85 percent ethanol ... who last year told The New York Times ... companies developing ethanol production technologies ticked off several ...
... greatly increases the risk of heart attack and stroke ... the heart and blood vessels, researchers at the Saint Louis ... could lead to new therapies to treat or prevent heart ... States as well as answer key questions about other ...
... a prestigious American science journal proves that mercury atmospheric ... as three years. Biologists from the University of Alberta ... and carrying out the experiment. The study concludes ... other industrial activities were to be cut immediately, the ...
Cached Biology News:Iowa State University conference examines developing bioeconomy 2Research explains link between cholesterol and heart disease 2
... SureLINK HRP Conjugation Kits are based ... conjugates that are consistent and reproducible. ... to conjugate your protein or antibody, ... storage buffer. Activated HRP is ...
A component of the Acridinium protein labeling kit....
... Acridinium NHS ester can ... and nucleic acids. The covalently ... produce chemiluminescence in the presence ... ester-labeled proteins can be used ...
... The MiniOpticon 2-color real-time PCR detection system ... 48-well microplate. An array of 48 LEDs independently ... a pair of filtered photodiodes detects emitted light ... built on a MJ Mini cycler, whose Peltier ...
Biology Products: