Onyx Pharmaceuticals Reports Second Quarter and Six-Month 2008 Financi...(going basis and internally for operat...)

internally for operating, budgeting and financial planning purposes. Our

management excludes the effects of employee stock-based compensation

because of varying available valuation methodologies, subjective

assumptions and the variety of award types; such exclusion facilitates

comparisons of our operating results to our peer companies. Our

management believes the non-GAAP information is useful for investors by

offering them the ability to better identify trends in our business and

better understand how management evaluates our business.

These non-GAAP measures have limitations, however, because they do not

include all items of income and expense that affect Onyx. The non-GAAP

financial measures we use are not prepared in accordance with, and should

not be considered in isolation of, or as an alternative to, measurements

required by GAAP.