Navigation Links
Onyx Pharmaceuticals Initiates Phase 1 Study of Oral Proteasome Inhibitor in Advanced Solid Tumors
Date:6/1/2010

EMERYVILLE, Calif., June 1 /PRNewswire-FirstCall/ -- Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) today announced the initiation of a Phase 1 study of ONX 0912, an oral proteasome inhibitor, in patients with advanced refractory or recurrent solid tumors.

"Based on insights gained from our ongoing carfilzomib development program and ONX 0912's favorable preclinical profile – anti-tumor activity, safety and biodistribution – we believe ONX 0912 may have the potential to expand the use of proteasome inhibitors in the treatment of cancer," said Ted W. Love, M.D., Executive Vice President and Head of Research and Development at Onyx Pharmaceuticals.  "As an orally-dosed agent, ONX 0912 is designed to provide prolonged proteasome inhibition and easy combinability with other orally available therapies."  

Trial Design

This multicenter, open-label, dose-escalation study is evaluating the safety and tolerability of ONX 0912 in up to 50 patients with advanced refractory or recurrent solid tumor malignancies for which standard curative measures do not exist or are no longer effective.  The trial will determine the maximum tolerated dose (MTD), dose limiting toxicities, and pharmacokinetics/pharmacodynamics of ONX 0912 when administered orally on days 1 through 5 of a 14-day cycle.  Cohorts of 3 to 6 patients will receive ONX 0912 at escalating doses, starting at 30 mg, until MTD is determined.  Treatment will be repeated in 14-day cycles. The trial will be conducted in the United States.

About Onyx's Proteasome Inhibitor Development Program


'/>"/>
SOURCE Onyx Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Oramed Pharmaceuticals Announces Publication of Research Article on its Oral Insulin Capsule ORMD-0801 in Diabetes, Obesity and Metabolism
2. Co-Founder Gavin MacBeath, Ph.D. Joins Merrimack Pharmaceuticals as a Senior Director and the Head of Translational Research
3. Biostar Pharmaceuticals, Inc. Begins Assembly of New Production Line
4. Sinovac to Present at 2010 UBS Global Specialty Pharmaceuticals Conference
5. Idenix Pharmaceuticals to Present at Two Upcoming Investor Conferences
6. Amylin Pharmaceuticals to Present at the 2010 Citi Investment Research Global Healthcare Conference
7. Oramed Pharmaceuticals Announces That Dr. Michael Berelowitz, Senior Vice President at Pfizer, Joins its Board of Directors
8. Merrimack Pharmaceuticals Initiates Enrollment in Phase 1/2 Combination Study of MM-111 and Herceptin in Patients with Advanced Her2 Positive Breast Cancer
9. Biostar Pharmaceuticals, Inc. Announces First Quarter 2010 Financial Results
10. Astellas Pharma Inc. to Acquire OSI Pharmaceuticals, Inc.
11. Renhuang Pharmaceuticals Exhibits All-Natural Products at the 63rd PHARMACHINA Fair
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... PETERSBURG, Russia , July 10, 2014 ... Russian Federation Dmitry Medvedev , presented ... biopharmaceutical company BIOCAD . The Company is developing ... scope of MabNext project BIOCAD develops a number of ... cancer and autoimmune diseases. The ceremony took place at ...
(Date:7/10/2014)... 2014   Ceres, Inc . (Nasdaq: ... today financial results for the three months ended May ... Ceres reported that the company and its ... growing season in Brazil, which concluded in June, despite ... evaluation areas for part of the growing season. Yields ...
(Date:7/10/2014)... the journal PNAS (Proceedings of the National Academy ... and sleep deprivation have a significant effect on our ... the best time of day to test for diseases ... medicines effectively. , Researchers from the University of Surrey ... links between sleep deprivation, body clock disruption and metabolism, ...
(Date:7/10/2014)... forever. Nanophysics makes sure of that. Mechanics researchers at Linkping ... Physical Review E . Knowledge that can be of ... be able to sit still forever, and walk around upside ... soon be able to buy smart new fasteners that hold ... is, sooner or later the grip is lost, no matter ...
Breaking Biology Technology:Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Time of day crucial to accurately test for diseases, new research finds 2Even geckos can lose their grip 2
... drug discovery and development company eMetagen Corp . ... Marquette University Golden Angels Network , the angel investors ... Golden Angels investment, along with two grants received last ... the National Institutes of Health and a $150,000 Technology ...
... in any foreign land now requires a quick custom check. ... true nationality? What's this nation doing on the global scene ... Do I really like this nation? , ,It's no secret ... savvy than they were a decade ago. They clearly support ...
... - Ann Stunden, director of the Division of ... received a 2005 award for information technology leadership from ... honored Stunden for "strong and ground-breaking leadership in the ... 37 years ago." , ,A co-founder and executive ...
Cached Biology Technology:eMetagen gets $535,000 from MU angel investors 2Why are brands culturally profiled? 2Why are brands culturally profiled? 3
(Date:7/11/2014)... Researchers from Salk Institute for Biological Studies, BGI, ... the safety and reliability of the existing targeted ... method, TALEN-HDAdV, which could significantly increased gene-correction efficiency ... study published online in Cell Stell Cell ... cell-based gene therapy. , The combination of stem ...
(Date:7/11/2014)... 11, 2014 The increased risk of kidney injury ... resuscitation fluids reflects the mass of HES molecules, according ... official journal of the International Anesthesia Research Society (IARS). ... harmful effect of HES on cultured human renal proximal ... Christian Wunder and colleagues of University Hospital Wrzburg, Austria. ...
(Date:7/11/2014)... , July 11, 2014 Research ... "International Biometrics Technology Market - Industry Analysis Size ... to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... and crimes has created a need for high level ... used for personnel authentication such as username and passwords, ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2
... When students using the Ask a Biologist Web site ask ... actually accessing the combined knowledge of more than 150 volunteer ... "That,s why Dr. Biology is so amazing," says Charles Kazilek, ... on the planet." Kazilek,s site, which attracts 3,000-4,000 visitors ...
... for the Advancement of Science has chosen Arizona State ... science education, to receive the Science Prize ... The prize, established to "encourage innovation and excellence in ... resources by students, teachers, and the public," recognizes the ...
... fish species in the ocean, but the majestic gliding ... astonishing feat of mathematics and energy conservation. In new ... Functional Ecology marine scientists reveal how these ... buoyancy and stay afloat. For most animals movement ...
Cached Biology News:Science selects 'Ask a Biologist' website to win SPORE award 2Science selects 'Ask a Biologist' website to win SPORE award 3Science selects 'Ask a Biologist' website to win SPORE award 4ASU’s Ask A Biologist website wins prestigious SPORE prize 2ASU’s Ask A Biologist website wins prestigious SPORE prize 3Whale sharks do the math to avoid that sinking feeling 2
... (bluish-purple), DNA (blue), proteins (red) and acid polysaccharides ... traces: Ca ≤ 10 mg/kg Cd ≤ 5 mg/kg ... ≤ 5 mg/kg Fe ≤ 5 mg/kg K ≤ ... mg/kg Na ≤ 50 mg/kg Ni ≤ 5 mg/kg ...
... performance on minimum space. Thanks to a ... and cooling rates have been achieved that, ... maximum capacity of 48 x 0.2ml tubes, ... much more expensive 96 well instruments. Alternatively, ...
... available in a ready-to-use format. This ... dewaxing paraffin-embedded tissue sections prior to ... other analytical methods. The conventional method ... the slides in a series of ...
EZ-DeWax is a one-step solution that simultanously removes paraffin from and rehydrates formalin-fixed, paraffin embedded tissue...
Biology Products: