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One-Year Data Show Golimumab Improved Signs and Symptoms In Patients with Psoriatic Arthritis In Phase 3 Study
Date:10/27/2008

14, patients receiving golimumab 50 mg and 100 mg achieved a mean change of 6.53 and 7.85 scores, respectively, in PCS compared with a mean change of 0.63 among patients receiving placebo (P < 0.001). At six months, these results improved to mean changes of 7.42 and 8.22 in the respective treatment groups, compared with a mean improvement of 0.67 in the placebo group (P < 0.001). Also at week 14, patients receiving golimumab 50 mg achieved a mean change of 2.79 in MCS, while patients receiving golimumab 100 mg achieved a mean change of 3.56, compared with a mean change of 0.40 in patients treated with placebo (P < 0.05). At six months, patients receiving golimumab 50 mg and 100 mg achieved a mean change of 3.37 and 4.29, respectively, compared with 0.60 in placebo-treated patients (P < 0.05).

Self-reported productivity was measured on a Visual Analog Scale (VAS), a tool used to assess the patients' daily productivity at work, school or home. Patients receiving golimumab 50 mg and 100 mg experienced improvements in self-reported productivity, both at 16 and 24 weeks, while patients receiving placebo reported no change in their productivity at 16 weeks and a decrease in productivity at 24 weeks. Additionally, caregivers of golimumab-treated patients experienced a reduction of time lost from work through week 24, compared with caregivers of patients treated with placebo.

Nail, Enthesitis and Dactylitis Response

In patients with nail involvement or enthesitis at baseline, both golimumab treatment groups experienced improvements in psoriatic nail changes and enthesitis, as measured by the Nail Psoriasis Severity Index (NAPSI) and the psoriatic arthritis-modified Maastricht Ankylosing Spondylitis Enthesitis Score (MASES), respectively. In patients with dactylitis at baseline, both golimumab dose groups also experienced improvements in dactylitis, though the changes were not statistically significant with the 50 mg dose. Enthesitis, an inflammation of
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SOURCE Centocor
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