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One-Year Data Show Golimumab Improved Signs and Symptoms In Patients with Psoriatic Arthritis In Phase 3 Study
Date:10/27/2008

uing in the golimumab 100 mg group achieved ACR 20 response. Improvements were also observed in ACR 50 and ACR 70 measures within the same timeframes. Thirty-two percent and 38 percent of patients receiving golimumab 50 mg and 100 mg, respectively, achieved ACR 50 at week 24 compared with 4 percent of patients receiving placebo (P < 0.001). Fifty-seven percent and 53 percent of patients continuing in the respective golimumab dosing groups achieved ACR 50 response through one year. ACR 70 was achieved by 19 percent and 21 percent of patients receiving golimumab 50 mg and 100 mg, respectively, at 24 weeks compared to 1 percent of patients receiving placebo (P < 0.001). These results were sustained through one year with 43 percent of patients receiving golimumab 50 mg and 31 percent of patients receiving golimumab 100 mg achieving ACR 70.

The majority of patients treated with golimumab every four weeks experienced improvements in disease activity as measured by good or moderate Disease Activity Score 28 (DAS 28) response. At week 24, 64 percent and 78 percent of patients receiving golimumab 50 mg and 100 mg, respectively, were DAS 28 responders, compared with 24 percent of patients receiving placebo (P < 0.001). At one year, 93 percent and 86 percent of patients continuing to receive golimumab 50 mg and 100 mg, respectively, were DAS 28 responders.

Golimumab-treated patients also experienced substantial and sustained improvements in psoriatic skin disease through one year. Patients with greater than 3 percent Body Surface Area (BSA) psoriasis skin involvement at baseline were evaluated for Psoriatic Area and Severity Index (PASI) responses. At week 24, 56 percent of patients treated with golimumab 50 mg and 66 percent of patients treated with golimumab 100 mg achieved at least 75 percent improvement in PASI (PASI 75), compared with 1.4 percent of patients receiving placebo (P < 0.001). At one year, 62 percent and 69 percent of patients continuing in the g
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SOURCE Centocor
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